Intranasal interferon-based drugs
In the post-Soviet space, immunomodulatory drugs with an antiviral effect have become widespread. Pharmacologists have developed nasal drops and sprays containing interferon. The active substance does not enter the bloodstream and has a local effect on viruses. Therefore, it is advisable to use such drugs for the prevention of colds, as well as in the first 2-3 days after infection. The drugs on the market differ from each other primarily in the concentration of the active substance.
Grippferon
The drug Grippferon with human recombinant interferon alpha-2b is available in the form of nasal drops, spray and nasal ointment. The concentration of the active substance is 10,000 IU/ml. According to the manufacturer's instructions, the drug has the following advantages:
- characterized by activity against various pneumotropic viruses;
- reduces the duration of the disease (by 30-50%);
- reduces the likelihood of complications (up to 3.2 times);
- helps relieve the main symptoms of ARVI;
- provides a guarantee of protection against flu and colds during prevention (up to 96%).
Pathogenic viruses do not develop resistance to Grippferon. The product can be used by pregnant women and children of all ages. Contraindication is individual intolerance to the active substance.
Viferon
The drug Viferon is available in the form of a gel and ointment intended for local and external use. When treating ARVI, it is necessary to lubricate the mucous membrane of the nasal passages with the product. Viferon has an immunomodulatory and antiviral effect, which is enhanced by the presence of alpha-tocopherol acetate in the composition. This is vitamin E - a powerful natural antioxidant.
The concentration of the active substance for the gel is 36,000 IU/g, and for the ointment – 40,000 IU/g. Viferon is allowed to be used during pregnancy and lactation. Contraindications include children under 1 year of age and individual intolerance.
Genferon Light
Nasal spray Genferon Light with a concentration of interferon alpha-2b 50,000 IU is a powerful immunomodulatory drug with antiviral activity. The spray additionally contains taurine, which has the following effects:
- normalizes metabolic processes;
- accelerates tissue repair;
- stimulates the immune response.
Taurine is considered a powerful antioxidant. By neutralizing the action of free radicals, it prevents the development of various pathological processes.
The drug can be used during pregnancy. Contraindication is hypersensitivity to the components included in the composition. Spray Genferon Light is not allowed for use by children under 14 years of age.
Ingaron
Ingaron is available in the form of a lyophilisate for preparing a solution, which is then used to irrigate the nasal passages. It is based on interferon gamma with a concentration of 100,000 IU. The drug demonstrates activity against various subtypes of influenza virus, including H5N1 and H1N1. These strains are commonly known as “bird flu” and “swine flu”, respectively. The solution is also recommended to be instilled into the nasal cavity to prevent ARVI during an epidemic or in contact with a patient.
Ingaron is contraindicated during pregnancy and in case of individual intolerance to the components. It is allowed to be used when the patient reaches 7 years of age.
Interferon
A solution of human leukocyte interferon (1000 IU) is available for sale, which is available in ampoules. It is intended for inhalation and intranasal use. It is also possible to purchase dry lyophilized powder for subsequent self-dilution. The drug prevents the virus from entering the cell and prevents its DNA replication. The action of interferon also consists of stimulating the activity of cells involved in the formation of the immune response.
Due to the list of contraindications and side effects, the medicine should only be used in consultation with a doctor. The solution is strictly forbidden to be used for intramuscular and intravenous administration.
Note: interferon inducers are used exclusively in the post-Soviet space. In other countries they are not registered as medications due to unproven clinical effectiveness.
Pharmacological effect
When combined with the mucous membrane of the nasal cavity, microcellulose forms a gel-like coating - a filter that protects the body from microparticles inhaled with the air (viruses, bacteria, allergens, pollutants).; Wild garlic extract contains phytoncides that have antibacterial, fungicidal and antiviral effects.; Medium the size of cellulose microparticles is 118 microns (from 5 to 500 microns), which allows them to penetrate only into the nasopharynx, without reaching the trachea, bronchi, bronchioles and alveoli.; Nazaval plus is approved for use in children from birth, in women during pregnancy and lactation breasts, since Nazaval plus acts locally, does not penetrate into the blood, does not have a systemic effect and does not contain preservatives.
Purpose
Nazaval® PLUS acts as a natural barrier on the nasal mucosa and is used to protect against the penetration of viruses and bacteria that enter the upper respiratory tract when air is inhaled. It is a preventative against ARVI (including influenza) and other colds.
Mechanism of action
The powder of cellulose and wild garlic extract from the dispenser enters the nasal mucosa and forms a transparent, gel-like, protective layer that does not interfere with breathing. The gel-like layer is an effective barrier against viruses and bacteria, protecting the body from colds and ARVI. Due to its antiseptic properties, wild garlic extract inhibits the growth and neutralizes bacteria and viruses that enter the nasal mucosa with inhaled air.
Nasal spray, dosed Nazaval® PLUS is a barrier agent and does not have a systemic or local effect.
Other nasal agents with immunomodulatory effects
In addition to interferon preparations, the pharmaceutical market offers various sprays and nasal drops that activate immune reactions. They are used in the complex treatment of colds and flu, as well as for the prevention of various infectious diseases. This category includes:
- IRS 19 : the nasal spray is based on lysates of harmful bacteria. When the drug is sprayed into the nasal cavity, a local immune response develops in the shortest possible time. Thus, IRS-19 prevents the division and fixation of infectious agents on the mucous membrane. The drug is prescribed to children over 3 months and adults in the absence of contraindications.
- Thymogen : a medicine with the same active ingredient is available in the form of a nasal spray and is an immunostimulating agent. It has a reparative, antioxidant and desensitizing effect, and also suppresses inflammatory reactions. The drug is prescribed to adults and children over 1 year of age.
- Derinnat : nasal spray with the active ingredient sodium deoxyribonucleate activates humoral and cellular immunity. The medicine demonstrates effectiveness against harmful viruses, fungi and bacteria. It also promotes rapid healing of damaged mucous membranes. The drug is prescribed to adults and children from the 1st day of life.
These medications are not recommended for use during pregnancy and breastfeeding.
Medicines
It is customary to talk about a runny nose as a syndrome that occurs and goes away on its own, regardless of the measures taken to get rid of it. However, nasal drops for influenza and ARVI are used not only to relieve nasal congestion, but also to cope with the disease by activating the immune system.
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Today on the market of modern pharmaceutical products there are the following nasal drops for the flu, which have a complex therapeutic effect.
- "Grippferon" is a unique drug created by Russian scientists working in the pharmaceutical industry. Through their efforts, ordinary interferon, an antiviral component, was turned into the active substance “interferon alpha-2b,” which is completely safe for all categories of people, even pregnant women and children.
After contact with the nasal mucosa, the medicine deprives all viruses that are present and enter the nasopharynx during breathing and lose the ability to reproduce. As a result, recovery occurs several times faster, and the number of medications the patient takes is reduced several times.
Considering the fact that Grippferon does not destroy viruses, but only affects their ability to reproduce, a person cannot develop resistance to the drug.
“Grippferon” not only treats a person who uses nasal drops for the flu, but also prevents infection of surrounding people, that is, it has a positive effect on the prevention of epidemics.
- “Nazoferon” is a drug that also destroys viruses, fungi and bacteria on the surface of the mucous membrane, preventing their reproduction. Thus, the drug acts using the same component as “Grippferon” - “interferon alfa-2b”, that is, it is its analogue. The cost of the drops is also the same.
Using Nazoferon is very simple: you should put a few drops into each nostril and lightly massage the wings of the nose with your fingers so that the drug is better absorbed into the mucous membrane.
Nazoferon is a unique drug that prevents the proliferation of fungi, viruses and bacteria on the surface of the mucosa
If a person is diagnosed with a simple cold or acute respiratory viral infection with a mild symptomatic picture, other medications may not be needed. But if the doctor prescribes additional medications, Nazoveron will combine perfectly with any pharmacological composition.
- Interferon is an antiviral drug known to everyone in Russia, America and Europe. It is used to treat influenza, colds and even hepatitis, suggested to be taken in tablet form. However, there are also nasal drops on sale that serve as an excellent therapy.
The active ingredient of Interferon is a complex of natural alpha interferons obtained from human leukocytes. Thus, using the drug, a person adds additional antibodies to the antibodies produced by his immune system. Thus, victory over any antigen occurs much faster. Using Interferon in the form of a spray or drops, you can reduce the number of side effects of the drug, because the components will specifically work in the cells of those tissues that suffer most from a cold - the nasopharynx, the respiratory system.
- “Ingaron” is a Russian-made drug, the composition of which was created on the basis of lymphocytes, that is, “Ingaron” is nothing more than an immune interferon with a low molecular weight.
Using Ingaron is quite simple: first, the nasal passages are thoroughly washed with plain or salted water, after which two drops are poured into each nostril. You should tilt your head back a little and massage your nose with your fingers so that the drops have time to be absorbed and not flow out of the nose.
The product is not recommended for use in autoimmune pathologies, diabetes mellitus and pregnancy.
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Thus, modern drops for colds and flu make it possible not only to cope with the problem of a stuffy nose, but also to cure the pathology, destroy its causative agents, and prevent the transmission of the virus to others.
The main task of modern nasal drops is to prevent the transmission of the virus to others and to destroy pathogens
“Nazaval PLUS” - invisible protective mask
"Nazaval PLUS" is intended for the prevention of ARVI with an increased risk of infection. This nasal spray is a barrier agent that is not absorbed into the bloodstream, so it can be used at any age. The drug is not contraindicated for pregnant and lactating women.
The basis of the spray is wild garlic extract - wild garlic. The plant is characterized by a complex chemical composition: it contains phytoncides, vitamin C and the glycoside alliin. This determines the effectiveness of the drug. "Nazaval PLUS" has antiviral, antibacterial and fungicidal effects. When it is sprayed in the nose, a protective gel is formed, which is a kind of filter where infectious agents settle.
NAZAVAL PLUS 500MG. 200 DOSES NASAL SPRAY
Cost in pharmacies: Biomedservice on the street. 70 let Oktyabrya, no. 14, t. 70-06-71, cell. 8-913-636-03-69 430 rub. Biomedservice on the street. Kuibysheva, 62, tel. 56-94-88, 56-94-85, 8-913-685-12-21 425 rub. Biomedservice on Mira Avenue, 22, tel. 60-71-89, 60-62-73, cell. 8 983-526-39-96 450 rub. Biomedservice on the street. Ivan Alekseeva, 6, tel. 243-109, cell. 8-913-632-69-45 420 rub. Biomedservice st. Dekabristov, 45., 533-573, 8-913-649-42-83, 420 rub. Instructions for use:
RU - Federal Law No. 2009/04743 dated 07/08/200. Ingredients: microdispersed cellulose powder, wild garlic extract Excipients: peppermint extract
Dosage: 500 mg (200 doses). A bottle made of polyethylene with a patented spray dispenser and a screw cap. 1 bottle along with instructions is placed in a cardboard pack.
Shelf life: 3 years.
UK, https://nasavalplus.ru
New and unique nasal powder spray
· Protects the body from colds and flu throughout the season.
· Acts as an “invisible mask” against viruses and bacteria entering the body with inhaled air
· A safe and convenient way to prevent ARVI in all groups of the population, including children, women during pregnancy and breastfeeding.
What is Nazaval PLUS?
2 active components:
1. micronized cellulose
When combined with the mucus of the nasal cavity, microcellulose forms a gel-like coating - a filter that protects the body from microparticles inhaled in the air (viruses, bacteria, allergens, pollutants).
Protective role of cellulose
o Inhibits the growth of bacteria and viruses in confined spaces of the nose
o Safe to use for up to a year
o Cellulose has the ability to create a non-specific, unfavorable environment for viruses in the nasopharyngeal area
o Significant reduction in the severity of symptoms and duration of acute respiratory viral infection compared to placebo.
2. wild garlic extract
(Allium ursinum, wild garlic, bear onion)
How does Nazaval PLUS work?
· A special spray dispenser sprays an exact dosage of powder into the nose.
· A gel-like layer forms on the nasal mucosa, which, without affecting breathing, acts as a natural barrier or filter against viruses and bacteria inhaled with air.
· Due to its healing properties, wild garlic extract inhibits the growth and neutralizes bacteria and viruses.
· By protecting the nasal mucosa, Nazaval PLUS acts as an “invisible mask” against viruses and bacteria, preventing the onset of colds (ARVI, flu)
Scheme of application of Nazaval PLUS
Emergency protection
(before contact with a sick person, in crowded places, before traveling on public transport)
· 1 injection into each nasal passage while inhaling Once
Seasonal protection
(for daily protection against colds and flu all day long)
· 1 injection into each nasal passage while inhaling 2-3 times a day
How to use Nazaval PLUS?
Step 1. Before use, if necessary, hygienically clean the nasal cavity or blow your nose. Step 2. Gently shake the bottle. When using for the first time, it is recommended to make 1 or 2 test injections into the air. Step 3. Pinch one nasal passage with your finger, inhale the powder into the opposite nasal passage, pressing the walls of the bottle. Repeat the same procedure on the other side.
Daily use of Nazaval PLUS for protective preventive purposes:
· reliably prevents the onset of airborne infections (ARVI)
· protects against re-infection (reinfection)
Application of Nazaval PLUS during the period of active infection:
shortens the duration of the disease
Reduces the severity of ARVI
Why Nazaval PLUS?
Unlike other means of preventing colds and flu, Nazaval PLUS acts as an “invisible mask”:
Creates a transparent protective layer on the nasal mucosa
· Prevents viruses and bacteria from entering the body by forming a natural barrier in the nasal cavity
· Prevents the development of the disease
IMPORTANT!
Nazaval PLUS is not absorbed into the blood, does not have a systemic effect, and does not affect the immune system.
Nazaval PLUS
Creates a double natural barrier: mechanical and biological
Provides antibacterial and antiviral protection
· Consists only of natural ingredients
· Approved for use in adults, children, women during pregnancy and lactation
· Safe for long-term use throughout the cold season
Other drugs from the group Drugs to reduce symptoms of colds, inflammation of the pharynx, nasal cavity, ear
Drops with bactericidal and antiseptic effect
When infected with the flu or cold, bacterial rhinitis often develops. In this case, the patient will be helped by nasal drops and rinsing solutions, which destroy the membranes of harmful microbes and prevent their reproduction. The most popular drugs in this group are:
- Isofra;
- Albucid;
- Sialor;
- Miramistin;
- Collargol.
Polydex spray with phenylephrine deserves special mention - a combination drug with a wide spectrum of action. Thanks to its multicomponent composition, it suppresses the activity of pathogenic bacteria, reduces inflammation and improves breathing. However, the spray should be used only as prescribed by a doctor, since it contains the glucocorticosteroid dexamethasone.
Vasoconstrictor drugs
When you have a runny nose, breathing through your nose is difficult. In the symptomatic treatment of rhinitis, vasoconstrictor drops are used, which bring rapid relief. On the pharmaceutical market in this category there are drugs with such active ingredients as:
- Xylometazoline (Galazolin, Xylene, Rinonorm, Dlynos);
- Oxymetazoline (Nazol, Fervex; Nazivin, Fazin);
- Naphazolin (Naphthyzin, Tizin, Faryal, Sanorin).
Vasoconstrictor drops are not suitable for long-term use, as they cause fragility of blood vessels and dry out the nasal mucosa.
Note: nasal drops called Pinosol with peppermint, pine and eucalyptus oils will ease breathing and relieve inflammation. Another herbal preparation, Sinuforte, contains cyclamen extract, due to which it has an anti-flow effect and dilutes nasal secretions.
Indications for use and pharmacological action
Protection of the nasal mucosa from pollutants inhaled with air, including aeroallergens.
Individual intolerance to the components of the drug.
In a dry place, at room temperature. (with the lid screwed on tightly).
Keep out of the reach of children.
3 years. Use within 3 months after opening the package.
Do not use after the expiration date stated on the package.
Many people come to the pharmacy and don’t know which drug to choose: “Nazaval Plus” or “Nazaval”. Instructions for use “Nazaval Plus” recommends a remedy for the prevention of influenza and colds. In addition to micronized cellulose, it also contains wild garlic extract, which has antiviral and antibacterial effects due to the high content of phytocytes.
“Nazaval Plus” can be used as seasonal protection during the autumn-winter period, which is characterized by the spread of colds and flu epidemics. “Nazaval” is recommended as an antiallergic agent, which is suitable for regular use during the spring-summer season, characterized by flowering grasses and the presence of a large number of allergens in the air.
Contraindications to the use of the product may be individual intolerance to the components of “Nazaval” or “Nazaval Plus”.
These components include wild garlic extract, which is present in the Nazaval Plus preparation.
is a non-allergenic plant, which is why mint extract was chosen as a fragrance. But there are rare cases of hypersensitivity to mint, so if you have any unusual reactions after using the drug “Nazaval”, you should stop using it.
The drug can be used during pregnancy and breastfeeding, as it is not absorbed systemically and, accordingly, cannot harm either the mother or the child. It also has no age restrictions for use and is recommended for eliminating allergies even in infants.
Before using a new drug, you should familiarize yourself with what Nazaval is. Instructions for use and reviews can contain a lot of useful information that will help you choose the right version of the product. Those who have already used the presented spray can indicate its effectiveness in specific cases.
Reviews about the use of Nazaval nasal sprays as an antiallergic agent are mostly positive. Its high safety is noted, which allows the product to be used by pregnant, nursing mothers and children of any age. Also positive is the absence of preservatives, which often cause allergic reactions.
Those who have used Nazaval Plus to protect the body during the spread of infectious diseases note that when used correctly, the drug performs its functions. But in order for the product to be effective, you must strictly follow the action plan when using it. If it is impossible for parents to control the child’s use of the product in kindergarten or school, you should talk to a teacher or educator who can monitor the child’s actions or help him in using “Nazaval”.
The described medication provides protection to the nasal mucosa from allergy triggers such as pollen, various types of dust, and chemical-related substances.
The active base component of the drug is cellulose. Once sprayed, the product tends to settle on the nasal mucosa and provides 24-hour care. Indications for purchasing Nazaval are relevant for people of any age without deterioration in memory function, tendency to sleep or suppression of appetite.
Nazaval helps allergy sufferers prevent the appearance of signs of allergic rhinitis:
- abundant mucous formations from the nasal sinuses;
- difficulties with natural breathing;
- swelling of the nasopharyngeal mucosa;
- manifestations of redness and itching in the nose;
- sneezing.
This medicinal development blocks the aggressive action of everything that surrounds us, which provoke allergies, and helps prevent the full development of the immune system reaction to alleviate the unpleasant manifestations that have begun.
Application and action of Nazaval Plus
Micronized cellulose is the main component of the drug; In addition, there is mint extract in addition. Today, another type of medicine is produced - Nazaval plus. Nazaval plus: instructions for use, discussed below, are very similar to the original. The only difference from the usual Nazaval is the additional use of wild garlic extract, which actively resists the initial manifestations of colds.
The described aerosol is contraindicated only in case of personal intolerance to the components. And there are practically no side effects, since this drug does not involve any influence in the system. Its safety is guaranteed due to the absence of contact with organs and tissues of the body. Nazaval spray affects the efficiency of driving and does not contribute to the appearance of a drowsy state.
Cromohexal nasal spray. Not just for allergies
According to experts and clients, Nazaval nasal spray with a cellulose powder base is absolutely natural. The plant origin and pleasant smell of mint gives easy tolerance and excellent results after taking it. The drug blocks the penetration of various types of viruses and bacteria into the nasal cavity, creating an invisible gel-like film. Garlic extract also gives this effect.
According to numerous reviews from doctors and patients, the described product has a number of advantages. It is hypoallergenic, does not contain preservatives, has a wide spectrum of action, has no side effects, is practically free of contraindications, does not “disturb” the body with systemic effects, does not provoke addiction and is affordable.
This product is purchased at pharmacies, including online options. The main thing is to inform your doctor and dosage correctly to avoid potential problems.
Protection of the nasal mucosa from the penetration of viruses, bacteria and aggressive environmental factors in children and adults, including women during pregnancy and lactation.
individual intolerance to the components of the drug;
allergic reactions to garlic;
tendency to nosebleeds.
3 years. Use within 6 months after opening the package.
Sinus rinses
Rinsing the nasal passages with an isotonic solution based on sea salt will help quickly get rid of a runny nose, which is a common complication of flu and colds. The saline solution helps moisturize the upper respiratory tract, remove mucus and reduce swelling. The following drugs are presented in this category:
- Quicks;
- Aqualor;
- Physiometer;
- Otrivin Sea;
- Marimer;
- Aqua Maris;
- Humer;
- Morenasal.
Seawater-based products are suitable for long-term use. It is imperative to rinse your nose before using other intranasal agents.
Homeopathic nasal drops
The effectiveness of using homeopathic medicines for colds and flu has not been confirmed by clinical studies. However, patients are attracted by the natural composition of the proposed products and their good tolerability. The use of alternative medicine methods is possible only in combination with traditional drug therapy. The following homeopathic remedies are used to combat a runny nose:
- Edas-117;
- Edas-131;
- Edas-801 Thuja oil;
- Euphorbium compositum;
- Aflubin spray.
Treatment of ARVI requires considerable labor, so prevention plays a paramount role. To protect yourself from infection, you need to follow a daily routine, eliminate bad habits, eat right and take vitamin complexes.
The best nasal drops for colds and flu
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