What to choose: Isofra or Nasonex?

Composition and properties of the drug

Helps well with nasopharyngitis, sinusitis, rhinitis

Isofra goes on sale in spray form. It is produced by the French company Laboratoires Bouchara.

The active substance of the drug is framycetin. It is contained in 1 ml of the drug in the amount of 12.5 mg.

In addition to the main substance, the antibiotic contains auxiliary components. These include:

1. Lemon acid.
2. Distilled water.
3. Sodium citrate.
4. Methylparaben.
5. Sodium chloride.

The active substance of the drug belongs to the group of aminoglycosides. They are effective against pathogenic bacteria that multiply in the nasopharynx during illness. The antibiotic is characterized by a destructive effect on the membrane of pathogens, as a result of which they die.

Avamis and Polydexa can be used simultaneously

Polydexa is an effective remedy for curing diseases from the category of otorhinolaryngology. Its effectiveness is due to the presence of active substances in the composition - antibiotics neomycin and polymyxin. It is used not only in the ENT office, but also at home. Many patients wonder what analogues of Polydex are available and how effective they are.

Nasal spray has a pronounced effect against harmful microorganisms and bacteria.

Such organisms become the root cause of the development of undesirable processes in the respiratory tract and nasal sinuses.

The drug quickly relieves acute signs of the disease and improves breathing within five days.

The therapeutic result is based on the substances included in the composition:

1. Dexamethasone. Characterized by an antiphlogistic effect.
2. Neomycin. An antibiotic that is effective against staphylococcus, E. coli, and Haemophilus influenzae.
3. Polymyxin. It is characterized by antibacterial effects against Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.

The main substances complement each other and expand the range of effects on a large number of gram-positive and gram-negative microflora.

Such floras become the root cause of the progression of inflammatory processes in the nasal cavity. The medication has a destructive effect on the membrane membrane of pathogenic organisms.

Streptococci and anaerobic flora are resistant to the product.

Polydexa and its analogues are prescribed for:

It is produced in the form of drops in the nose and ears, and a spray. Only the attending physician should prescribe the product.

The diseases that are indications for using the drug are very serious. If treated incorrectly, exacerbations are possible. Polydex drops with phenylephrine have a complex composition, so it is important to follow the indicated dose and frequency of administration.

Each drug has a number of analogues. Thanks to them it is possible to achieve a similar result. Below is a list of analogues of Polydex in the nose.

The list of analogues is long. Analogues are cheaper than the drug, but have an identical effect. These are:

1. Sofradex. Nasal drops act as an antibacterial medicine with a wide range of effects. They have antiphlogistic, antiallergic and bactericidal properties. Successfully copes with infections. The active substance relieves inflammation and prevents the proliferation of pathogens. A couple of days after use, the itching and burning disappear. Use with caution for children.
2. Fliconase. Has an anti-edematous effect. It also has an antiphlogistic and antiallergic effect. It is produced in the form of a spray and nasal drops. After use, the frequency of sneezing decreases and the itching in the nose goes away. Relieves nasal congestion. Relieves eye symptoms. The course of therapy is prescribed only by the attending doctor.
3. Tafen. This is a nasal aerosol that has antiphlogistic and antiallergic effects. Indicated for runny nose of any nature and for preventive purposes. The full effect is achieved after 2 days. The severity of symptoms decreases. Indicated for allergic and non-allergic rhinitis, nasal polyps.
4. Influrin. Indicated for rhinitis, otitis, sinusitis. Constricts blood vessels, which eliminates swelling. Breathing becomes much easier. Should not be used during pregnancy and breastfeeding. Usually 2-3 drops are instilled into each passage four times a day.
5. Rhinostop. The medicine is produced in the form of drops or spray. Indicated for acute otitis, sinusitis and rhinitis. Characterized by a vasoconstrictor effect. This eliminates swelling and makes nasal breathing easier. It is the cheapest Russian-made substitute.
6. Nasobek. A nasal spray that helps with chronic or allergic rhinitis. Reduces swelling of the mucous membrane of the olfactory organ. Can be used by children from 6 years old. Well tolerated with long-term therapy.
7. Isofra. A high-quality substitute and you can buy it cheaper. Acts as an antibiotic covering a wide spectrum of effects. Fights against gram-positive and gram-negative flora. Indicated for rhinitis, sinusitis, rhinopharyngitis.
8. Avamis. This is a nasal spray characterized by an antiphlogistic effect. It is actively used to treat rhinitis caused by allergies. Successfully relieves the symptoms of sinusitis and sinusitis. It not only eliminates swelling of the nose, but also improves the general condition of the patient.
9. Rhinorus. This is an inexpensive medicine substitute that is effective for rhinitis, otitis media and sinusitis. Has a vasoconstrictor effect. Quickly eliminates swelling and makes breathing easier. Restores the patency of the nasal passages.
10. Nosol. The best Ukrainian replacement medication, the action of which is aimed at moisturizing the nasal mucosa. Thanks to it, sputum and pus are dissolved. The process of their removal is greatly facilitated.
11. Eucazolin. Actively narrows capillaries. After use, breathing becomes easier. Thanks to the eucalyptus oil in the composition, the nasal mucosa is moisturized. Relieves nasal congestion.

Self-medication is prohibited, so the choice of medication remains with the doctor after examining the patient.

The presented list includes cheap substitutes for Ukrainian-made products:

1. Cipropharm Dex. An antimicrobial drug that is used to treat otitis media. Produced in the form of drops and suspension. Used to treat children from six months of age. Use the medicine with special care during pregnancy.
2. Nazo Spray Baby. This is a decongestant medicine that is intended to cure suppurative processes in the nasal area. Indicated not only for otitis media, but also for runny nose.
3. Anauran. This analogue of Polydexa has an antibacterial and anesthetic effect. The product copes with otitis media. The frequency of use and dosage are prescribed only by the doctor. It is not recommended to use them for more than a week.
4. Otofa. A cheap substitute characterized by an antibacterial effect. Active against various infections. Effective in chronic and acute otitis media. It is recommended to use no more than a week.

All of the above medications should be taken as part of a systemic treatment for the disease. When choosing substitutes, be sure to get the advice of a doctor. Incorrect and untimely use of medications can worsen the course of the disease. This leads to a number of exacerbations:

• layering of fungal infection;
• changes in the flora of the digestive tract;
• fetal abnormalities during pregnancy;
• complications that affect the cardiovascular system.

When treating a disease with Polydexa, side effects may occur. They appear in case of violation of the dosage and frequency of administration. During therapy, it is important to monitor your health. If negative reactions occur, you should stop taking it and consult your doctor.

From all that has been said, the conclusion is that replacement medications successfully cope with diseases of the paranasal sinuses, otitis media and rhinitis. The use of any means must be under the supervision of the attending physician. If you are allergic to the main components in the composition, the medication that is as similar in effect as possible is selected.

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It happens that a cold or allergic runny nose is complicated by a bacterial infection, develops into sinusitis or sinusitis, and curing it is not so easy. Some of the drugs that can help cope with such ENT diseases are Nasonex and Polydexa.

In severe forms of respiratory tract diseases, especially those complicated by an associated bacterial infection, antibiotics and drugs that relieve inflammation cannot be avoided. Therefore, ENT doctors quite often resort to local nasal sprays. The advantages of such medicines are:

1. A quick effect that develops almost immediately as the drug enters the nasal mucosa.
2. Almost complete absence of a general effect on the body, and therefore most of the side effects that drugs for oral administration, especially antibiotics, have.
3. Pronounced and rapid local action, which allows the use of such drugs even in the youngest patients, starting from two to three years of age.

Despite the similarity of treatment effects and indications for use, Polydex and Nasonex differ in composition and mechanism of action.

It is a combination drug that contains several medicinal substances:

• Neomycin is an antibiotic from the group of aminoglycosides, has a bactericidal effect, that is, it causes cell death, disrupting important synthesis processes in it, in particular protein synthesis.
• Phenylephrine is a substance that causes constriction of blood vessels, including small ones, facilitating breathing and relieving swelling.
• Polymyxin is another antibiotic, only from the group of polypeptides. It differs in that, by attaching to the membranes of bacterial cells, it causes their destruction, that is, it also belongs to bactericidal agents.
• Dexamethasone is a synthetic glucocorticosteroid, that is, a substance similar in its structure and effect on hormones that are normally produced in the human body, in particular by the adrenal cortex. Relieves itching, irritation and inflammation.

Thanks to this composition, Polydex for the nose has the ability to relieve inflammation, facilitate breathing and kill bacteria that cause an infectious disease.

Polydexa comes in two dosage forms: nasal spray and ear drops. Unlike the first drug, the drops do not contain phenylephrine and have a lower concentration of dexamethasone. You cannot replace one medicine with another.

Nasonex contains only one substance - mometasone fuorate. Like dexamethasone in Polydex, it is a synthetic glucocorticosteroid. It has pronounced anti-inflammatory and antiallergic effects and, when applied topically, has virtually no general effect.

The main mechanism for the development of the therapeutic effect is the inhibition of various inflammatory mediators - substances that are produced in the body in response to the penetration of bacteria, viruses or allergens and cause the development of the disease.

In addition, Nasonex helps special cells of the immune system - neutrophils - accumulate at the site of infection and thereby also blocks its spread.

Despite the fact that Nasonex is considered one of the safest glucocorticoid drugs, it is available by prescription and should only be used as prescribed by a doctor.

Can Polydexa and Nasonex be used simultaneously? Yes, for some diseases these medications are indeed prescribed together. However, they are used only in difficult situations when other means have not had the desired effect. So, your doctor may prescribe the following combination for you or your child:

1. For severe seasonal or year-round rhinitis, especially with associated bacterial infection.
2. For sinusitis, nasopharyngitis or sinusitis, both acute and chronic, but only in the presence of a bacterial infection.
3. In some cases with adenoids.

Source: https://str-control.ru/preparaty-dlya-lecheniya-nasmorka/avamis-i-polideksa-odnovremenno-mozhno/

Indications for use

With the help of Isofra, local treatment of adenoids is carried out. Its active substance acts directly on the mucous membrane of the rhinopharyngeal zone. Taking into account this feature and the effect of the drug, an antibiotic is prescribed if the patient has the following indications:

• Vasomotor rhinitis.
• Allergic lesion of the nose.
• Acute nasopharyngitis.
• Tonsillitis.
• Acute and chronic sinusitis.
• Pharyngitis.
• Adenoids.

Treatment with a spray may be indicated if a child has diseases of the nose or its appendages that are bacterial in nature.

Isofra can be used in the treatment of children of any age. Although there is a contraindication for its use in children under 1 year of age.

The doctor prescribes a drug with an antibacterial effect to the child only after determining the presence of indications for such therapy. In other cases, its use may be irrelevant and ineffective.

Contraindications

When prescribing sprays for therapeutic measures, one should take into account the possible presence of contraindications for use in the patient.

The main contraindications to the use of Nasonex are:

• individual intolerance to any of the components included in the drug;
• the patient has an untreated or undertreated local infection, provided that the nasal mucosa is involved in the pathological process;
• identified active or latent form of tuberculosis infection of the respiratory tract;
• untreated infection of a bacterial, viral or mycotic form, as well as an infectious process provoked by the herpes simplex virus that affects the eyes.

In case of recent injury to the nose or surgical intervention on the organ, the use of the drug is prohibited until the wounds have completely healed.

For Polydex there are the following contraindications for use:

1. The presence of high sensitivity to its components.
2. If there is a suspicion of angle-closure glaucoma.
3. In case of using MAO inhibitors.
4. When identifying kidney diseases in which albuminuria occurs.

Contraindications and side effects

The drug should not be given to children

The drug "Isofra", which is prescribed for adenoids in children, is well tolerated by patients. During clinical studies, no cases of side effects occurred in patients. Therefore, information about them is not contained in the instructions for the antibiotic.

The drug has a number of contraindications for which its use is unacceptable. We are talking about the following conditions:

• Individual intolerance to the components contained in the drug.
• Children's age up to 1 year.

It is also not recommended to use the medicine to rinse the sinuses. For such procedures, more suitable means should be chosen.

If the patient requires taking other medications along with Isofra, then this issue must be discussed with a specialist. He must check the compatibility of medications and ensure the safety of such therapy.

Scheme for using Isofra for adenoids

The antibiotic "Isofra" is prescribed to children for adenoids and other diseases of the ENT organs. To achieve a therapeutic effect, it is enough to make a single injection three times a day. This treatment regimen must be followed for 7-10 days.

If the child’s condition does not improve 3-4 days after starting the drug, it may need to be replaced. The option of additional inclusion of an agent that belongs to the group of systemic antibiotics is also being considered.

The spray does not cause any problems in application. Before starting the procedure, you need to pick up the bottle, shake it, and then make one injection into the nostril. At this time, it should be placed in an upright position.

It is necessary to start rinsing the nose after its cavities have been thoroughly cleaned. To do this, it is advisable to wash the organ. This is a mandatory procedure that will prepare the affected area for treatment. Otherwise, the therapy will not have a positive result, since the active substance of the drug will not reach the source of inflammation.

It is necessary to remember the following points regarding treatment with Isofra:

1. For a sick child with adenoids, it is enough to inject only 1 dose of the drug three times a day.
2. Adults need to inject the medicine in the amount of 1 dose about 4-6 times a day.
3. Spray-based therapy lasts no more than 10 days. It is undesirable to exceed the permissible duration of treatment, as this may lead to negative reactions.

Compliance with the basic requirements allows you to achieve high effectiveness of treatment with the Isofra antibiotic. The child’s attending physician should warn the child’s parents about this. If the drug is used in the wrong dosage, this can lead to low effectiveness of therapy.

III. What are the indisputable advantages of Isofra over other nasal competitors?

As already mentioned, “Isofra” is one of the few antibiotics that exhibit minimal penicillin-induced pathogenic complications, disorders in the digestive organs (diarrhea, diarrhea, bloating). This medicine, unlike Nasonex, Polydex, silver-containing pharmacological drugs, hormonal drugs (Rinofluimucil), is prescribed under the supervision of a doctor, to the youngest patients (from 3 months).

Related articles How to reduce adenoids in a child without surgery: acupuncture, treatment with honey melt water

Isofra is widely used as an effective preventive medication. The medication “recognizes” just beginning adenoid pathogenesis in the nasopharyngeal locations of children. Slowly but methodically destroys the membrane cellular (gene) level of viral, pathogenic, and malicious bacterial strains.

Otolaryngologists, with primary suspicions of adenoid invasion, prefer to prescribe Isofra rather than another nasal medicine as a proactive technique. Especially when it comes to infants, weakened children (after prolonged somatic illnesses) - influenza, sore throat, chronic acute respiratory viral infections, acute respiratory infections.

"Isofra" must be administered in the post-surgical period, as a preventive measure to prevent postoperative bacterial infections. Moreover, children easily tolerate the use of Isofra without negative symptoms.

The drug is available only in the form of a spray, in vacuum packaging (can), with a built-in cap-nozzle (spray). The medicinal mixture is supplied under moderate pressure with a fine dispersion consistency. “Isofra” is used to treat the nasal passages (before the initial rinsing of the nasal canals with salt water). The medicine has the best effect if it is not stored for a long time (you should not buy it for future use). The course of treatment lasts 7-10 days, so the drug should be purchased at the pharmacy after a doctor’s prescription and used immediately. It is not recommended to leave the remaining mixture unused (for another time). Framycetin quickly decomposes and loses its clinical properties.

Drug interactions

During the study of drug interactions between the drug with antibacterial action and other medications, no negative reactions were identified. Experts only warn that Isofra may adversely affect the effectiveness of local medications intended to treat fungal infections.

Simultaneous use of Isofra and Nasonex

The drugs "Isofra" and "Nasonex" can be used simultaneously, if necessary, at the discretion of the specialist.

The simultaneous use of drugs helps to enhance the antibacterial effect that they provide. A certain treatment regimen can achieve this result. Therapy begins with taking Isofra. In the middle of the course, Nasonex is included in it.

The auxiliary agent must be dripped once a day. This does not take into account the need to use other medications.

How to take Nasonex and Polydex?

Nasonex is a drug intended for intranasal use. Administration is carried out using a dosing nozzle, which is equipped with a bottle of medicine.

Before use, calibrate by 6-7 clicks on the dosing device. This allows you to establish a stereotypical delivery of the medication. Each press releases 100 mg of suspension into the nasal cavity, which contains 50 mcg of pure active ingredient.

Before handling, the bottle must be shaken vigorously several times.

The dosage of the medicine differs depending on the type of disease. For allergic rhinitis, the instructions for use recommend taking 2 inhalations into each nasal passage once a day. After achieving the required therapeutic effect, the dosage is reduced by half.

For exacerbations of sinusitis, 2 inhalations are administered into each nasal passage, 2 times a day. For sinusitis, the use of the drug is auxiliary and complements the main therapy.

If adenoids are detected, the use of the drug helps reduce swelling and prevent the need for surgery.

According to the doctor's prescription and instructions for use, children over 12 years of age are allowed to take no more than 3 injections of Polydex per day into each nasal passage. The duration of therapy is from 5 to 10 days. When injecting, the bottle must be kept in an upright position.

The product should not be used as a rinsing preparation for the paranasal sinuses. The therapeutic effect of Polydex depends largely on the individual characteristics of the body.

Polydexa and Nasonex should only be prescribed by your doctor.