Xylometazoline overdose symptoms

Indications

Indications for use are:

• Acute rhinitis;
• Sinusitis;
• Sinusitis;
• Eustachite;
• Otitis media;
• Allergic rhinitis, hay fever;
• Preparation for surgical interventions in the nasal area.

Vasoconstrictor nasal drops without xylometazoline

Often patients with colds are concerned about the question, which nasal medications are best to use? Doctors have been arguing for many years about the need for various drugs, but experts agree on one issue.

It is best to treat a runny nose with drops that do not contain xylometazoline . It is quite difficult to choose a medication without this active ingredient, so we offer a list for you to study.

Adrianol

One of the most effective drops for rhinitis is Adrianol. The active component of this drug belongs to the sympathomimetic group, which affects the source of inflammation. Immediately after use, the patient notes the effect on the respiratory tract. It should be noted that there is no negative factor on beta-adrenergic receptors, which is especially important when treating young children.

Adrianol has a vasoconstrictor effect and also relieves swelling in the nasal mucosa. When applied to the nasal mucosa, only small arterioles narrow, which causes an immediate reduction in swelling. In addition, this effect of the drug allows you to reduce the amount of liquid or mucous secretion, restoring nasal breathing.

The effect of the drug begins two minutes after application and lasts for eight hours.

Adrianol can be used in case of mucous membrane and swelling in patients suffering from inflammation of the nose in case of rhinitis or pharyngitis. In addition, the medication is prescribed for sinusitis, sinusitis or hay fever.

Do not use this medication if you are particularly sensitive to the components of the drug, or if you have rhinitis without mucous discharge, which is also called dry runny nose.

Other contraindications to the drug include the presence of closed glaucoma.

Do not use the product if you have arrhythmia, heart problems, metabolic disorders, diabetes, or if you are using MAO inhibitors or other medications that may cause an increase in blood pressure.

Adrianol should be used as follows:

1. When treating adults, it is necessary to administer four drops five times a day.
2. For children, three drops should be administered three times a day.

In some cases, your doctor may change the dosage.

Salin

Another drug that does not contain xylometazoline is Salin. Its action is aimed at reducing swelling and restoring respiratory function. Salin has a pronounced anti-congestive effect and is considered a harmless drug for the treatment of children. In addition to the vasoconstrictor effect, the medication has an anti-inflammatory effect.

Salin should be used in case of prolonged rhinitis.
Its main effect is to improve nasal breathing with abundant secretion of mucous secretion.
By thinning thick mucus, the active substance of the drug removes secretions from the body. In addition, Salin moisturizes the mucous cavity and softens the formed crusts.

In addition to the described effect, Salin has an antiseptic effect.

The bactericidal effect allows the product to be used for rhinitis, inflammation of the paranasal sinuses and other inflammations in the upper respiratory tract.

In addition, doctors often prescribe this medication in cases of atrophic, infectious and allergic rhinitis. Salin is useful to use as a drug to maintain hygiene of the nasal mucosa and in the case of complex therapy for inflammation of the sinus region.

Salin is necessary for patients whose professional activities involve constant contact with dust, building materials, as well as in an office where the air conditioner is often running.

It is important to note that this drug has virtually no contraindications or identified side effects.

The product must be used as follows:

1. To treat children, one spray into each nostril three times a day is sufficient.
2. For therapy in adults, up to two injections at a time three times a day are prescribed.

Do not use the product in case of severe acidosis, as well as hypernatremia and extracellular hyperhydration.

Pinosol

For the treatment of rhinitis, a drug from the clinical-pharmacological group of anti-inflammatory action is suitable - Pinsol . A local drug for the treatment of rhinitis is prescribed in case of acute illness.

In addition to the anti-inflammatory effect, the medication has
an antimicrobial effect .
The plant origin of the drug allows the product to be used from the age of two. The medication relieves swelling and, thanks to its antiseptic effect, destroys the cause of inflammation, improving the patient’s overall well-being. Therefore, this remedy is effective in the following cases:

• coryza;
• chronic rhinitis;
• atrophic runny nose;
• acute inflammation in the nasal mucosa and nasopharyngeal cavity;
• dry mucous membrane;
• copious secretion of mucous secretion;
• in case of rehabilitation after surgery.

For treatment with Pinsol, you must adhere to the following dosages:

1. When treating children, it is enough to administer two drops of the drug.
2. For adults, four drops are usually prescribed.

The product must be used once a day. The dosage should not be violated, as side effects may occur. If dizziness, nausea, vomiting and other symptoms of overdose occur, call an ambulance.

Vibrocil

Vasoconstrictor medication for topical use without xylometazoline - Vibrocil .
This drug has an alpha-adrenomimetic effect, which causes vasoconstriction.

This effect reduces swelling, improves nasal breathing and restores the functions of the upper respiratory tract.

This medication will be useful for those who do not tolerate contact of medications with the mucous membrane.

Its effect reduces sensitivity and removes mucus from the nasal cavity. The medication reduces the effect of irritation of the cavity during rhinitis, as well as in the case of long-term treatment with antibiotics. In addition, Vibrocil is prescribed in case of long-term treatment with drops containing xylometazoline.

The effect of the drug begins two minutes after administration of the drug into the nasal cavity. In therapeutic concentrations, Vibrocil does not provoke the mucous membrane and improves nasal breathing. Therefore, doctors prescribe this drug in the following cases:

• sinusitis;
• hay fever;
• acute rhinitis;
• respiratory inflammation;
• allergic rhinitis;
• chronic rhinitis;
• eustachitis;
• with inflammation of the middle part of the ear with increased swelling of the mucous part in the nasopharynx cavity;
• when preparing the patient for surgery.

The product must be used as follows:

1. For the treatment of children under five, one spray is prescribed in each nostril up to three times a day.
2. When a child between five and eleven years of age has inflammation, it is necessary to administer two sprays into each nasal passage.
3. For the treatment of adults, three injections three times a day are sufficient.

Do not use the product more often than prescribed. Remember to administer the drug immediately before bedtime.

Contraindications

Contraindications are:

• Atrophic rhinitis;
• Simultaneous use or two weeks after tricyclic antidepressants and MAO inhibitors;
• Hypertonic disease;
• Tendency to nosebleeds;
• Closed-angle and open-angle glaucoma;
• Hypersensitivity;
• Severe atherosclerosis;
• Surgical interventions in the area of ​​the meninges;
• Thyrotoxicosis;
• Children's age for 0.05% up to 2 years.

Use with caution for cardiac ischemia, prostatic hyperplasia, pregnancy, diabetes and lactation.

The mechanism of action of Xylometazoline:

Additionally

Use in children. Contraindication: children under 2 years of age for using a 0.05% solution and under 6 years of age for a 0.1% solution.

Before use, it is necessary to clean the nasal passages. Should not be used for more than 7 days.

Typically, xylometazoline does not affect performance and does not make it difficult for vehicle drivers to work or control moving machinery.

In some cases, frequent and/or long-term use of the drug may lead to adverse reactions that impair the ability to drive a car or operate machinery.

Side effects

Side effects appear as:

• Dry nose;
• Bloody discharge when blowing your nose;
• Sneezing;
• Paresthesia;
• Irritation, burning in the nose;
• Edema of the mucous membrane;
• Increased blood pressure;
• Tachycardia;
• Arrhythmias;
• Headache;
• Vomiting;
• Insomnia;
• Feelings of heartbeat;
• Visual impairment;
• Vasomotor rhinitis;
• Depression.

Overdose

Spray

apply intranasally.

Adults and children over 6 years old: 1 injection of 0.1% xylometazoline solution into each nasal passage 2-3 times a day.

Children aged 2 to 6 years use 0.05% xylometazoline solution, 1 injection into each nasal passage 1-2 times a day.

The drug should not be used more than 3 times a day. The course of treatment for rhinitis should not exceed 5-7 days.

Symptoms of drug overdose

: decreased body temperature, bradycardia, increased blood pressure.

Treatment: symptomatic.

All forms of the drug are used intranasally.

Xylometazoline nasal drops 0.1% are used in adults, 1-2 drops at each turn three times a day.

The 0.1% spray is used in adults with 1 pump (corresponding to 0.1 mg) per stroke. The applicator is inserted, maintaining the vertical position of the bottle, and injected three times a day after 8-10 hours.

Gel 0.1% is used by adults, 2-3 drops of gel 3 times a day.

Considering the possibility of systemic adsorption and the occurrence of adverse reactions, the instructions for use of Xylometazoline must be strictly followed. Use the drug in any form of release for no more than 3-5 days. Should not be used for a long time or for chronic rhinitis. If crusts appear in the nose, it is better to use the drug in gel form. If a dose is missed, the next dose will not be doubled.

Manifested by symptoms: dilated pupils, cyanosis, nausea, vomiting, fever, tachycardia, arrhythmias, cardiac arrest, respiratory failure, hypertension, pulmonary edema, mental disorders. Drowsiness, bradycardia, apnea and coma indicate suppression of central nervous system function.

Treatment: gastric lavage, sorbents, artificial respiration, drugs to lower blood pressure, antipyretics and anticonvulsants.

Reviews about the drug

The drug received quite a lot of positive reviews, which reflected the effectiveness of the product. It helped get rid of nasal congestion, swelling of the mucous membrane, and also reduced the activity of secretion production.

The drug should be used strictly according to the instructions, as according to the doctor, it can be addictive and cause side effects.

Xylometazoline for children

For acute rhinitis in children, it is not advisable to use short-acting vasoconstrictors: Naphazoline, Tetrizoline, Ephedrine, since after their use there is recurrent swelling of the nasal mucosa. It is preferable to use long-acting drugs: Xylometazoline (Dlyanos, Otrivin), Oxymetazoline (Nazivin), Epinephrine (Vibrocil), which allows you to reduce the frequency of use.

Remember that the risk group for poisoning with imidazoline (Xylometazoline) drugs are children under 2 years of age. This drug is not recommended for use in newborns, infants, or children under 2 years of age. In rare cases, if there is no alternative, 0.05% drops are prescribed to children under 2 years of age.

For children over 2 years of age, only a 0.05% concentration of this drug is used, and it is necessary to strictly dose and observe the frequency of use.

From 2 to 6 years, 0.05% drops, 1 to 2 drops at each turn, twice a day, if necessary, use up to 3 times a day is acceptable. From 6 to 12 years, you can use 0.05% drops and 0.05% spray 2-3 drops or one injection per stroke, but no more than 3 times a day.

Children over 7 years old are prescribed 0.05% gel - placed 3-4 times a day deep into each stroke.

From 12 years old, 0.1% drops and spray are used.

It is necessary to take into account that frequent and long-term (more than 5 days, in some authors - more than 3 days) use of this drug can cause a pronounced decrease in local blood flow, as a result of which inadequate blood supply to the mucosa develops, up to its atrophy in the future. In this regard, you should not use the drug in any form of release more than 3 times a day or for more than 3-5 days.

If there is a need to use nasal drops at an earlier age, then Vibrocil is approved for use in children from infancy. In infants, Nazivin 0.01% is also used, from the age of 1 year - Nazivin 0.025%.

Analogs

Analogues of the drug are:

• Otrivin;
• For nose;
• Sanorin-xylo;
• Rinomaris;
• Rhinonorm;
• Tizin;
• Eucazoline;
• Xylene;
• Rhinorus.

Cheap

Cheap analogues of the drug are Oxymetazoline, Rinostop, Galazolin, Rinotaiss.

Analogues of the drug

The effect of Xylometazoline on the fetus during pregnancy

The main active ingredient is xylometazoline hydrochloride. It is he who produces the vasoconstrictor effect. It develops due to its influence on alpha adrenergic receptors located in the walls of blood vessels. Irritation of the receptors leads to a condition that is similar to the action of adrenaline - the blood vessels narrow. Next, the following mechanisms are implemented:

• liquid cannot sweat from vessels into tissues;
• swelling of the mucous membrane decreases;
• Reducing the flow of blood to the cells of the nasal membrane inhibits the secretion of mucus.

A feature of Xylometazoline is its low ability to penetrate the bloodstream. Its plasma concentrations are so low that they cannot be detected using modern diagnostic methods.

But whether it is possible for pregnant women to drip Xylometazoline into the nose, the doctor must decide. Despite its low absorption capacity, large doses are thought to have adverse effects on the fetus.

The reaction of blood vessels to alpha adrenergic agonists is the same, regardless of where they are located. Spasm can occur in the vessels of the placenta, which can lead to acute fetal hypoxia. Reduced blood flow leads to oxygen starvation, which can lead to damage to vital organs, and in severe cases, intrauterine fetal death.

But the peculiarities of using the drug are such that it is instilled or sprayed locally; most women do this only a few times a day. Therefore, such severe pregnancy complications are hypothetical.

Read about oxymetazoline during pregnancy.