Tsiprolet is an antibiotic of the fluoroquinol group. It has a strong bactericidal effect and a gentle effect on the composition of the gastrointestinal tract, does not lead to the development of candidiasis in the vaginal area. The drug is well and very quickly absorbed into the blood and acts almost immediately after use. It has an effect in the fight against various infectious and bacterial diseases.
Composition and release form
Release form
- Pills,
- Injection,
- Drops.
Composition of tablets
Ciprolet – 250: 1 film-coated tablet contains Ciprofloxacin 250.0 mg, Corn starch 57.87 mg, microcrystalline cellulose 7.5 mg, croscaramelose sodium 10.0 mg, colloidal silicon anhydrate 5.0 mg, talc 7.0 mg, magnesium stearate 3.510 mg, hypromellose 6.0 mg, sorbic acid 0.1 mg, titanium dioxide 2.5 mg, macrogol 1.7 mg, polysorbate 0.1 mg, dimethicone 0.1 mg
Ciprolet – 500: 1 film-coated tablet contains ciprofloxacin hydrochloride monohydrate in a dose equivalent to 500 mg of ciprofloxacin and excipients – microcrystalline cellulose 5.0 mg, croscaramelose sodium 20 mg, corn starch 37.25 mg, magnesium stearate 4.5 mg , colloidal silicon dioxide 5.0 mg, talc 8.5 mg, hypromellose 7.0 mg, sorbic acid 0.1 mg, titanium dioxide 2.5 mg, macrogol 1.7 mg, polysorbate 0.1 mg, dimethicone 0. 1 mg.
pharmachologic effect
This antibiotic is a powerful agent with an antibacterial effect. Ciprofloxacin is the active ingredient of the drug, which has an effect on the topoisomerase of bacteria that has entered the human body. By acting on bacterial DNA, the drug inhibits the cloning of microbial DNA. It doesn’t matter what stage of activity it is in (quiet, active), the drug affects the microorganism in any of its states.
Tsiprolet shows good results in the fight against infections caused by different types of pathogenic flora and bacteria. The drug successfully suppresses:
- Escherichia coli;
- salmonella;
- klebsiella;
- streptococcus, staphylococcus;
- mycoplasma
Fungi, ureaplasma, Clostridium, Treponema are endowed with good resistance to antibiotics. The positive side of Tsiprolet is its lack of influence on the chemical composition of the intestinal microflora; it does not allow the appearance of a dysbacteriosis state. Candidiasis and bacterial vaginosis also do not develop when women use the drug.
Once the drug enters the body, it is well absorbed by the gastrointestinal tract, more than 90%. Half an hour after taking the drug in tablets, the active ingredients of Tsiprolet are already entering the bloodstream. If the patient uses eye drops, the effect of the drug occurs after 10 minutes of administration, and intravenous injections - after seven minutes. Once the drug enters the body, it has an effect in the body for 12 hours. If the liver or kidneys are impaired, the effect of the medicine may be prolonged, which can lead to an overdose of the drug.
Tsifran or Tsiprolet, which is cheaper?
Cifran is an antibacterial agent from the group of fluoroquinolones. The active ingredients are ciprofloxacin and tinidazole. With this combination, the effect of the drug is enhanced. It exhibits not only antibacterial but also bactericidal properties. The medicine copes better with microbes and has a wider range of effects.
- twice a day with a dosage of 250 milligrams. Take 2 tablets at one time;
- once a day with a dosage of 500 milligrams, 2 tablets.
Tsifran costs 3 times more than Tsiprolet. If the first drug can be bought at a pharmacy for 70-120 rubles, then the second - for 220-360 rubles. It is up to the doctor to decide which medication is best to purchase to treat a sore throat.
Indications for use of Tsiprolet
This drug is used in the form of tablets or intravenous injections in the presence of the following bacterial diseases:
- respiratory organs - with acute chronic bronchitis, with pneumonia and bronchopneumonia, lung abscess, empyema, infectious pleurisy, infectious bronchiectasis, pulmonary infection occurring in parallel with cystic fibrosis changes in the lungs;
- genitourinary system – for the prostate, chronic and acute pyelonephritis, cystitis, epididymitis;
- ENT organs – for otitis media, sinusitis, mastoiditis;
- gynecology – for adnexitis, salpingitis, oophoritis, endometritis, pelvic abscess, pelvioperitonitis, infectious ulcer;
- for gonorrhea, which may include both rectal and urethral, pharyngeal localization of gonococcus lesions;
- abdominal cavity - with cholecystitis, peritonitis, intra-abdominal abscess, cholangitis, gallbladder epiema;
- joint, bones - with purulent arthritis, chronic and acute osteomyelitis;
- Gastrointestinal tract – for typhoid fever, bacterial diarrhea;
- with suppressed immunity;
- tissue and skin - for infectious wounds, burns, abscesses and cellulite.
Tsiprolet is used in drops for the following eye disorders:
- for bacterial keraconjunctivitis and keratitis, acute and subacute conjunctivitis, blepharitis, blepharoconjunctivitis, bacterial corneal ulcer + hypopyonoma, bacterial corneal ulcer, chronic meibomyitis and dacryocystitis;
- in the treatment of postoperative purulent-inflammatory infectious complications in the eyes;
- in case of eye damage several hours after injury or when a foreign body enters;
- in the preoperative period for prevention.
Tsipromed or Tsiprolet which is better
Despite the identical active ingredient (ciprofloxacin), Tsipromed and Tsiprolet differ in their scope of application and release form.
The first remedy is effective for eye diseases and pathologies of the hearing aid caused by a bacterial provocateur; Available in the form of drops with antibacterial properties.
The second is effective for sore throat and tonsillitis of identical origin; it is produced in the form of tablets and liquid for injection.
Tsipromed is an effective prescription for otitis media accompanying bacterial tonsillitis. The use of ciprofloxacin-based ear drops can quickly relieve pain and inflammation of the middle ear cavity.
Like Tsiprolet, the medicine is not prescribed to pregnant women, nursing mothers, or children under 12 years of age. The cost of appointments is in one price category.
Contraindications
According to the official instructions, the drug Tsiprolet is contraindicated:
- pregnant women;
- nursing mothers;
- children and adolescents under 18 years of age;
- patients with individual sensitivity to constituent substances;
- intravenous administration of the drug to patients with pseudomembranous enterocolitis who have a deficiency of the cytosolic enzyme G6LID is contraindicated;
Patients with cerebral circulatory disorders, epilepsy, mental illness, liver or kidney failure require careful use of Tsiprolet. The dose for such patients should be significantly lower. If the drug is prescribed to patients to prevent the appearance of sand in the kidneys and urine, patients should drink large amounts of fluid daily. Urine should not have a high level of alkalization.
It is not advisable for elderly people to take Tsiprolet.
Side effects
The instructions indicate that taking this medication may cause the following side effects:
- headache and dizziness;
- insomnia;
- constant fatigue;
- increased intracranial pressure;
- noise in ears;
- hallucination;
- Gastrointestinal tract: pain in the abdomen, vomiting and nausea, bloating and diarrhea, cholestatic jaundice;
- tachycardia and hypotension;
- muscle, joint pain;
- skin rashes: hives and itching, redness of the skin.
conclusions
So is it possible to drink alcohol during treatment with Tsiprolet, are they compatible? Since a disulfiram-like reaction can cause complications that threaten the patient’s life, you should not drink alcohol during treatment with Tsiprolet. Drinking alcohol is allowed only when the drug is completely eliminated from the body. This time is 10 hours.
Reviews from doctors indicate that Tsiprolet, even when taken properly, impairs concentration so much that a person is prohibited from driving and operating machinery. In addition, side effects are possible, including nervous disorders, changes in liver function, and gastrointestinal tract.
Alcohol, being a poison for the body, can aggravate these disorders, as well as provoke severe poisoning due to a disulfiram-like reaction. When can you drink? You should abstain from alcohol until you recover and cancel Tsiprolet.
People who drank a little alcohol during treatment with Tsiprolet say that they experienced sharp stomach pains and allergic skin rashes. nausea. Most patients stopped playing with their health and gave up alcohol until they recovered.
Instructions for use
Method and dosage of tablets
Tsiprolet tablets are prescribed to adults and children at least 15 years of age. Taking the drug does not depend on food intake. It is well absorbed, but for the best effect, Tsiprolet tablets should be taken before meals, washed down with plenty of liquid. The daily dose is determined individually by the attending physician, taking into account the condition of the patient’s kidneys and liver. The usual interval between doses is 12 hours.
Dosage:
- Respiratory tract infections: 250mg-500mg/2 times/day.
- Acute pneumonia associated with streptococcus: 750 mg/2 times/day.
- Uncomplicated infection of the genitourinary system: 250 mg/2 times/day.
- Complicated infection of the genitourinary system, prostate: 500 mg/2 times/day.
- Infections of the musculoskeletal system and ENT infections: 500mg-75mg/2 times/day.
- Gynecology: 500 mg/2 times/day.
- Acute intestinal infections: 500 mg/2 times/day.
- Gastroenteritis: 250/2 times/day.
- Peritonitis, sepsis: 500mg-750mg/2 times/day.
Method and dosage of drops
Tsiprolet in drops, according to the instructions, is prescribed to adults and children over 12 years of age. The dosage of the drug is as follows: 1 drop – 2 drops / 1 time in 4 hours. Severe infections: 1 drop-2 drops/1 time per hour. If the condition improves, the number of doses of the drug is reduced to 1 time / every 4 hours. Treatment with drops lasts until complete recovery.
Method and dosage of solution
The instructions note that Tsiprolet in solution is administered intravenously by drip in doses that depend on the patient’s condition. The drug must be administered within 30 minutes - 60 minutes.
Dosage:
- Respiratory infection: 200 mg/2 times/day.
- Uncomplicated acute gonorrhea: 100 mg/2 times/day.
- Uncomplicated infection of the genitourinary system: 100 mg/2 times/day.
- Complicated infection of the genitourinary system: 200 mg/2 times/day.
- Other infections: 100 mg/2 times/day.
- Inflammatory processes of the genitourinary system and kidney infections have an average course of treatment of 1 week. The disease osteomyelitis requires the use of Tsiprolet for two months. Cystitis and acute uncomplicated gonorrhea require daily therapy. The treatment period for other infectious diseases is 2 weeks.
Severe forms of diseases require treatment with Tsinprolet in the form of a drip solution, then in tablet form.
During pregnancy and lactation
Tsiprolet is an antibiotic that is contraindicated in pregnant and breastfeeding women. Breastfeeding should be stopped while using the drug.
special instructions
The average course of use of Tsiprolet in tablets is 5-7 days. This period depends on the severity of the disease and on the result of bacteriological examination. If the patient has a problem with kidney function, the dose and intake of the medication is halved. After the symptoms of the disease become not obvious, the drug should be continued for another 3 days.
The average course of taking the medicine in the form of a solution for infusion is on average 7-14 days. After the symptoms of the disease become not obvious, the drug should be continued for another 3 days. The average course of taking Tsiprolet drops is 5-14 days, depending on the severity of the disease.
Tsiprolet or Augmentin - what to choose
Augmentin and Tsiprolet are effective for angina, but they belong to different pharmacological groups. For this reason, co-administration is unacceptable, as well as replacing one medication with another in the treatment protocol without medical permission. When prescribing a potent drug for tonsillitis, the doctor conducts a bacteriological culture to identify the resistance of the pathogen to antibiotics of the penicillin group, macrolides and cephalosporins. If the result is negative (means that the antibiotic is effective), Augmentin is prescribed along with Tsiprolet. When choosing between two medications, consider their positive and negative sides.
The advantages of Tsiprolet include:
- effectiveness against bacterial microorganisms resistant to penicillin antibiotics;
- minimal negative impact on the gastrointestinal tract;
- the use of Tsiprolet does not change the intestinal and vaginal microflora in women, does not cause dysbacteriosis, candidiasis and vaginosis;
- prolonged action of the drug (12 hours between doses);
- course duration is 5-7 days;
- low cost.
Cons of Tsiprolet:
- an extensive list of side effects;
- inadmissibility in the treatment of children under 15 years of age;
- Contraindicated for pregnant and lactating women.
In comparison with Tsiprolet, Augmentin is characterized by the following undeniable advantages:
- the synergy of the components (clavulanic acid and amoxicillin) helps quickly eliminate the provocateur of sore throat;
- the drug is approved for use by children from 3 months;
- with caution, but acceptable in the 2-3 trimester of pregnancy;
- the list of contraindications is much smaller.
Interaction with other drugs
- The use of Tsiprolet with the synthetic antiviral drug Didanosine helps to reduce the absorption of the former. Didanosine contains aluminum and magnesium salts, which prevent the formation of ciproflocsacin complexes.
- Together with the bronchodilator drug Theophylline, Tsiprolet can exceed the content of the former in the blood. As a result, the patient risks receiving the toxic effect of Theophylline.
- At the same time, taking Ciprolet with antacids, those drugs that contain zinc, iron, magnesium, reduces the possibility of absorption of ciprofloxacin.
Check out the price of Tsiprolet in 2020 and cheap analogues >>> The cost of the drug Tsiprolet in different pharmacies can vary significantly. This is due to the use of cheaper components in the drug and the pricing policy of the pharmacy chain. But the important thing is that the price difference between foreign and Russian analogues remains almost unchanged.
Source: www.medmoon.ru
