The antibiotic Zinnat has a bactericidal effect on gram-positive and gram-negative cocci and bacilli, destroying their flora and destroying their basic functions. All this is extremely important in the treatment of viral infections, including sinusitis, when inflammation of the paranasal sinuses is caused by the proliferation of bacteria in the human body. It is no secret that sinusitis is treated in different ways, and in each case complex therapy is required, but antibacterial agents are in first place among the most effective drugs. They allow you to get rid of infectious agents, destroy the negative effects of microbes and bacteria, restore damaged tissues and strengthen the body's protective functions. Zinnat for sinusitis is an effective broad-spectrum remedy with relatively low toxicity, which makes it possible to count on positive results in the treatment of an unpleasant illness.
Zinnat is a strong antibiotic used to treat sinusitis.
What should you know about sinusitis?
Today, a lot is known about sinusitis, but this still does not protect people from contracting the infection. The disease can develop as a result of an untreated runny nose, trauma to the mucous membrane, proliferation of dangerous bacteria and viruses in the nasopharynx, hypothermia, etc.
As a result of the spread of infection, inflammation begins, which cannot be stopped only with the help of nasal drops and traditional methods for treating colds: tea with honey, tea with lemon, medicinal herbs, etc. As a rule, a person is faced with numerous unpleasant symptoms:
- Painful sensations in the nose and paranasal area. The pain is pronounced in the evening, and by morning it gradually subsides.
- Nasal congestion, causing difficulty breathing.
- Severe runny nose with profuse discharge.
- An increase in body temperature, although this is not a necessary manifestation of sinusitis.
With sinusitis, there is nasal congestion, difficulty breathing, and sometimes body temperature rises
. With such symptoms, you should not remain indifferent, because if you delay treatment of the disease, it will lead to the most unpredictable and undesirable consequences. It is recommended to urgently seek medical help; the doctor must conduct an examination and establish an accurate diagnosis. Only after this can any treatment begin, and then it must be agreed with your doctor.
How the drug works
Cefuroxime exhibits a bactericidal effect by inhibiting the synthesis of bacterial cell walls by binding to target proteins.
The drug Zinnat is effective against most anaerobic, gram-negative and gram-positive microorganisms. Due to resistance to the effects of beta-lactamases, diseases caused by amoxicillin-resistant and ampicillin-resistant strains of microbes can be treated with this antibiotic.
After oral administration, cefuroxime is quickly absorbed from the digestive system. At the same time, the rate of absorption improves when taken simultaneously with food . About half of the drug that enters the body binds to blood proteins. The maximum content of cefuroxime in plasma is observed 2-3 hours after administration. This drug is not metabolized and is excreted unchanged from the body along with urine.
Cefuroxime has the ability to penetrate the placental barrier and into breast milk.
What is prescribed for sinusitis?
This is a broad question because there is no single drug that is prescribed to treat the disease. In order to get rid of a serious illness, you will need to undergo complex therapy, consisting of the use of a variety of medications and unique treatment methods.
A variety of methods are used to treat sinusitis.
The following medications are considered the most effective:
- Nasal rinsing solutions made from sea water and table salt.
- Nasal drops: herbal, homeopathic, antiseptic, antibacterial, etc.
- Antibiotics designed to suppress a variety of dangerous bacteria and microbes.
- Antiseptics, the task of which is to facilitate the outflow of secretions from the nasal sinuses.
- Auxiliary methods: physiotherapy, mucolytic agents, acupressure, etc.
It is not recommended to start self-treatment, because you may not know the main cause of the disease and the characteristics of your body. Almost every drug has contraindications, which should also be taken into account before starting to use a particular drug.
You can even perform acupressure as an auxiliary treatment.
Release form, composition and packaging
Zinnat is produced in several pharmaceutical forms:
- In the form of tablets, film-coated on top, white or almost white, biconvex, oval, “GXES5” is engraved on one side, and a white or almost white core is visible on the transverse section.
Active ingredients: 1 tablet contains 150.36 mg of cefuroxime axetil, which is similar to the 125 mg content of cefuroxime.
Additional substances: sodium lauryl sulfate, croscarmellose sodium, microcrystalline cellulose, colloidal silicon dioxide, hydrogenated vegetable oil.
Film shell composition: propyl parahydroxybenzoate, methyl parahydroxybenzoate, propylene glycol, hypromellose, opaspray dye (sodium benzoate 0.1%, titanium dioxide 36%, hypromellose 3%).
There are 2.1 blisters in a cardboard package, each containing 5 tablets.
There are 2.1 blisters in a cardboard package, each containing 10 tablets.
- In the form of tablets, film-coated on top, white or almost white, biconvex, oval, “GXES7” is engraved on one side, and a white or almost white core is visible on the transverse section.
Active ingredients: 1 tablet contains 300.72 mg of cefuroxime axetil, which is the same as 250 mg of cefuroxime.
Additional substances: sodium lauryl sulfate, croscarmellose sodium, microcrystalline cellulose, colloidal silicon dioxide, hydrogenated vegetable oil.
Film shell composition: propyl parahydroxybenzoate, methyl parahydroxybenzoate, propylene glycol, hypromellose, opaspray dye (sodium benzoate 0.1%, titanium dioxide 36%, hypromellose 3%).
There are 2.1 blisters in a cardboard package, each containing 5 tablets.
There are 2.1 blisters in a cardboard package, each containing 10 tablets.
- In the form of granules, as the basis for preparing a suspension for oral administration, they have the form of grains of irregular shape, white or almost white, the size of which varies, but not more than 3 mm; when diluted, a suspension is formed from white to light yellow, with a characteristic fruity smell.
Active ingredients: 5 ml of granules contain 150 mg of cefuroxime axetil, which is similar to the 125 mg content of cefuroxime.
Additional substances: acesulfame potassium, tutti-frutti flavor, sucrose, stearic acid, povidone K30, aspartame, xanthan gum.
The cardboard packaging contains 1 dark glass bottle with a volume of 1.25 g, a measuring cup and a dosing spoon are included.
- In powder form, as a basis for preparing a solution for intravenous and intramuscular administration.
Antibiotics: their effectiveness, benefits and effects
Antibiotics are prescribed for sinusitis when the human body is unable to cope with a viral infection on its own over a long period of time. In this case, the inflammatory process continues actively, which entails the risk of severe complications. Antimicrobial therapy is designed to solve this problem, since its task is to destroy infectious agents, prevent their further reproduction and penetration into other organs and systems of the body.
There are many types of antibacterial drugs that are used for inflammation of the maxillary sinuses: these are macrolides, cephalosporins, fluoroquinolones, etc. Zinnat, which is also often prescribed by otolaryngologists, belongs to the second generation cephalosporin antibiotics. As you know, this is one of the most common groups of antibiotics that have a beneficial effect in getting rid of sinusitis. The drug is incompatible with the consumption of alcoholic beverages and can irritate the mucous membranes quite strongly, but nevertheless it is considered a very effective remedy for preventing inflammation in the paranasal sinuses.
Most often, for sinusitis, antibiotics are prescribed, which destroy the causative agents of infection.
Indications for use
The instructions recommend prescribing Zinnat for:
- infections of the upper and lower respiratory tract: infection of the chest organs after surgery, lung abscess (accumulation of pus in the lung tissue), bacterial pneumonia, infected bronchiecstasis (dilation of part of the bronchus, which is irreversible), acute or chronic bronchitis;
- ENT infections: tonsillitis (inflammation of the tonsils), pharyngitis (inflammation of the pharynx), acute otitis media (inflammation of the ear), sinusitis (inflammation of the paranasal sinuses);
- infections of the genitourinary system: acute or chronic pyelonephritis (inflammation of the kidneys), urethritis (inflammation of the wall of the urethra), cystitis (inflammation of the bladder), asymptomatic bacteriuria (colonization of the urinary tract by bacteria), gonorrhea (infectious disease caused by gonococcus);
- diseases of the skin and soft tissues: erysipeloid (infectious skin lesions), phlegmon (purulent inflammation of the tissue), furunculosis (formation of multiple boils), impetigo (formation of pustules caused by staphylococcus and streptococci), wound infection (reproduction of pathogenic microorganisms in the wound), pyoderma (diseases skin caused by pyogenic bacteria), erysipelas (inflammation of the skin caused by streptococcus);
- diseases of bones and joints: septic arthritis (penetration of microorganisms into the joint cavity), osteomyelitis (purulent inflammation of the bone), etc.;
- infections of the pelvic organs: cervicitis (inflammation of the cervix), adnexitis (inflammation of the uterine appendages), endometritis (inflammation of the uterine mucosa);
- sepsis (an infectious disease caused by toxins, single-celled fungi or bacteria entering the blood);
- meningitis (inflammation of the membranes of the spinal cord or brain);
- Lyme disease (bacteria are transmitted to humans through the bite of an infected tick);
- prevention of complications during operations on the abdominal cavity, chest, joints, and pelvis.
Zinnat, reviews confirm, is effective against the above diseases if they are caused by bacteria sensitive to this drug.
Zinnat for sinusitis
The antibiotic Zinnat for sinusitis is known for its bactericidal properties. In addition, the drug has low toxicity and has a small number of contraindications and side effects. The medicine is prescribed not only for sinusitis, but also in the presence of some other diseases:
- Sore throat, otitis media, tonsillitis and other diseases accompanied by inflammatory processes.
- Cystitis, urethritis, gonorrhea and other diseases of the genitourinary system.
- Meningitis, which, by the way, can develop as a complication of incompletely cured sinusitis.
- Skin diseases.
Zinnat is also prescribed to children for sinusitis and some other diseases.
The main active ingredients of the antibiotic destroy the structure of bacteria, destroy microbes that cause infection and remove them from the body. Thus, you can count on complete relief from the disease in the shortest possible time. In addition, the medicine helps to quickly restore the functions of the respiratory system.
The drug is even prescribed for the treatment of sinusitis in children, but appropriate permission from an otolaryngologist is required. This is the only way you can count on the therapeutic course being absolutely safe and extremely effective for your health.
Antibiotic for ear inflammation (otitis media) in children is very effective
Antibiotic "Zinnat" (Cefuroxime) 125 mg/5 ml.
Until the age of three, our son was practically not sick, but as soon as we started kindergarten, problems immediately began, and for the first three weeks he held up well, but this is also because he was only up until lunchtime (that is, he did not sleep). But as soon as I stayed to sleep for lunch - ALL: incomprehensible snot that does not flow, and which is practically not visible, you can only hear that they are somewhere far away, we have never had this before!
I tried to rinse my nose more and more often so that at least the snot would come out and liquefy, but at one point I heard: “Mom, my ear hurts...” and after that the baby was hysterical for an hour because of the pain, that we couldn’t did, even though in all the confusion they thought of giving Nurofen! The baby fell asleep, woke up - everything is fine! But after a while - again!
It was Sunday, so we were at a loss where to turn, we were advised to go to the ENT center, but when we got there, they looked at us with surprised eyes: “But there is no doctor on duty here on the weekend,” although many say that there should be, since there is a day hospital there... Then a neighbor who works as an ambulance told us that we need to go to the regional adult hospital - they should still help!
We went there, found an instrument of the right size to examine the ear, and it turned out that the ear was inflamed. They prescribed us drops in the ear and nose for 7 days, but already on the 4th day the baby complained again, but at night, so we went to the ENT center, where they said that in this case we couldn’t do without antibiotics!
They prescribed us Zinnat for 7 days. This is probably the most popular antibiotic for ear infections.
Yes, he did a great job in curing our sore ear, but the runny nose still remained, what kind of “bacillus” were these, that the antibiotic didn’t take them away.
It turns out that what we started treatment with – a runny nose – is what we ended up with – a runny nose.
Zinnat is sold as a bottle with granules for preparing a suspension, it is very convenient that it comes with a cap on which there is a mark - how much water you need to add to get a suspension, but only after 6-7 days there is little suspension left, and it is very thick , so you have to drip a little more water.
You need to remember that the dose depends on the child’s weight, and when taking antibiotics, you must definitely take lactobacilli so as not to “get” something like stomatitis.
Ear inflammation is a very common problem, it turns out now, but this is also because we are all often told that the nose needs to be washed, but that this must be done carefully, since in children the Eustachian tube is very close, and snot can be driven into the ear - For some reason, I had never heard about this before from any pediatrician who told me about rinsing the nose. Although in our case it is unknown what exactly caused the inflammation, since thick snot can very often cause complications in the ear!
Use of the drug
The course of treatment is selected by the doctor individually for each patient; this is influenced by factors such as the cause of sinusitis, its symptoms, the course and severity of the disease. On average, the therapeutic course lasts 7 days, but can be extended if necessary.
Zinnat comes in a variety of forms
As can be seen in the reviews of Zinnat for sinusitis, the drug is most often prescribed in the following average doses:
- 250 mg 2 times a day for adults and 50-60 mg 2 times a day for children.
- 500 mg in case of complications in adults or acute inflammatory process in case of respiratory tract infections, 80-100 mg in children with the development of serious complications.
- The dose is increased for severe infections.
It is strictly forbidden to independently regulate the dosage, as this can lead to unpredictable consequences for human health. Be sure to consult your doctor; perhaps in your particular case it is contraindicated to take this antibiotic or there are objective reasons to reduce the dosage.
Contraindications and possible side effects
Zinnat cannot be prescribed to every patient. It is contraindicated:
- with hypersensitivity to cephalosporins, carbapenems and penicillins,
- up to three months (for any form of medication),
- up to three years (for taking tablets).
The drug should be used with caution in the presence of renal failure and gastrointestinal diseases.
The medicine is usually well tolerated, but sometimes causes reversible side effects, which in children can occur in the form of:
- dyspepsia (abdominal pain, diarrhea, nausea, vomiting),
- an increase in the number of eosinophils, a decrease in the number of leukocytes and platelets, in rare cases there is a decrease in the number of red blood cells, leading to hemolytic anemia,
- skin allergic reactions,
- dizziness, migraine, seizures,
- hepatitis A.
Zinnat for children
Zinnat is also prescribed for sinusitis in children, although we should not forget that it is a potent antibiotic. Initially, you should make an appointment with an otolaryngologist who will examine your child. When a diagnosis of sinusitis is made, the specialist will prescribe an appropriate course of treatment, which should be strictly adhered to for further recovery.
Before using Zinnat, you should consult your doctor.
For children, the drug is prescribed depending on their age, weight and course of the disease. Here are the average dosages:
- Child from 3 to 6 months – 40-50 mg of medication 2 times a day.
- Children from 6 months to 2 years – 60-110 mg, if the child weighs 6-14 kg.
- Children from 2 to 12 years old – 120 mg 2 times a day, the child’s weight should not exceed 25 kg.
- Adolescents over 12 years old - 250-300 mg twice a day.
On the Internet you can see numerous reviews about Zinnat for sinusitis in children, which make it possible to draw the following conclusions: the drug is really useful for this disease, it successfully fights various types of viral infections, preventing the proliferation of bacteria inside the body. At the same time, you should be careful and consult a doctor at the slightest side effects, because antibiotics can also have a negative effect on human health, especially for young children.
At the first symptoms of sinusitis, you must be examined by an otolaryngologist.
Instructions for use of zinnat
Pharmacology
Cefuroxime axetil is a precursor to cefuroxime, which is a second generation cephalosporin antibiotic. Cefuroxime is active against a wide range of pathogens, including strains that produce β-lactamases. Cefuroxime is resistant to bacterial β-lactamases and is therefore effective against ampicillin-resistant or amoxicillin-resistant strains.
The bactericidal effect of cefuroxime is associated with the suppression of bacterial cell wall synthesis as a result of binding to the main target proteins.
In vitro, cefuroxime is active against the following microorganisms: gram-negative aerobes - Haemophilus influenzae (including ampicillin-resistant strains), Haemophilus parainfluenzae, Moraxella catarrhalis, Neisseria gonorrhoeae (including strains that produce and do not produce penicillinase), Escherichia coli, Klebsiella spp., Proteus mirabilis , Providencia spp., Providencia rettgeri; gram-positive aerobes - Staphylococcus aureus (including penicillinase-producing strains, but excluding methicillin-resistant strains), Staphylococcus epidermidis (including penicillinase-producing strains, but excluding methicillin-resistant strains), Streptococcus pyogenes and other beta-hemolytic streptococci, Streptococcus pneumoniae, Streptococcus group B (Streptococcus agalactiae); anaerobes - gram-positive and gram-negative cocci (including Peptococcus spp. and Peptostreptococcus spp.), gram-positive rods (including Clostridium spp., except Clostridium difficile, Propionibacterium spp.), gram-negative rods (including Bacteroides spp. and Fusobacterium spp.), gram-negative spirochetes ( Borrelia burgdorferi).
The following microorganisms are not sensitive to cefuroxime: Clostridium difficile, Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus, Listeria monocytogenes, methicillin-resistant strains of Staphylococcus aureus and Staphylococcus epidermidis, Legionella spp., Enterococcus faecalis, Morganella morganii, Proteus vulgaris, Enterobacter spp. , Citrobacter spp., Serratia spp., Bacteroides fragilis.
Pharmacokinetics
After oral administration, cefuroxime axetil is slowly absorbed from the gastrointestinal tract and rapidly hydrolyzed in the intestinal mucosa and blood to release cefuroxime. Cefuroxime axetil is optimally absorbed when taken immediately after meals.
After taking tablets, Cmax of cefuroxime (2.9 mg/l for a dose of 125 mg and 4.4 mg/l for a dose of 250 mg) is observed after approximately 2.4 hours when taking the drug after meals.
After taking the suspension, Cmax of cefuroxime (2-3 mg/l for a dose of 125 mg and 4-6 mg/l for a dose of 250 mg) are observed approximately 2-3 hours after taking the drug after meals.
The binding of cefuroxime to plasma proteins is 33-50%.
Cefuroxime crosses the blood-brain barrier, crosses the placenta and is excreted in breast milk.
Cefuroxime is not metabolized in the body.
Excreted by glomerular filtration and tubular secretion. Serum levels of cefuroxime decrease with dialysis.
Release form
White or almost white, oval, biconvex, film-coated tablets, with “GXES5” engraved on one side; on a cross section, the core is white or almost white.
| 1 tab. | |
| cefuroxime axetil | 150.36 mg, |
| which corresponds to the content of cefuroxime | 125 mg |
Excipients: microcrystalline cellulose - 47.51 mg, croscarmellose sodium - 20 mg, sodium lauryl sulfate - 2.25 mg, hydrogenated vegetable oil - 4.25 mg, colloidal silicon dioxide - 0.63 mg.
Film shell composition: hypromellose - 5.55 mg, propylene glycol - 0.33 mg, methyl parahydroxybenzoate - 0.06 mg, propyl parahydroxybenzoate - 0.04 mg, opaspray dye - 1.52 mg (hypromellose 3%, titanium dioxide 36%, sodium benzoate 0.1%).
5 pieces. - blisters (1) - cardboard packs. 5 pieces. - blisters (2) - cardboard packs. 10 pieces. - blisters (1) - cardboard packs. 10 pieces. - blisters (2) - cardboard packs.
Dosage
The standard course of therapy is 7 days (can vary from 5 to 10 days). For optimal absorption, the drug should be taken after meals.
| Indications | Dose (tablets and oral suspension) |
| Most infections | 250 mg 2 times/day |
| Urinary tract infections | 125 mg 2 times/day |
| Mild to moderate lower respiratory tract infections, such as bronchitis | 250 mg 2 times/day |
| More severe lower respiratory tract infections or if pneumonia is suspected | 500 mg 2 times/day |
| Pyelonephritis | 250 mg 2 times/day |
| Uncomplicated gonorrhea | 1 g once |
| Borreliosis (Lyme disease) in adults and children over 12 years of age | 500 mg 2 times/day for 20 days |
| Most infections | 125 mg (1 tablet of 125 mg) 2 times/day. Maximum daily dose - 250 mg |
| Otitis media or more severe infections | 250 mg (1 tablet of 250 mg or 2 tablets of 125 mg) 2 times a day. Maximum daily dose - 500 mg |
Oral suspension
The drug Zinnat ® in the form of an oral suspension is recommended for use in children from 3 months. There is no experience with the use of Zinnat ® in children under 3 months of age.
If a fixed dose is preferred, then for most infections it is recommended to take 125 mg 2 times a day. Children aged 2 years and older with otitis media or more severe infections are prescribed 250 mg 2 times a day; the maximum daily dose is 500 mg.
When treating infants and children, it may be necessary to calculate the dose depending on body weight and age. For most infections, the dose for infants and children aged 3 months to 12 years is 10 mg/kg 2 times a day, but not more than 250 mg/day. For otitis media and more severe infections, the recommended dose is 15 mg/kg 2 times a day, but not more than 500 mg/day.
The following tables show doses depending on the age and body weight of the child for dosing the Zinnat ® 125 mg/5 ml suspension in 5 ml measuring spoons supplied with the package.
Dose of 10 mg/kg body weight prescribed for most infections
| Age | Body Weight (kg) (approx.) | Single dose (mg) when taken 2 times a day | Number of scoops (5 ml) per dose |
| 3-6 months | 4-6 | 40-60 | 1/2 |
| 6 months-2 years | 6-12 | 60-120 | 1/2-1 |
| 2-12 years | from 12 and over 20 | 125 | 1 |
Dose of 15 mg/kg body weight prescribed for otitis media and more severe infections
| Age | Body Weight(kg)(approx.) | Single dose (mg) based on body weight | Number of scoops (5 ml) per dose |
| 3-6 months | 4-6 | 60-90 | 1/2 |
| 6 months-2 years | 6-12 | 90-180 | 1-1.5 |
| 2-12 years | from 12 and over 20 | 180-250 | 1.5-2 |
Cefuroxime is also available in the form of a sodium salt (Zinacef®) for parenteral administration, which allows the same antibiotic to be prescribed sequentially when switching from parenteral to oral therapy is necessary. The drug Zinnat ® is effective after parenteral use of the drug Zinacef ® for the treatment of pneumonia and exacerbation of chronic bronchitis.
The duration of parenteral and oral courses of treatment is determined by the severity of the infection and the clinical picture.
The drug Zinacef ® (cefuroxime in the form of sodium salt) at a dose of 1.5 g 2-3 times a day (IV or IM) for 48-72 hours, then the drug Zinnat ® (cefuroxime axetil) orally at a dose of 500 mg 2 times/day for 7-10 days.
Exacerbation of chronic bronchitis
The drug Zinacef ® (cefuroxime in the form of sodium salt) at a dose of 750 mg 2-3 times a day (IV or IM) for 48-72 hours, then a course of treatment with Zinnat ® (cefuroxime axetil) orally at a dose 500 mg 2 times/day for 5-10 days.
Overdose
Symptoms: an overdose of cephalosporins can cause increased excitability of the brain with the development of seizures.
Treatment: carry out symptomatic therapy. Serum concentrations of cefuroxime are reduced during hemodialysis and peritoneal dialysis.
Interaction
Drugs that reduce gastric acidity may reduce the bioavailability of cefuroxime when compared with that observed after taking the drug on an empty stomach, and also neutralize the effect of increased absorption of the drug after meals.
Like other antibiotics, the drug Zinnat ® can affect the intestinal microflora, which leads to a decrease in the reabsorption of estrogens and, as a consequence, to a decrease in the effectiveness of oral hormonal combined contraceptives.
When performing a ferrocyanide test, a false negative result may be observed, therefore, it is recommended to use glucose oxidase or hexokinase methods to determine blood and/or plasma glucose levels.
The drug Zinnat ® does not affect the quantitative determination of creatinine by the alkali picrate method.
Concomitant use with loop diuretics slows down tubular secretion, reduces renal clearance, increases plasma concentrations and increases T1/2 of cefuroxime.
Coadministration of cefuroxime and probenecid results in an increase in AUC by 50%.
When taken simultaneously with aminoglycosides and diuretics, the risk of nephrotoxic effects increases.
Side effects
The adverse events presented below are listed depending on the anatomical and physiological classification and frequency of occurrence. The frequency of occurrence is defined as follows: very often (≥1/10), often (≥1/100 and ®) for parenteral administration. As part of stepwise therapy, it is recommended to switch from the parenteral form to the oral form of cefuroxime.
Stepped therapy is indicated in the treatment of pneumonia and exacerbation of chronic bronchitis.
Contraindications
- phenylketonuria (for oral suspension);
- children up to 3 months (for oral suspension);
- for tablets - children under 3 years of age (for children from 3 months to 3 years, the drug Zinnat ® should be used in the form of a suspension);
- hypersensitivity to cephalosporin antibiotics.
Caution should be exercised when prescribing to patients with impaired renal function; diseases of the gastrointestinal tract (including a history, as well as ulcerative colitis); pregnant women, during lactation.
Features of application
Use during pregnancy and breastfeeding
The drug Zinnat ® should be used if the expected benefit to the mother outweighs the potential risk to the child.
There is no experimental evidence of embryopathic or teratogenic effects of cefuroxime axetil, but as with other drugs, caution must be exercised when prescribing it in early pregnancy.
Caution must be exercised when prescribing it to nursing mothers, since the drug is detected in breast milk.
Use for renal impairment
Use in children
Contraindicated in children under 3 months of age (for oral suspension); for tablets - children under 3 years of age (for children from 3 months to 3 years, the drug Zinnat ® should be used in the form of a suspension).
special instructions
Caution should be exercised when prescribing the drug to patients with a history of an allergic reaction to beta-lactam antibiotics.
During treatment, it is necessary to monitor renal function, especially in patients receiving the drug in high doses.
During the period of taking the drug Zinnat ®, a false positive urine reaction to glucose is possible.
As with other antibiotics, long-term use of Zinnat ® can lead to overgrowth of Candida fungi. Long-term use may cause the growth of other resistant microorganisms (Enterococcus and Clostridium difficile), which may require discontinuation of treatment.
Pseudomembranous colitis has been observed with the use of broad-spectrum antibiotics, and the differential diagnosis of pseudomembranous colitis should be considered in patients with severe diarrhea that occurs during or after a course of antibiotic treatment.
The Jarisch-Herxheimer reaction was observed in borreliosis (Lyme disease) when taking the drug Zinnat ® and is due to the bactericidal activity of the drug against the causative agent of the disease, the spirochete Borrelia burgdorferi. Patients should be informed that these symptoms are a typical consequence of antibiotic use for this disease.
If the clinical effect is not achieved within 72 hours from the start of treatment, the parenteral course of therapy should be continued.
Before starting step therapy, you should consult available references regarding cefuroxime sodium salt (Zinacef®).
Zinnat ® tablets should not be broken or crushed. Therefore, this dosage form is not used to treat patients with swallowing difficulties, incl. small children who cannot swallow a whole tablet.
The sucrose content in the Zinnat ® suspension should be taken into account when treating patients with diabetes mellitus.
5 ml of prepared Zinnat ® suspension contains 0.25 bread units (XE).
Impact on the ability to drive vehicles and operate machinery
Since cefuroxime axetil may cause dizziness, patients should be warned to take precautions when driving or operating moving machinery.
source
