Farmazolin N

pharmachologic effect

The active ingredient is xylometazoline, which is a non-selective α-adrenergic agonist. Compounds of this kind help to reduce the diameter of the vessels of the mucous membranes and temporarily reduce the intensity of the manifestations of the inflammatory process. Thus, when applied topically they:

• exhibit an anti-edematous effect;
• reduce hyperemia (excessive blood filling of small vessels) and exudation (the release of fluid rich in proteins, leukocytes, platelets and other blood elements from the capillaries into the tissue);
• facilitate nasal breathing;
• reduce the intensity of blood circulation in the sinuses of the dura mater.

Xylometazoline has an exclusively local effect, that is, it practically does not penetrate into the systemic bloodstream through the mucous membranes, due to which it does not affect the body as a whole.

After using Farmazolin, relief occurs literally within 5–10 minutes and lasts up to 5–6 hours. For adults, the medicine is available in the form of drops and sprays with a xylometazoline concentration of 0.1%.

In addition to xylometazoline, the drug contains a number of excipients that ensure its stability, these are:

• water for injections;
• sorbitol;
• EDTA;
• sodium dihydrogen phosphate and sodium hydrogen orthophosphate;
• Decamethoxin.

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Instructions for use Farmazolin n (Spray): description, composition, FTG, INN

active substance:

xylometazoline hydrochloride;

1 ml of the drug contains xylometazoline hydrochloride in terms of 100% substance 1 mg;

Excipients:

benzalkonium chloride; sodium chloride; sodium dihydrogen phosphate dihydrate; disodium phosphate dodecahydrate; water for injections.

Drug classification code

Decongestants and other drugs for the treatment of nasal diseases for external use. Sympathomimetics. ATC code R01A A07.

Pharmacological properties

Xylometazoline is a sympathomimetic agent that acts on α-adrenergic receptors.

Farmazolin N leads to a narrowing of the nasal blood vessels, reducing swelling of the nasal mucosa and paranasal sinuses, and thus improving nasal breathing with congestion in the nose and paranasal sinuses.

The effect of the drug begins a few minutes after use and lasts up to 12 hours.

The drug is well tolerated, including in patients with sensitive mucous membranes. The drug does not reduce mucociliary function. Farmazolin N has a balanced pH value within the limits characteristic of the nasal cavity.

When applied topically, the concentrations of xylometazoline in the blood plasma are so small that they cannot be determined by modern analytical methods.

Indications for use

Symptomatic treatment of nasal congestion due to colds, hay fever, allergic rhinitis, sinusitis.

To facilitate the outflow of secretions in diseases of the paranasal sinuses.

Adjuvant therapy in cases of otitis media (to eliminate swelling of the mucous membrane).

To facilitate rhinoscopy.

Directions for use and dosage

For adults and children over 6 years of age, administer 1 injection into each nostril 3-4 times a day. The maximum daily dose is 4 injections. The duration of treatment depends on the course of the disease and should not exceed 7 days.

Immediately before use, you should hold the bottle with the drug in your palm to warm it to body temperature. When using the drug, keep the bottle vertically, with the sprayer facing up. Before use, remove the protective cap of the bottle, place the tip in the nasal passage, squeeze the bottle with a short sharp movement and, removing the tip from the nose, unclench it. During injection, it is recommended to inhale slightly through the nose. After using the drug, close the bottle with a protective cap and store according to the recommendations specified in the instructions.

Indications for use

The medication is used to relieve symptoms:

• acute rhinitis of any origin;
• allergic rhinitis, including hay fever;
• sinusitis and other types of sinusitis;
• otitis media

When considering the list of things that Farmazolin drops help with, we must not forget about the possibility of its use to prevent the development of swelling after any diagnostic and surgical procedures on the nasal cavity and passages.

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Contraindications and adverse reactions

Since xylometazoline exhibits pronounced vasoconstrictor properties, it is not recommended for use in:

• closed-angle form of glaucoma;
• atrophic rhinitis;
• hypertension;
• advanced atherosclerosis;
• thyrotoxicosis;
• tachycardia.

Attention! If you have developed any allergic reactions in the past to nasal drops containing xylometazoline (Evkazolin, Tizin Xylo, Nazik, Otrivin, Galazolin, etc.), the use of Farmazolin is prohibited.

Compatibility with other drugs

The possibility of using the drug while taking other medications deserves special attention, since some can enhance or, conversely, weaken its effect. Therefore, it is necessary to first consult a doctor if the patient uses:

• adrenolytics;
• sympatholytics;
• calcium antagonists;
• adrenomimetics.

In addition, if the patient takes certain pills, in particular tricyclic antidepressants or MAO inhibitors, consultation with the attending physician is required, since Farmazolin potentiates their hypertensive effect. Source: nasmorkam.net

After instilling the drug into the nose in therapeutic doses, side effects rarely develop. However, sometimes patients complain of the following sensations:

• burning;
• dryness;
• tingling.

With uncontrolled prolonged use, the following may occur:

• edema;
• increased blood pressure;
• dizziness;
• sleep problems;
• headache;
• bouts of vomiting;
• arrhythmia;
• short-term visual impairment;
• tachycardia;
• depressive states.

If the patient experiences any of the listed side effects, you should immediately stop using Farmazolin, consult a physician as soon as possible and find out the cause of their occurrence. To eliminate undesirable consequences, the following are usually used:

• sympatholytics (Isobarin, Ismelin, Octadine, Rausedil, Reserpine, Adelfan, etc.);
• α-blockers (Phentolamine, Tropaphen, Prazosin hydrochloride, etc.).

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Phoenix Health

INSTRUCTIONS for medical use of the drug

The content of the article:

Registration number:

Trade name of the drug:

Farmazolin®

International Nonproprietary Name (INN):

xylometazoline.

Dosage form:

nasal spray

Compound:

1 ml of solution contains: Active substance: xylometazoline hydrochloride - 0.001 g.

Excipients: benzalkonium chloride, sodium chloride, sodium phosphate monosubstituted 2-water, sodium phosphate disubstituted 12-water. water for injections.

Description:

transparent colorless liquid.

Pharmacotherapeutic group:

alpha adrenergic agonist.

ATX Code:

[R01AA07].

Pharmacological properties:

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes constriction of the blood vessels of the nasal mucosa, thus eliminating swelling and hyperemia of the nasal mucosa, restores the patency of the nasal passages, and facilitates nasal breathing.

The effect of the drug begins a few minutes after its use and lasts up to 10 hours.

Pharmacokinetics: When applied topically, the drug is practically not absorbed, so its concentration in the blood plasma is very low (not determined by modern analytical methods).

Indications for use:

Acute respiratory diseases with symptoms of rhinitis (runny nose), acute allergic rhinitis, hay fever, sinusitis, eustachitis, otitis media (as part of combination therapy to reduce swelling of the nasopharyngeal mucosa), to facilitate rhinoscopy.

Contraindications:

Hypersensitivity to xylometazoline, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, hyperthyroidism, surgical interventions on the meninges (history), pregnancy, lactation, children under 12 years of age.

Do not use during therapy with MAOIs and tricyclic antidepressants.

Use caution if you have diabetes.

Directions for use and dosage:

Adults and children over 12 years of age are given 1 injection into each nasal passage (can be repeated if necessary); should not be used more than 3 times a day. Do not use the drug without a break for more than 5-7 days.

Side effects:

With frequent and/or prolonged use - irritation and/or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion; rarely - swelling of the nasal mucosa, vomiting, headache, palpitations, increased blood pressure, insomnia, blurred vision, depression (with long-term use of high doses).

Overdose:

Symptoms: increased side effects. Treatment: symptomatic under medical supervision.

Interaction with other drugs:

It is possible to enhance the systemic effect with simultaneous use of MAO inhibitors and tricyclic antidepressants.

Special instructions:

The drug should not be used for a long time, for example, with chronic rhinitis.

Effect on the ability to drive a vehicle or equipment:

Xylometazoline, in dosages higher than recommended, may affect the ability to drive a vehicle or operate equipment, causing the symptoms described in the "Side Effects" section.

Release form:

15 or 20 ml in a polyethylene bottle with a capacity of 25 ml, equipped with a nozzle with a dispenser and a protective cap, enclosed in a pack along with instructions for medical use.

Storage conditions.

Store in a place protected from light and out of reach of children at a temperature not exceeding 25 °C.

Best before date.

2 years. Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies.

Over the counter.

. 04080, Ukraine, Kiev, st. Frunze, 63.

Comments

(visible only to specialists verified by the MEDI RU editorial team)

Source: medi.ru

Use during pregnancy and lactation

Farmazolin can be used during pregnancy and lactation, but only as prescribed by a doctor. But you should still pay special attention to how to use the drug, and not exceed the recommended frequency of administration and doses.

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Farmazolin for children: treating a child’s nose

A separate drug Farmazolin for children has been created for children . In it, the concentration of the active substance is reduced to 0.05%. It is indicated for use in children from six months to 6 years.

The medicine is administered into each nostril 1-2 drops twice a day for 3-5 days. When treating infants, it is recommended to carry out manipulations before feeding or going to bed.

You cannot use the medication for longer than 7 days!

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Instructions for use (Method and dosage)

Before administering the product, the instructions for Farmazolin recommend thoroughly cleaning the nasal cavity.

When using a polyethylene bottle, screw the cap as much as possible before the first instillation. In this case, the spike located on its reverse side pierces a hole. Then the cap is unscrewed, removed and, pressing on the body of the bottle, the solution is instilled into the nose.

Farmazolin (children) 0.05%, used at the age of 1-11 years. Farmazolin 0.1%, used from the age of 12 years.

Farmazolin (nasal drops) for children, instructions for use

• Children 1-5 years old are prescribed to instill (under adult supervision) 1-2 drops into both nasal passages up to three times per day.
• Children 6-11 years old are recommended to instill (under adult supervision) 2-3 drops into both nasal passages up to three times per nose.

This form of the drug in the specified age groups is allowed to be used no more than 3 times a day. The duration of treatment depends on the duration of the disease and should not exceed 1 week, unless otherwise prescribed by the doctor.

Farmazolin drops, instructions for use

For persons over 12 years of age, 2-4 drops are recommended in both nasal passages up to three times per day. The duration of treatment depends on the form and course of the disease and should not last more than 10 days in a row.

Features of using drops and spray

Regardless of the choice of dosage form of the drug, before using it, it is recommended to clean the nasal passages by rinsing them with saline solutions. These may include:

• Aqua Maris;
• Humer;
• Marimer;
• Aqualor;
• Dolphin;
• Salin;
• Quicks;
• No-salt;
• saline;
• saline solution prepared at home by dissolving 1 tsp. sea ​​salt in 400 ml of boiled water.

Attention! When treating children under one year of age, the spray should not be used. All medications are administered into the nose only in the form of drops, including saline solutions.

If the choice fell on drops, before the 1st use you should screw the cap tightly so that the pointed protrusion located on its inside pierces the tip of the polyethylene bottle.

After this, the cap is removed, the solution is instilled into the nasal passages in therapeutic doses (for children over 12 years of age and adults - 1-3 drops up to 3 times a day) and the bottle is tightly closed.

is produced under the trade name Farmazolin N. Many people prefer to use the drug in this form because of its ease of use. It is recommended to use it from the age of 12, 1 injection into each nostril up to 3 times a day.

When treating sinusitis and otitis, ENT specialists advise using a combination of the drugs Farmazolin and Dioxidin, since the latter has anti-inflammatory properties and also accelerates the healing and restoration processes of the mucous membrane.

In any case, Farmazolin should not be used for more than 7 days, since this is fraught with the development of addiction and the so-called drug-induced rhinitis, in which swelling will be constantly present until new doses of xylometazoline are administered.

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Farmazolin: instructions for use of nasal drops and spray for children and adults, analogues

Treatment of diseases of the nasal area and pulmonary system with Farmazolin, according to the instructions for use, is quick and effective. However, everything has its price. So, this drug has a number of contraindications and side effects, which are important to know about before you start taking it.

Composition and release form

The original drug, marketed under the brand name "Farmazolin", is produced in two forms: in drops and in a spray. And each of them has its own distinctive features.

Farmazolin drops

The pharmacological agent is a clear liquid without a specific color. It is produced in soft polyethylene bottles with a volume of 5 or 10 milliliters.

According to their composition, drops are also divided into 2 types:

1. With a concentration of xylometozoline hydrochloride of 0.5 milligrams.
2. Contains 1 milligram of the main component.

Otherwise they are identical to each other and include:

• Mono- and disubstituted sodium phosphate.
• Sorbitol.
• Trilon B.
• Decamethoxin.
• Purified water.

Farmazolin spray

The drug is based on the substance xylometozoline hydrochloride, weighing 0.001 grams per 1 milliliter of the drug. The rest of the volume falls on auxiliary components:

• Sodium phosphate, disubstituted and monosubstituted.
• Benzalkonium chloride.
• Sodium chloride.
• Water.

In appearance, the solution is a transparent liquid without a specific color. For sale, it is bottled in 25-milliliter bottles of 15 or 20 units.

pharmachologic effect

The main component of the drug, xylometozaline, is an alpha-level adrenergic agonist. Due to this, Farmazolin has the ability to locally act on the mucous membrane of the nasal cavity:

• Reduces inflammation.
• Constricts peripheral blood vessels.
• Even relieves severe swelling.
• Facilitates nasal breathing.

When used correctly, 99% of medicinal substances are not absorbed into the blood and only affect the body locally.

The effect of application becomes noticeable within a few minutes. In different cases, it can last differently - from 2-3 to 7-8 hours.

Instructions for use

The pharmacological agent Farmazolin is intended exclusively for irrigation of the nasal passages and cannot be used in any other way. Before using it, you must remove the protective cap from the bottle. For each type and dosage of medication, this procedure is carried out differently, in accordance with the instructions for use that come with the kit.

Farmazolin for children

This product is strictly forbidden to be given to children under 2 years of age, regardless of its form of release.

Children under 5 years of age are indicated for treatment with Farmazolin 0.05% drops. To combat the symptoms of the disease, 1-2 drops in each nasal passage 1-2 times a day are enough.

Farmazolin nasal drops: doses

Adults and children over 5 years of age are advised to use the 1% version of the medicine. It should be instilled into both nasal passages, 1-2 drops 2-3 times a day, depending on the doctor’s prescription.

The total duration of treatment should not exceed 5 days.

Dosage and use of spray

Farmazolin 0.001% can be used to treat adults and children over 12 years of age. The therapeutic dose consists of 1 injection into each nasal passage. You can repeat it no more than three times a day, for 5-7 days.

Interaction with other drugs

An important feature of the drug is that it acts exclusively locally and therefore does not enter the body’s circulatory system. Due to this, the level of its interaction with other drugs is very low.

However, before you start taking several pharmaceutical drugs in combination, you should consult your doctor. This is due to the fact that some adrenergic agonists can enhance the effect of Farmazolin. At the same time, sympatholytics weaken its effectiveness and can even reduce it to zero.

Terms of sale

In the Russian Federation, the drug is sold in pharmacies without a doctor's prescription, regardless of the form of its release.

Storage and shelf life

Farmazolin drops or spray should be stored in the original packaging, in a dark and dry place, at a temperature of 15 to 25 degrees Celsius.

The shelf life of the drug is 36 months from the date of production.

Analogs

In Russian pharmacies you can find many products similar to Farmazolin in their action. These include:

• Imidine.
• Xylene.
• For the nose.
• Otrivin.
• Galazolin and others.

Moreover, each of these medicines may have its own concentration of the main active substance and its own application characteristics.

Kalashnik Yulia

Source: https://VipLor.ru/preparaty/farmazolin-instruktsiya

Is it possible to drip Farmazolin into the eyes?

You can often find recommendations to drip vasoconstrictor drops, in particular Farmazolin, into the eyes to relieve signs of fatigue, redness, etc.

Indeed, after instilling such remedies, the traces of a sleepless night or long work at the computer disappear as if by hand. The whites of the eyes become snow-white, and thanks to this the face looks fresh and rested.

This effect is due to the vasoconstrictor effect of the drug, so the capillaries overflowing with blood, which give the eye redness, narrow and become invisible. But experienced ophthalmologists categorically prohibit resorting to this method, since vasoconstrictors can damage the cornea of ​​the eye and cause the development of serious ophthalmic pathologies, some of which can only be treated surgically.[ads-pc-1][ads-mob-1] to content ?