Flemoklav solutab instructions for use, contraindications, side effects, reviews

• August 11, 2020
• Infectious
• Ulyana Romanova

“Flemoclav Solutab” (875 mg + 125 mg), instructions for use of which will be studied in this article, is a combined preparation of clavulanic acid and amoxicillin. For what diseases is it prescribed? What are the contraindications? And how to take this medication correctly? You will find out the answers to these and many other questions below.

Composition and price

"Flemoklav Solutab" is available in the form of oblong tablets, white or slightly yellowish in color. Each contains 1019.8 mg of amoxicillin trihydrate, which corresponds to “pure” amoxicillin in the amount of 875 mg.

Also present is 148.9 mg of potassium clavulanate. This in turn corresponds to 125 mg of clavulanic acid.

The composition also contains excipients - dispersed and microcrystalline cellulose, magnesium stearate, saccharin, crospovidone, flavorings and vanillin.

The average price of Flemoklav Solutab (pack of 14 tablets) is about 450 rubles.

Release form and composition

Flemoklav Solutab is produced in the form of dispersible tablets: oblong, without marks, from yellow to white with brown dotted spots, marked depending on the dose - “421” (125 mg/31.25 mg), “422” (250 mg/62 .5 mg), “424” (500 mg/125 mg); “425” (875 mg/125 mg) and the company’s graphic logo (125 mg/31.25 mg each: 4 pieces in blisters, 5 blisters in a cardboard box; 5 pieces in blisters, 4 blisters in a cardboard box pack; 250 mg/62.5 mg and 500 mg/125 mg: 4 pieces in blisters, 5 blisters in a cardboard box; 875 mg/125 mg, 7 pieces in blisters, 1 or 2 blisters in cardboard box).

1 tablet contains active substances (respectively):

• Amoxicillin – 125/250/500/875 mg (in the form of amoxicillin trihydrate – 145.7/291/528.8/1019.8 mg);
• Clavulanic acid – 31.25/62.5/125/125 mg (in the form of potassium clavulanate – 37.2/74.5/148.9/148.9 mg).

Auxiliary components: microcrystalline cellulose, saccharin, crospovidone, apricot flavor, vanillin, magnesium stearate.

Impact on the body

This combined medication is bactericidal, its mechanism of action is based on the synthesis of the bacterial wall.

The list of pathogenic microorganisms against which it is active includes dozens of items. However, this substance is not omnipotent and universal. Plus, amoxicillin is destroyed by beta-lactamases, which is why its spectrum of activity does not extend to bacteria that produce this enzyme.

But there is a nuance. The previously mentioned clavulanic acid is an inhibitor of these beta-lactamases. Its structure is similar to that of penicillins. And clavulanic acid inactivates most beta-lactamases found in microorganisms resistant to cephalosporins and penicillins.

However, there are many bacteria that Flemoklav Solutab (875 mg + 125 mg) does not affect. That is why antibiotic treatment is always prescribed by a doctor. First, you need to conduct an examination, study the patient’s medical history, as well as the tests he has taken to help identify the pathogen.

Directions for use and dosage

Flemoclav Solutab is taken orally by swallowing the tablets whole with a glass of water or dissolving and stirring them thoroughly before use in half a glass of water (minimum volume - 30 ml). To avoid the development of side effects from the digestive system, Flemoklav Solutab is recommended to be taken at the beginning of a meal.

A single dose for adults and children from 12 years of age and children under 12 years of age weighing more than 40 kg is 1 tablet 875 mg/125 mg, the frequency of administration is 2 times a day (with a 12-hour break).

Children under 12 years of age weighing less than 40 kg should take the drug in smaller dosages. As a rule, the daily dose per kg of body weight is 20-30 mg of amoxicillin and 5-7.5 mg of clavulanic acid:

• 3-24 months (weight – 5-12 kg): 2 times a day, 1 tablet 125 mg/31.25 mg;
• 2-7 years (weight – 13-25 kg): 3 times a day, 1 tablet 125 mg/31.25 mg;
• 7-12 years (weight – 25-37 kg): 3 times a day, 1 tablet 250 mg/62.5 mg.

Adults and children weighing more than 40 kg can take Flemoclav Solutab 3 times a day, 500 mg/125 mg. For chronic, severe and recurrent infections, it is possible to increase the dose by 2 times (the maximum daily dose per kg of body weight is 60 mg of amoxicillin and 15 mg of clavulanic acid).

The duration of therapy is determined by the severity of the infection. The drug should not be used unnecessarily for longer than 14 days.

With functional disorders of the kidneys, the excretion of active substances in the urine slows down. Therefore, the dose of the drug (calculated for amoxicillin), depending on the severity of renal failure, should not exceed:

• Creatinine clearance 10-30 ml per minute: adults – 2 times a day, 500 mg: children – 2 times a day, 15 mg/kg;
• Creatinine clearance up to 10 ml per minute: adults – 500 mg per day; children – 15 mg/kg per day.

For hemodialysis, adults are advised to take the drug in a daily dose of 500 mg, for children - 15 mg/kg. The same dose is taken during and after dialysis.

Flemoklav Solutab 875 mg/125 mg is prescribed only when the glomerular filtration rate is more than 30 ml per minute (without dose adjustment).

In case of functional liver disorders, the drug should be used with caution (under monitoring of liver function).

Pharmacokinetics

When studying the instructions for use of “Flemoclav Solutab” (875 mg + 125 mg), you need to pay attention to how this substance is absorbed by the body.

Both components are very quickly absorbed from the gastrointestinal tract, and this process is not affected in any way by food. The maximum concentration is reached after 25 minutes.

Amoxicillin binds to plasma proteins by 17-20%, and clavulanic acid by 22-30%. Both components are metabolized in the liver. But in different concentrations: clavulanic acid by 50%, and amoxicillin by 10%.

Substances are excreted primarily by the kidneys, through tubular secretion and glomerular filtration. Approximately 50-78% and 25-40% of amoxicillin and acid leave the body unchanged in the next 6 hours after taking the tablet.

Instructions for Flemoclav Solutab

Instructions for use Flemoklav Solutab recommends that adults, children under 12 years of age and children under twelve years of age weighing more than 40 kilograms take this antibiotic at a dose of 875+125 mg (total dose of active ingredients - 1000 mg) twice a day (for chronic, severe, for recurrent infectious diseases, double the dose).

Children under 12 years of age and weighing less than 40 kilograms are prescribed the drug in weaker dosages (Flemoklav 250 mg + 62.5 mg and Flemoklav 500 mg + 125 mg).

For adults and children weighing over 40 kilograms, Flemoclav Solutab 500 mg + 125 mg three times a day is recommended.

The daily dose for children under 12 years of age and weighing up to 40 kilograms is 5 mg of clavulanic acid and 25 mg of amoxicillin per kilogram of weight.

In severe infectious and inflammatory diseases, these doses can be doubled, but it is prohibited to exceed the dose of 60 mg of amoxicillin and 15 mg of clavulanic acid per kilogram of body weight per day.

The duration of treatment with the drug should not exceed two weeks.

In patients with concomitant renal failure, Flemoclav Solutab 875 mg/125 mg can be used if the renal filtration rate is more than 30 ml per minute.

To reduce the risk of side effects from the digestive system, it is recommended to take the drug immediately before meals. The tablet must be swallowed whole with water, or dissolved in 50 ml of water, stirring completely before use.

Indications

Having studied the composition of Flemoclav Solutab, as well as the features relating to its interaction with the human body, we can move on to discussing the conditions for which this substance is usually prescribed. The list is as follows:

• Lower respiratory tract infections. These are usually lung abscess, pleural empyema, pneumonia and bronchitis.
• Infections of the pelvic organs and genitourinary system. These include pyelonephritis, gonorrhea, pyelitis, chancroid, cystitis, pelvioperitonitis, urethritis, puerperal sepsis, prostatitis, septic abortion, cervicitis, salpingitis, bacterial vaginitis, salpingoophoritis, endometritis and tubo-ovarian abscess.

In addition, the indications of Flemoclav Solutab include the prevention of infections in surgery. It is also worth recalling that the above diseases can be caused by a variety of bacteria, and the medication under discussion is prescribed for their treatment only if the pathogen is susceptible to its composition.

Contraindications

The instructions for use of Flemoklav Solutab (875 mg + 125 mg) state that it is strictly forbidden to use this medication in the presence of the following conditions:

• Liver problems caused by taking clavulanic acid or amoxicillin.
• Episodes of jaundice.
• Infectious mononucleosis, including the one that occurs with a measles-like rash.
• Hypersensitivity to the components of the drug, as well as to any other antibiotics of beta-lactam origin.
• Phenylketonuria.
• The QC indicator is less than 30 ml/min.

Composition and action

The medication is considered a broad-spectrum antimicrobial agent. It is included in the penicillin category. The active ingredients are amoxicillin 250 mg and clavulanic acid 62.5 mg. The composition contains additional ingredients in the form of cellulose, crospovidone, vanillin, saccharin, and apricot flavoring.

The therapeutic properties of the drug are based on the destruction of pathogenic flora, which led to inflammatory disease of the kidneys and bladder. It has a wide spectrum thanks to clavulanic acid.

Relative contraindications

With great caution, the doctor may prescribe tablets for the following conditions:

• Lactation period and pregnancy.
• Chronic renal failure.
• Diseases of the gastrointestinal tract, even in history (especially if it is colitis resulting from the use of penicillins).
• Severe liver failure.

In these cases, the drug is prescribed in minimally effective dosages, and only if the potential benefit outweighs the likely risk.

Dosage

Typically, all patients over 12 years of age, and necessarily with a body weight of more than 40 kg, are prescribed 500 mg twice a day, or 250 mg three times a day.

However, now we are talking about a more powerful form of release - each tablet contains 875 mg of the active substance. And they need to be taken twice a day for respiratory tract infections or severe illnesses.

It should be remembered that the maximum daily dose for all patients is 6 g.

What about the duration of treatment? It is always determined on an individual basis. But, as a rule, the course does not last more than 14 days. And if a person is diagnosed with otitis media, then 10 days will be enough.

In order to prevent postoperative infections, Flemoclav 875 mg is not used - in such cases, the injection form is used.

Doctors adhere to a special approach when treating people with chronic renal failure - in their case, it is important to correctly determine the frequency of administration and adjust the dose, depending on the QC indicator.

Rules of application

Instructions for use of Flemoklav Solutab imply strict adherence to dosages. It is recommended to use the antibiotic in adult patients and children under 12 years of age for inflammatory processes in the throat. The total amount of clavulanic acid and amoxicillin should be 1000 mg twice daily. This dosage is appropriate for the treatment of chronic and severe types of infection. For repeated infections, the dosage may be increased.

For children under 12 years of age, as well as with low body weight (up to 40 kg), Flemoclav at a dosage of 250 mg and 500 mg is prescribed with great caution. The total dose of the drug per day should be no more than 25 mg of amoxicillin and 5 mg of clavulanic acid.

Flemoklav Solutab is prescribed to children in the following dosages:

• children over 7 and adults - dosage 250 mg three times a day;
• children from 2 to 7 years old - the dosage is 125 mg, three times a day;
• young children from 3 months to 2 years are prescribed tablets at a dosage of 125 mg twice a day.

The course of therapy with Flemoklav is no more than 14 days. If there is no effect, you should contact your doctor for advice. It is possible that bacterial cultures are not sensitive to amoxicillin.

In order to minimize the risk of developing side effects from taking an antibiotic in the digestive tract, doctors recommend taking it in combination with drugs that normalize the intestinal microflora: Lactobacterin, Bifidumbacterin.

Taking Flemoklav during pregnancy

During clinical studies, no negative effects of Flemoclav on the body of the fetus or pregnant woman were identified. The use of the drug in the first trimester of pregnancy is not recommended. In the subsequent months of pregnancy, the use of the drug must be agreed with your doctor.

Side effects

Ignoring the instructions supplied with the drug "Flemoclav Solutab" (875 + 125) may result in unwanted reactions. Among them:

• Hematopoietic organs: hemolytic anemia, thrombocytopenia, agranulocytosis, thrombocytosis, leukopenia, eosinophilia, increased prothrombin time, and bleeding.
• Allergic reactions: exanthematous pustulosis, urticaria, serum sickness, erythematous rashes, allergic vasculitis, exudative or malignant erythema multiforme, exfoliative dermatitis, angioedema and anaphylactic shock.
• Gastrointestinal tract: darkening of the enamel, nausea and vomiting, black “hairy” tongue, diarrhea, enterocolitis, gastritis, hemorrhagic and pseudomembranous colitis, stomatitis, liver failure, glossitis, hepatitis, increased activity of liver transaminases, very rarely – cholestatic jaundice.
• Nervous system: convulsions, dizziness, changes in habitual behavior, headache, anxiety and hyperactivity.
• Other: hematuria, candidiasis, crystalluria, interstitial neuritis and superinfection.

To avoid problems that may result from ignoring medical instructions, you need to take Flemoklav Solutab (875 + 125) strictly according to the prescribed therapeutic regimen.

It is important to know

Having discussed the side effects of Flemoclav Solutab, we can move on to describe other significant nuances regarding this topic. There are a lot of them, but the most important ones are worth highlighting in the following list:

• During treatment, it is necessary to monitor the condition of the kidneys, liver and function of the hematopoietic organs.
• To reduce the risk of adverse reactions from the gastrointestinal tract, you need to take this medication with meals.
• Under the influence of the tablets, the microflora, which is not sensitive to them, grows. Often this turns out to be fraught with the development of superinfection. Accordingly, in such cases it is necessary to change antibacterial therapy.
• Due to treatment with Flemoclav, urine glucose tests are often false positive. Therefore, if they are necessary, it is better to opt for the glucose oxidative method.
• People with hypersensitivity to penicillins often develop cross-type allergic reactions with cephalosporins.

It will also be useful to know that the drug “Flemoclav Solutab” is also prescribed to children, but in other forms. Children under 12 years of age can take drops, syrup and suspension.

How to use Flemoklav Solutab 250

The dosage is selected by the doctor based on the indications, the course of the disease and the individual characteristics of the body. Flemoklav with a dose of 250 mg is prescribed to children from 1 year to 12 years. In rare cases, it is used in women during pregnancy and adults weighing less than 40 kg.

Before use, the tablet must be dissolved in 1 tsp. water. There shouldn't be any lumps. Take the medicine with plenty of liquid.

Take the medicine with plenty of liquid.

For urinary tract and kidney infections

Adults with damage to the kidneys and urinary tract are prescribed 250 mg of the drug. Frequency of application: four times a day. The intervals between doses should be equal and be 6 hours.

For cystitis

For inflammation in the bladder, 250 mg is prescribed. Frequency of use: three times a day. The break between doses is 8 hours. The medicine should be taken after meals.

For urethritis

If the urethra is infected, the patient is advised to take the drug 250 mg 4 times a day. This scheme should be followed for 3 days. Then the dose is reduced to 250 ml three times a day.

Pyelonephritis

For pyelonephritis, the daily dosage of the medication is 3 g. Therefore, it is inconvenient to use the drug at a dosage of 250 mg. In such situations, Flemoclav Solutab 500 or 875 mg is suitable.

How many days to take

In case of uncomplicated inflammatory process, treatment lasts no more than 5 days. In severe cases, therapy is extended to 7-10 days.

In case of uncomplicated inflammatory process, Flemoclav Solutab 250 should be taken for no more than 5 days.

Drug interactions

Much in the instructions for use of “Flemoclav Solutab” (875 mg + 125 mg) is said about the chemical activity of this product. This is a strong drug that can have a variety of reactions with other medications. And here are just a few of the most common:

• "Flemoklav" increases the effectiveness of indirect anticoagulants. It impairs the synthesis of vitamin K, suppresses intestinal microflora, and also reduces the prothrombin index. If you need to combine these medications, you will have to keep blood clotting parameters under control.
• Bacteriostatic medications have an antagonistic effect. These are sulfonamides, tetracyclines, lincosamides, as well as macrolides and chloramphenicol.
• Due to laxatives, aminoglycosides, glucosamine and antacids, the absorption of Flamoclave is reduced. On the contrary, ascorbic acid increases it.
• The concentration of amoxicillin increases under the influence of diuretics, phenylbutazone, NSAIDs, allopurinol, and other drugs that block tubular secretion.
• Exposure to this antibiotic impairs the effectiveness of oral contraceptives, ethinyl estradiol, and medications whose metabolism leads to the formation of PABA. Moreover, by combining them with Flemoclav, you can increase the risk of breakthrough bleeding.
• The combination of this drug with allopurinol often leads to skin rashes.

And this is not the entire list of possible chemical reactions. That is why antibiotics are always prescribed only by a doctor - only he can prescribe a safe therapeutic regimen and tell how and with what this or that drug can be combined so as not to harm your health.

What are people saying?

"Flemoclav Solutab" really helps adults with sore throat and other diseases that are the reason for using this medication.

They say that the effect makes itself felt by the end of the first day of use. The temperature gradually subsides, other symptoms accompanying the disease soften, and overall health ultimately improves. The condition returns completely to normal after three days, but the course must be completed in full so that the disease does not return.

The most important thing is to strictly follow the instructions and take the medication as directed. Many people simply find pills in their home medicine cabinet that they once bought and begin to mindlessly drink them. And then they face a number of side effects.

Indications for use of Flemoklav Solutab 250

The drug is used for bacterial infections of the body.

The medicine is used to treat sore throat.

It is recommended for children and adults:

1. for sore throat, sinusitis, sinusitis, tonsillitis, pharyngitis;
2. with osteomyelitis;
3. with adnexitis, endometritis;
4. for streptoderma, boils and erysipelas;
5. with lesions of the genitourinary system;
6. for kidney and urinary tract infections.

Before you start taking the medication, you should visit a doctor to establish an accurate diagnosis and test for the sensitivity of the bacteria to amoxicillin.

Analogs

Many people believe that Flemoclav Solutab is overpriced. It’s worth mentioning right away that you can’t save on your health - it’s better to overpay several hundred for a high-quality, time-tested drug than to opt for a cheap product and then deal with the consequences, which will cost a lot more money.

However, sometimes a doctor may prescribe an analogue to a person for one reason or another. For example, if the original drug is difficult to find in local pharmacies, or the patient has individual contraindications. The most well-known alternatives include:

• "Amoxiclav".
• "Ecoclave".
• "Panklav 2X".
• "Augmentin".
• "Medoclav".
• "Betaclave."
• "Klamosar".
• "Arlet."
• "Verklav".
• "Foraklav".
• "Ranklav".
• "Fibell."
• "Rapiklav."
• "Bactoclav."
• "Amovicombe."
• "Novaclave."
• "Amoxivan."

These are complete analogues of “Flemoclav Solutab” in substance. And not all, but only the most famous.

Alternatives for action

In addition to the above, there are also medications that differ in composition, but are prescribed by a doctor for the same indications as Flemoklav. They affect the body in a similar way:

• "Sultasin."
• "Flemoxin Solutab".
• "Ospamox".
• "Cephurus".
• Amoxicillin Sandoz.
• "Ecoball".
• "Axoseph."
• "Ampicillin-Ferein".
• "Amosin".
• "Oxamp sodium."
• "Zinnat".
• "Cefuroxime Kabi".
• "Zinacef".
• "Sextaphage."
• "Esparoxy."
• "Roxithromycin."
• "Tsifran OD".

And again, this is not the entire list. The pharmaceutical market is very rich in alternatives. But only a doctor can prescribe an effective and harmless drug to a patient, and only after conducting an examination and studying his tests and medical history.