Cold and flu medicine ibuklin

Composition and action

Ibuklin is a combination drug that includes:

• propionic acid derivative (ibuprofen);
• a substance from the anilide group (paracetamol).

These components belong to non-steroidal anti-inflammatory drugs, or non-narcotic analgesics. In addition to active ingredients, Ibuklin contains auxiliary components (corn starch, silicon dioxide, talc, etc.).

Has the following effects:

1. Painkiller.
2. Antipyretic.
3. Anti-inflammatory.

Both paracetamol and ibuprofen inhibit prostaglandin synthesis by inhibiting the activity of cyclooxygenase, which is a key point in the pharmacological action of Ibuklin.

pharmachologic effect

Ibuprofen is characterized by pronounced antipyretic, analgesic and anti-inflammatory properties. By blocking the enzyme cyclooxygenase, it reduces the amount of PGs - mediators of pain and inflammation. The substance reduces inflammatory exudation, which helps relieve swelling (in particular, in case of joint diseases). Paracetamol is also a COX blocker. It effectively relieves pain and reduces fever. The effects of the drug components are mutually reinforcing.

After taking the tablets orally, the components are absorbed quickly, almost completely. Their maximum plasma concentration is recorded after 1-2 hours. Unchanged substances, their metabolites and conjugates are excreted primarily in the urine (a relatively small amount is excreted in bile).

Use for influenza

The main indications for the use of Ibuklin for influenza are:

• fever with an axillary (axillary) temperature value of more than 38.5–39 °C;
• fever above 38 °C in children with congenital heart defects, hereditary metabolic abnormalities, pathology of the respiratory system, or a history of febrile convulsions;
• “white” hyperthermia (as a primary antipyretic).

Feverish syndrome is the main, but not the only condition that Ibuklin can relieve. The drug is also effective in eliminating headaches, which are very painful with the flu, cause significant discomfort to patients, and cause sleep disturbances .

When should I take Ibuklin?

The tablets should not be taken if an acute respiratory viral infection or a cold has not caused an increase in body temperature; complications after such experiments can be very serious, regardless of the patient’s age and body weight.

When is Ibuklin recommended for the flu?

1. If, when measuring the temperature under the armpit, the thermometer showed more than 38.5 degrees.
2. If a fever is tormenting a child who has also been diagnosed with a heart defect, has hereditary metabolic pathologies, or has a history of febrile convulsions.
3. If high fever, weakness and loss of strength persist for a long time and it is not possible to get rid of these manifestations using the usual methods. The medicine will relieve painful headaches and provide the patient with healthy sleep.

Despite the fact that in this article we establish methods of action and proper administration of Ibuklin for colds, it should be noted that the medicine copes well with pain.

Contraindications and application features

Among the contraindications to taking Ibuklin are the following:

1. Individual sensitivity to any component of the drug - both primary and additional.
2. Hypersensitivity to salicylates, bronchial asthma, nasal polyposis.
3. Erosive and ulcerative lesions of the digestive tract in the acute stage.
4. Insufficiency of kidney and liver function.
5. Optic nerve damage.
6. Glucose-6-phosphate dehydrogenase deficiency.
7. Hyperkalemia confirmed clinically and laboratory methods.
8. The recovery period after coronary artery bypass surgery.
9. Pathology of the blood system.

Ibuklin in the classic dosage version should not be taken by children under 12 years of age or by women in the third trimester of pregnancy. Children of the younger age group are prescribed children's forms of Ibuklin (Ibuklin Junior).

If there is a need for use in a nursing mother, breastfeeding should be discontinued. The effect on the fetus has not been studied, therefore the use of Ibuklin by pregnant patients is permissible only as prescribed by a doctor.

Contraindications

Ibuklin, as an antipyretic, is strictly contraindicated if the patient is individually intolerant of its active substances, which cause allergic reactions in him.

Due to the fact that the drug can negatively affect the condition of the gastric and intestinal mucosa, it is contraindicated for use if the patient has any gastrointestinal diseases that are in the form of an exacerbation. This includes stomach ulcers, erosive intestinal lesions, pancreatitis, etc.

The next contraindication is the patient’s pregnancy. In this case, Ibuklin can be prescribed only when the expected benefit for the mother exceeds the possible negative consequences for the fetus. The same applies to treatment with this drug during lactation.

Due to the risk of negative effects on the body, Ibuklin is prohibited for use in children under three years of age. At this age, the child should use safer antipyretic drugs.

Children under 3 years of age are prohibited from taking Ibuklin

This medicine should be used strictly as directed and only under the supervision of a doctor (with caution) in the following cases:

1. Old age of the patient.

2. The patient has concomitant severe chronic diseases (diabetes mellitus, chronic renal or liver failure, asthma, etc.).

3. Intragastric or intraintestinal bleeding, which is in the acute phase.

4. Chronic heart failure.

5. Blood clotting disorder.

6. Concurrent use of potent medications.

Side effects

Ibuklin can cause gastropathy associated with taking non-steroidal anti-inflammatory drugs, has an adverse effect on the pancreas, and is characterized by hepatotoxicity. Possible side effects also include:

• headache;
• drowsiness;
• hearing loss;
• anemia;
• skin rash, etc.

To reduce the risk of side effects, contraindications must be taken into account and the dose of Ibuklin should not be exceeded.

Ibuklin tablets: instructions for use

Self-medication can be harmful to your health. You should consult your doctor and read the instructions before use.

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ibuprofen 400 mg, paracetamol 325 mg.

Excipients

: Corn starch, microcrystalline cellulose, talc, sodium glycolate, colloidal silicon oxide, magnesium stearate, hydroxypropyl methylcellulose, polyethylene glycol, sunset yellow, titanium dioxide, sorbic acid, polysorbate, dimethicone.

Pregnancy and lactation

During pregnancy and lactation, the use of the drug is not recommended. If it is necessary to take it during lactation, it is necessary to decide on the transfer to artificial feeding.

Directions for use and doses

Adults Ibuklin are usually prescribed one tablet 3 times a day after meals. The maximum single dose is 2 tablets. The maximum daily dose is 6 tablets. In case of impaired renal or liver function, the interval between doses of the drug should be at least 8 hours. The drug should not be taken for more than 5 days as an analgesic and for more than 3 days as an antipyretic without medical supervision.

Side effect

– Digestive organs: nausea, loss of appetite, vomiting, possible development of erosive and ulcerative lesions of the gastrointestinal tract; with long-term use, liver function may be impaired.

– Central nervous system: headache, dizziness, sleep disturbance, agitation, visual impairment (impaired color perception, scotoma, amblyopia).

– Hematopoiesis: with long-term use: anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis.

– Urinary system: with prolonged use, renal function may be impaired.

-Allergic reactions: skin rash, Quincke's edema, rarely aseptic meningitis, bronchospastic syndrome.

All side (unusual) effects of the drug, including those not listed in these instructions, should be reported to your doctor.

Signs of acute poisoning are nausea, vomiting, stomach pain; in severe cases, liver failure and coma develop. If you suspect poisoning, you should immediately seek medical help; if less than 4 hours have passed since the poisoning, you can do a gastric lavage.

Interaction with other drugs

If you need to use Ibuklin while taking other medications, be sure to consult your doctor.

The combination of Ibuklin with other non-steroidal anti-inflammatory drugs, barbiturates, anticonvulsants, rifampicin, hypoglycemic drugs, and hormonal contraceptives should be avoided.

Use together with potassium-sparing diuretics may cause hyperkalemia. When used together, it is possible to increase the blood concentration of digoxin, phenytoin, methotrexate, and lithium. When used with metoclopramide, an increase in the concentration of paracetamol in the blood is possible. The hepatotoxic effect of both components may be enhanced by alcohol intake.

Precautionary measures

The drug is used with caution in elderly people, in patients with impaired liver or kidney function, with chronic heart failure, with dyspeptic symptoms before starting treatment, with a history of gastrointestinal bleeding and diseases of the digestive system, immediately after surgical interventions, when there is a history of allergic reactions associated with taking non-steroidal anti-inflammatory drugs, bronchial asthma, polyps of the nasal mucosa, as well as in persons receiving anticoagulant drugs and hypoglycemic drugs for oral administration.

Release form

The package contains 20 film-coated tablets with instructions for use.

Storage conditions

Store in a dry place, protected from light at temperatures up to 25°C. Keep out of the reach of children.

Best before date

5 years. Do not use after the expiration date stated on the packaging.

Reviews

In reviews of the action of Ibuklin, many patients indicate as an advantage the rapid antipyretic effect, which lasts for a long time and allows you to reduce drug intake and avoid accidental overdose. A pronounced analgesic effect is also noted. You can often find the formulation “the strongest antipyretic”, “the best remedy for fever, headaches and muscle aches”, “the most effective drug for fever for children”.

Among the disadvantages, the most often emphasized is the voluminous list of contraindications and possible side effects that are mentioned in the instructions for Ibuklin, a ban on use during pregnancy and breastfeeding.

Indications

Ibuklin is approved for use in the treatment of the following diseases and conditions:

1. Acute respiratory diseases of the respiratory system (influenza, ARVI).
2. Infectious forms of diseases of the upper respiratory tract, as well as tonsils.
3. An acute form of tonsillitis in children, which is accompanied by high fever and inflammation. In this case, the drug should be used as an adjuvant therapy.
4. Gout and various inflammatory diseases of the musculoskeletal system.
5. Inflammation of soft tissues and tendons that arise as a result of injury.
6. Toothache in adults.

Medicines for colds and flu - Ibuklin instructions

Ibuklin - instructions, application, price

Ibuklin instructions

The instructions accompanying the drug Ibuklin bring to the attention of the patient everything he needs to know about the form of release and composition of the drug, indications for use and contraindications for use, as well as a detailed dosage regimen.

Having studied the instructions for Ibuklin, the patient will be familiar with all its possible side effects and symptoms of overdose, as well as methods of its treatment.

In addition, anyone who is interested in the opinions of other people about the drug, in the final part of the accompanying sheet, will receive reviews from those who have already used Ibuklin in their treatment. Information about the cost of the medicine and its analogues is also available.

Form, composition, packaging

The drug Ibuklin is supplied to pharmacies in packs of thick cardboard, which may contain one, two or twenty blisters with ten tablets each.

The medicinal form of Ibuclina is represented by coated tablets, the color of which is orange. They are capsule-shaped and have a break for separation on one of their sides. Sometimes marbling is observed in the color character.

The active substance of the drug includes the required amount of ibuprofen and paracetamol. The medicine is auxiliary with microcrystalline cellulose, magnesium stearate, corn starch, talc, glycerol, colloidal silicon dioxide, sodium carboxymethyl starch type A.

The shell consists of the required proportions of hypromellose, dimethicone, sunset yellow dye E110, sorbic acid, aluminum varnish, polysorbate 80, macrogol 6000, titanium dioxide and talc.

Terms and conditions of storage

Storage of the drug should be organized in a place where there is no humidity and excessive light. The optimal storage temperature is 25 degrees. The term is no more than five years. Children are not allowed into storage areas and the drug should not be used if it has expired.

Pharmacology

Being a combined drug, Ibuklin affects the body in accordance with the properties that its constituent components have.

Thanks to ibuprofen, the drug is capable of analgesic, antipyretic and anti-inflammatory effects.

This component of the active substance of the drug inhibits cyclooxygenase enzymes, disrupting the metabolic processes of archadonic acid, as well as reducing the amount of pain, inflammatory mediators, as well as hyperthermic reactions. Similar activity occurs both at the site of direct inflammation and in unaffected tissues.

The participation of paracetamol also helps reduce fever and relieve pain, but the anti-inflammatory effect of this component is low.

By combining these components, their effectiveness is significantly increased. The active complex of the drug is capable of weakening arthralgia, both at rest and in motion, reducing stiffness in the morning, and swelling of the joints. With its use, the patient is able to increase the range of mobility.

Ibuprofen

The substance has high and complete absorption. Binding to plasma proteins occurs by 90 percent.

After active absorption, most of the substance undergoes conversion to the pharmacologically active form (C) from the inactive form (P), which occurs at a slow pace. Metabolism takes place.

Ibuprofen has the ability to penetrate into joint cavities and accumulate in synovial fluid, which leads to higher concentrations compared to plasma.

The half-life is two hours. Almost completely the substance is excreted by the kidneys (1% unchanged) and slightly through bile metabolites.

Paracetamol

The substance has the ability to be highly absorbent. Binding to plasma proteins occurs insignificantly (less than 10%). In liquid media, paracetamol is distributed uniformly. Penetrates through the blood-brain barrier.

The substance is almost completely metabolized, forming inactive conjugates and metabolites in the liver.

The half-life of paracetamol is no more than three hours. The kidneys excrete 5% of it, invariably the rest in the form of conjugates. Has negligible penetration into breast milk.

Special cases involve monitoring various categories of patients, which include the elderly, children and those suffering from cirrhosis of the liver.

Ibuklin indications for use

The drug is prescribed for the treatment of those patients who suffer from febrile conditions associated with influenza and ARVI. In addition, Ibuklin can be recommended for treatment for those patients who need therapy

• Myalgia;
• Algidysmenorrhea;
• Neuralgia;
• Toothaches;
• Back pain;
• Pain syndromes of a post-traumatic or postoperative nature;
• Joint pain and pain syndromes due to inflammatory ailments of the musculoskeletal system;
• Pain from sports injuries, sprains, dislocations, bruises, etc.

It should be remembered that Ibuklin is a drug for symptomatic therapy, which reduces inflammation and pain, but only at the time of its use. The progression of the disease is not reduced by its use.

Ibuklin instructions for use

The drug is to be taken orally several hours before or after meals. The tablet should not be crushed. Drink plenty of water.

For an adult patient, 1 piece is prescribed three times a day. Maximum of three tablets.

For adolescent patients over 12 years of age whose body weight exceeds 40 kilograms, 1 piece is prescribed twice a day.

In order to reduce fever, take Ibuklin for no more than three days.

For pain relief, Ibuklin can be taken for up to five days.

Longer use is possible only with the approval of a doctor.

Ibuklin during pregnancy

During pregnancy, Ibuklin is allowed to be taken only in the first and second trimesters. When prescribing the drug to an expectant mother, the possible risk and expected benefit should be balanced. During the last period of a woman’s condition, the drug is prohibited from being taken or prescribed. You should also not breastfeed during treatment.

Ibuklin for children

For children, Ibuklin has contraindications up to the age of twelve.

Ibuklin for the elderly

Ibuklin is prescribed to the elderly with great caution.

Drug interactions

Drug interactions with other medications can lead to very different effects from both drugs being combined.

• Acetylsalicylic acid – its effect, both anti-inflammatory and antiplatelet, is reduced;
• Ethanol, corticosteroids - increases the risk of erosions and ulcers in the gastrointestinal tract.
• Anticoagulants, thrombolytic agents, antiplatelet agents - their action increases and the risk of developing hemorrhagic complications increases.
• Insulin and oral hypoglycemic drugs – their effects are enhanced.
• Diuretics, antihypertensive drugs - their effect is weakened.
• Digoxin, lithium preparations and methotrexate - their concentration in the blood increases.
• Caffeine enhances the pain-relieving effect of ibuprofen.
• Gold preparations may increase nephrotoxicity.
• Antacids, when taken together with Ibuklin, lead to a decrease in its absorption.
• Myelotoxic drugs reveal the hematotoxicity of Ibuklin.

Additional instructions

You should not carry out simultaneous treatment with Ibuklin together with those medications that also contain paracetamol, even in small concentrations.

Long-term use of the drug for more than a week involves monitoring the functionality of the liver and the picture of peripheral blood.

Combining treatment with anticoagulants, the indirect action of which is fraught with changes in blood clotting parameters.

Do not use the drug with other NSAIDs.

Alcohol is prohibited during treatment with Ibuklin.

When taking Ibuklin, laboratory parameters may be distorted.

Care should be taken to limit driving and operating mechanical equipment to avoid serious traumatic situations.

Ibuklin analogues

The drug Ibuklin has several analogues that can replace the drug in treatment or continue it. Each of the analogue drugs has a tablet form: Ibuklin Junior, Khayrumat, Next, Brustan.

Ibuklin price

The cost of the drug is low and amounts to about 110 rubles per package with a dozen tablets.

Ibuklin reviews

The drug Ibuklin has extremely positive reviews and is considered one of the popular drugs for reducing fever and eliminating pain of various types. There are quite a few reviews worth noting, so here are excerpts from some of them.

Margarita: I consider Ibuklin a proven remedy against pain and high fever, so I always buy it for my first aid kit so that it is always at hand at the right time. My acquaintance with this medicine happened by accident.

When my husband had a toothache at night and a high fever, there was no peace in the house, and everyone tried to remember how else they could help him. It was necessary to hold out until the morning to go to the dentist. When the pain was unbearable, the man went out onto the landing.

The neighbors heard this fuss and, having learned about this kind of trouble, decided to help as best they could. Their help consisted of a small orange capsule called Ibuklin. It should be noted that after half an hour the exhausted husband fell asleep right in the chair, and it was noticeable that not only his pain had subsided, but also the fever had receded.

Since then, I have only used this remedy for pain and fever, and it has never failed.

Svetlana: I recently learned about the drug Ibuklin. My son fell ill with a sore throat accompanied by a high fever. However, the trouble is that he absolutely cannot stand any baby syrup with various flavors. Therefore, I had to consult a doctor.

He advised Ibuklin. The medicine is worthy, in my opinion, of all praise. Literally from the first dose, the fever subsided, and the treatment ended five days later with a complete recovery. Well, such a drug can have a place of honor in the medicine cabinet.

Source

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