Hydrocortisone price in Tomsk from 28 rubles, buy Hydrocortisone, reviews and instructions for use

What it is?

The “Hydrocortisone” suspension refers to glucocorticosteroids; it is a hormone that is included in drugs with antitoxic, antiallergic, and decongestant effects.

The medicine is available in several forms:

1. Eye ointment.
2. Emulsion for intravenous and intramuscular administration.
3. Nasal, eye, ear drops.
4. Cream and ointment for external use.
5. Pills.
6. Suspension for intra-articular administration.
7. Injections in the form of lyophilisate.

We will talk about the Hydrocortisone suspension.

Contraindications

Hypersensitivity to the components of the drug, post-vaccination period, bacterial, viral and fungal skin diseases (pyoderma, mycosis), skin tuberculosis, violation of the integrity of the skin (ulcers, wounds), syphilitic skin lesions, skin tumors, children's age (up to 2 years, with itching in the anal area - up to 12 years).

Hydrocortisone in the form of an ointment should not be used if you are intolerant of its active substance or other components.

Skin treatment with 1% medicine is not carried out if:

• Ulcerative lesions.
• Open wounds.
• Bacterial infections
• Syphilitic or tuberculous lesions.
• Viral skin infections.
• Fungus on the skin.
• Skin tumors.
• Perioral dermatitis.
• Acne vulgaris.
• Rosacea.

The use of 0.5% medication in the eyes is contraindicated in:

• Purulent eye infections.
• Damage to the organ of vision by viruses, tuberculosis or fungus.
• Glaucoma.
• Vaccinations.
• Trachome.
• Damage to the cornea.

The use of 0.5% medication in the eyes is contraindicated in:

• Purulent eye infections.
• Damage to the organ of vision by viruses, tuberculosis or fungus.
• Glaucoma.
• Vaccinations.
• Trachome.
• Damage to the cornea.

pharmachologic effect

Hydrocortisone suspension is a natural glucocorticosteroid. They penetrate the molecular structure into the cell and bind to steroid receptors.

The use of the drug achieves the following effects:

1. Suppression of the main mediators of the inflammatory process.
2. Slowing down the formation of connective and phlegm tissue, the rate of scarring processes slows down.
3. Reduced production of bradykin, histamine, serotonin and synthesis of prostaglandids.

Emulsion "Hydrocortisone" has the following medicinal properties:

1. Antishock and anabolic. The permeability of the vascular walls narrows, liver enzymes are activated, and vascular tone is regulated.
2. Anti-inflammatory. The release of phospholipase into the tissue, as well as its production, is suppressed.
3. Antiallergic. Emulsion "Hydrocortisone" reduces the release of histamine and reduces the susceptibility of cells to allergens. The drug is used for severe forms of the disease.
4. Immunosuppressive. The medicine suppresses the pathological activity of the immune system when it begins to fight its own cells.

The suspension is prescribed during organ transplantation and autoimmune pathology.

The medication is able to reduce cell infiltration, and it also reduces the release of exudate. Mineralocorticoid activity is known and is achieved through the ability to reduce sodium excretion from the body. At the same time, the instructions for use of the Hydrocortisone suspension say that the drug stimulates the release of potassium. The therapeutic effect develops slowly, but lasts a long time. The suspension can be administered intra-articularly, intravenously or intramuscularly.

Operating principle

Hydrocortisone has a pronounced anti-inflammatory effect. This substance is classified as a synthetic glucocorticoid. It activates steroid receptors, affects the formation of prostaglandins, stabilizes cell membranes, participates in the metabolism of arachidonic acid and inhibits the release of compounds responsible for the inflammatory response. Under the influence of Hydrocortisone, the release of interferons and interleukins, which support inflammation, is inhibited.

The drug also has an antipruritic and decongestant effect. When treated locally, the medication reduces the inflammatory process by interfering with the migration of lymphocytes and macrophages into the affected tissues, as a result of which cellular infiltrates resolve more quickly. If the dosage of the ointment is not exceeded, the drug only accumulates in the epidermis or mucous membrane and almost does not penetrate into the blood, so there are no systemic side effects.

Pharmacokinetics

There is currently no complete information about the drug. It is known that the hormone can be absorbed into the blood, and it also has a systemic effect. The drug does not completely bind to plasma proteins; from 40 to 90% of the drug enters the plasma.

The medication prolongs placental protection and the BBB. The drug is excreted through the kidneys with urine, breakdown occurs in the liver.

How to use: dosage and course of treatment

Studies of the safety and effectiveness of the drug in pregnant and lactating women have not been conducted. There is no precise data on the penetration of corticosteroids into breast milk when applied topically. However, the risk cannot be completely eliminated.

The use of the drug in pregnant and lactating women is allowed only as prescribed by the attending physician, when the expected therapeutic effect for the mother exceeds the potential risk for the fetus or child. The duration of use should not exceed 7-10 days.

When to use

The instructions for use of the Hydrocortisone suspension say that the medicine is used in a state of shock. The latter can be caused by various reasons:

1. Injuries received.
2. During and after surgery.
3. Thermal and chemical burns.
4. The action of toxic substances.
5. Cardiogenic shock due to extreme left ventricular failure.

"Hydrocortisone" for inhalation is prescribed to patients with severe bronchial asthma, with complications of the extreme stage of the pancreas. The medication is indicated for rheumatoid arthritis and other connective tissue diseases.

The drug is used in the complex treatment of severe liver damage, for example, hepatic coma, acute form of hepatitis, if the adrenal glands do not produce enough aldosterone and cortisol.

Complex allergic reactions are also treated with Hydrocortisone. This includes anaphylactic shock, swelling of the brain, which can occur due to a tumor, injury or surgery.

In the same cases, “Hydrocortisone” is used for inhalation or injection.

Indications for the simultaneous use of Dioxidin and Hydrocortisone

A combination of drugs is often used to eliminate infectious and inflammatory processes, including:

• otitis;
• conjunctivitis;
• iridocyclitis;
• bacterial bronchitis;
• complicated rhinitis;
• acute or chronic sinusitis;
• severe form of nasopharyngitis.

Simultaneous drug therapy is also prescribed to eliminate an allergic reaction accompanied by an infection.

Who should not use the medicine

Under no circumstances should the drug be used in patients:

1. With individual intolerance to the composition of the drug.
2. Diseases in which pathological bleeding occurs. These include hemophilia and thrombocytopathy.
3. Allergy to the composition of the medicine.
4. Inflammation of the joints of an infectious nature such as purulent arthritis.
5. Infectious diseases of tendons, periarticular soft tissues, articular ligaments.
6. Violation of the body's hemostatic system.
7. Destruction of bone tissue when it is replaced by tumor-like formations or other pathological tissue.
8. Bone fractures inside the joint.
9. History of osteoplastic surgery.
10. Pathologies in which some part of the skeleton undergoes necrotic changes. These include systemic scleroderma, Calve's disease, rheumatoid arthritis, and Kibneck's disease.

The mechanism of action of the Hydrocortisone suspension is such that it can be used for children in case of absolute indications and upon reaching three years of age.

How to use

Whether the patient has contraindications to the use of the Hydrocortisone suspension, the doctor must find out, and he also prescribes the dose of the drug. The suspension can be administered in several ways:

1. Periarticularly, that is, into the intraarticular bursae.
2. Intra-articularly, the suspension is injected into the joint cavity.
3. Intramuscularly. The drug is injected into soft tissues.

During one day, you can inject the drug into only three joints. Injections are repeated only after three weeks. Frequent use of Hydrocortisone joint suspension leads to depletion of hyaline cartilage. Because of this, a repeat course can be prescribed no earlier than three months later.

For adults, the dose is calculated individually. It all depends on the severity of the symptoms and the size of the joints.

The dosage of the Hydrocortisone suspension is recommended in the following volumes:

1. Adolescents over 14 years of age and adults are prescribed from 5 to 50 milligrams of medication into the intra-articular bursae or the joint itself.
2. Children over three years of age are prescribed from 5 to 30 milligrams of the drug periarticularly or intraarticularly.

The drug begins to act in different ways, from 6 to 25 hours. The therapeutic effect lasts from several days to several weeks. During therapy, medications are used that accelerate sodium excretion. The drug is injected intramuscularly as deep as possible into the buttocks. The daily norm cannot exceed 1500 milligrams. You can use no more than 300 milligrams at a time.

The instructions for the Hydrocortisone suspension for inhalation say that no more than three procedures can be performed per day. You are allowed to use no more than 30 milliliters of the active substance per day. Inhalation can be carried out for no longer than 10 minutes. To use the drug, use a compressor nebulizer; other devices are not suitable.

If the patient suffers from rhinitis or a prolonged runny nose, the doctor prescribes the use of Hydrocortisone Richter suspension in the nose. In this case, the drug is mixed with saline and instilled into the nasal sinuses twice a day. During inpatient therapy, doctors prescribe complex drug-based nasal drops.

If a patient is diagnosed with inflammation of the outer ear, the doctor prescribes instillation of a Hydrocortisone suspension into the ear. According to the instructions for use, no more than three drops can be instilled into each ear. For inflammation of the middle ear, you can instill four drops. Recommendations are given for adults; for children, the doctor prescribes a much lower dosage. Until the age of fourteen, you can instill no more than two drops in one ear.

Recipe, composition and instructions for using complex nasal drops

No matter how harmless a runny nose may seem, it can cause a lot of inconvenience and be accompanied by serious complications. Improper treatment of rhinitis can lead to chronic sinusitis, tonsillitis and other undesirable consequences associated with the spread of infection and inflammation to surrounding healthy tissue. Complex nasal drops can relieve the symptoms of the disease.

Thanks to the combined composition, it is possible to obtain a double, sometimes even triple, effect when using one drug. Medical experience shows the high effectiveness of such drugs, which is why they are often prescribed in otolaryngology.

Combined solutions for nasal use have several components, the mechanism of action of which is aimed at eliminating symptoms, the causes of the disease, as well as preventing complications.

You can prepare the medicine at home using a folk recipe. In addition, the drug can be purchased at a pharmacy, which is a more acceptable option.

The fact is that self-made medicinal products may have inaccurate composition or errors in preparation. This can lead to overdose and serious adverse reactions.

On the other hand, the drug may be ineffective due to an insufficient dose of each of the components.

It is recommended to purchase complex drops for a child in pharmacies to avoid worsening the condition.

Combination medications are usually used when monocomponent medications are ineffective.

Features of complex drops

Complex nasal drops may include the following “ingredients”:

• antihistamines. They reduce tissue swelling, rhinorrhea, block histamine receptors, which stimulate the development of allergies;
• vasoconstrictors – reduce the diameter of blood vessels at the site of drug administration. Clinically, this is manifested by a decrease in swelling of the mucous membrane and the volume of mucous secretions. With a decrease in nasal congestion, nasal breathing is restored;
• antimicrobial. Antibacterial and antiviral substances inhibit the vital activity of microbes and clear the pathological focus of infection;
• hormonal – have a powerful anti-inflammatory, decongestant, antihistamine effect;
• immunocorrective. Depending on the purpose of therapy, immunostimulating or immunosuppressive components are prescribed;
• homeopathic, herbal remedies. They have a mild therapeutic effect and have a minimal number of side effects.

The use of combination drugs without an accurate diagnosis is prohibited. For example, for a viral infection, medications with antibacterial activity should not be used. In the atrophic form of rhinitis, the use of vasoconstrictor drugs is contraindicated.

Components of drugs

The basis of most complex medicines is saline solution or antiseptics, such as Dioxidin, Protargol or Furacilin.

Antimicrobial components, which are included in the prescription of drugs, are necessary for the treatment of infectious sinusitis or rhinitis. In childhood, such medications are prescribed for adenoiditis.

Antihistamines include Diphenhydramine or Suprastin. They are part of medications used for allergic rhinitis. Their effect is clinically manifested by a decrease in itching sensations, soreness in the nasopharynx, as well as restoration of nasal breathing.

Among the components with vasoconstrictor activity, Naphthyzine and Phenylephrine are used. They are especially dangerous when used in high doses for a long time. A common complication of such therapy is drug-induced rhinitis and drying out of the nasal mucosa.

Antibacterial components can be represented by Gentamicin, Amikacin, Ceftriaxone. Their use is justified for bacterial inflammation of primary or secondary origin.

Representatives of the hormonal group are Hydrocortisone and Dexamethasone. They quickly reduce the severity of edema and inflammation, but the full therapeutic effect can be expected only after three days from the start of therapy.

As for vitamins A, E, essential oils, plant extracts, they can be the main or additional components. One of the common side effects of natural treatments is allergies.

Application

To obtain the maximum therapeutic effect, complex nasal drops must be instilled after preliminary cleansing of the nasal mucosa.

For this, Aqua Maris, Marimer, Morenasal are recommended. After rinsing with saline solution, it is advisable to blow your nose well.

When using the solution to moisturize the mucous membrane, after cleansing the nose, you can re-drop two drops of it. The number of procedures can reach four per day.

Effective recipes

To choose the most effective prescription, you need to know the cause of the disease and the effect of the components of the medicine.

Recipe No. 1

For adenoiditis, severe rhinorrhea and microbial runny nose, you can use medications based on a vasoconstrictor and antiseptic component.

For preparation you will need 0.05% Naphthyzin (1 ml) and Dioxidine (1 ml). After thorough mixing, you can drip two drops three times a day.

Recipe No. 2

More complex medicine includes:

1. vasoconstrictor component (Mezaton 1% volume 1 ml);
2. hormonal (Hydrocortisone 2.5% volume 2 ml);
3. antibacterial, for example, Lincomycin 2 ml;
4. antiseptic – Dioxidin 0.05% – 5 ml.

Given the presence of a vasoconstrictor, it is allowed to instill nose drops no more than three times per day. The drugs are used for infectious sinusitis, as well as other bacterial diseases of the ENT organs.

Recipe No. 3

In case of allergic rhinitis, the following complex medicine can be used. It includes:

1. vasoconstrictor “ingredient” – Naphthyzin in the volume of half a bottle;
2. antiseptic – Dioxidin – half an ampoule;
3. hormonal (Dexamethasone – 1 ml);
4. antihistamine (Diphenhydramine – 1 ml).

The last two drugs are necessary to block histamine receptors. This is necessary to relieve an allergic reaction and alleviate the general condition.

It is not recommended to independently invent recipes for nasal drops, since this requires deep knowledge in pharmacology and practical experience in using this medicine.

There are a large number of combination drugs that can be purchased at the pharmacy.

Polydexa

The drug contains two antibacterial (neomycin, polymyxin B), hormonal (dexamethasone), and vasoconstrictor components. The medicine is available in the form of a solution for nasal administration.

The therapeutic effect is expressed by the powerful anti-inflammatory, anti-edematous and antimicrobial properties of the drug. In treatment, it should be remembered that Polydexa will not be able to help in the presence of coccal flora, anaerobes and bacilli in the inflammatory focus.

Polydexa is prescribed for infectious rhinitis to reduce inflammation and nasal congestion.

Contraindications, adverse reactions

Contraindications include:

• individual intolerance to components;
• viral infection in the active stage.

Note that the drug can give a positive doping test in athletes. The therapeutic effect should be assessed after 4 days from the start of therapy. Typically the therapeutic course is 7 days. If you adhere to the recommended doses, systemic reactions are not observed.

During the lactation period and pregnancy, the independent use of Polydexa is prohibited.

In most cases, the drug is well tolerated. If doses are exceeded, the following symptoms may appear:

1. irritation of the mucous membrane;
2. allergic reaction;
3. sneezing;
4. itchy sensations in the nasal cavities.

Long-term antibiotic therapy is accompanied by activation of a fungal infection, which is quite difficult to fight.

Doses

The medicine is applied topically by instilling three drops into the nasal passages twice a day. If treatment is carried out on a child, the dose should not be exceeded - 1 drop twice.

Vibrocil

Combination medications include Vibrocil. Its composition is represented by an antihistamine, vasoconstrictor component. Clinically, the effect of the drug is represented by:

1. reduction of itching, soreness in the nasal passages;
2. decreased tissue swelling;
3. eliminating nasal congestion;
4. reduction in the volume of mucous secretions.

Vibrocil does not disrupt the physiological functions of the mucous membrane, which ensures its high resistance to irritating environmental factors, including allergens.

The drug is prescribed for seasonal or year-round rhinitis of allergic origin. It can be used in the treatment of otitis to provide ventilation of the auditory cavity, as well as reduce swelling of the mucous membrane of the Eustachian tube.

Vibrocil is used before diagnostic procedures or in the postoperative period to prevent complications.

Dosage

For therapeutic purposes, two drops are prescribed three times a day. The drug should be instilled onto the cleansed mucous membrane of the nasal passages. For this you can use Dolphin, Aqualor or Salin. Children from the age of two should drip one drop 2-3 times.

Side effects

If you use the medicine for a long time or use it uncontrolled, then over time there will be side effects characteristic of glucocorticosteroids.

Among them:

1. Water-electrolyte imbalance, excess and accumulation of sodium in the body, deficiency and leaching of potassium.
2. Increased blood pressure at the time of use or permanently, heart failure.
3. Cessation or retardation of growth in children, death of bone tissue, insufficient blood supply to the joints, decreased tone, muscle mass and muscle strength.
4. Constant nausea, vomiting, formation of ulcers on the mucous membrane of the stomach and esophagus, gastric bleeding, inflammation of the digestive tract.
5. The appearance of acne, stretch marks, increased skin sensitivity, rashes, the appearance of terminal hair in women.
6. Headaches, mental disorder, sleep disturbance, dizziness, drowsiness, insomnia, euphoric or depressive state.
7. Increase and accumulation of glucocorticosteroids, adrenal dysfunction, delayed puberty, damage to the adrenal cortex, disruption of menstrual cycles.
8. Permanent increase in intraocular pressure, ulcerative lesions of the cornea, development of glaucoma.

If the patient has a latent form of tuberculosis, then it may worsen while taking medications. This also includes an increased level of white blood cells, the risk of thromboembolism and blood clots.

Interaction with other drugs

It is not enough to know how to use the Hydrocortisone suspension for physiotherapy or intramuscular administration; you also need to understand its combination with drugs.

Patients with adrenal insufficiency should not be treated with drugs derived from barbituric acid.

“Hydrocortisone” increases glucose levels, so patients with diabetes are prescribed antidiabetic tablets taking this into account.

The combination of Hydrocortisone with medications that inhibit blood clotting in therapy causes a weakening or strengthening of the effect of the latter.

Ketoconazole and Erythromycin counteract the breakdown of Hydrocortisone.

The drug should not be used in combination with medications that lower blood pressure, because the latter lose their effectiveness.

Medicines active against HIV increase the concentration of the hormone in the blood. Combination with antitumor drugs threatens bone marrow damage.

The use of hormonal contraceptives and Hydrocortisone provokes an increase in hormones in the blood.

The effectiveness of the drug is reduced by:

1. Derivatives of barbituric acid.
2. Antiepileptic drugs.
3. Non-steroidal anti-inflammatory drugs.
4. Antiprogesterone drugs.
5. Medicines from certain antibiotics that act on the microbacteria of leprosy and tuberculosis.

Features of application

The drug is prescribed with all precautions and under constant medical supervision for the elderly and children. In the latter, constant use of the drug leads to slower growth, the formation of biological sexual characteristics, and puberty. Growth failure can occur at any age, from infancy to adolescence. This is irreversible.

Prescription for vital signs should be carried out in a minimum dosage and a short course.

Very rarely, but the drug is prescribed to infants. The composition contains benzyl alcohol, which makes it impossible to use for up to three years, but in exceptional cases this is not paid attention to.

The hormone also provokes the growth of fat deposits in the thighs and abdomen, so it is necessary to monitor the child’s weight. Now a suspension for children with a milder effect is being created.

Elderly patients note systemic and pronounced local clinical manifestations. The consequences of taking it can be:

1. Increased blood pressure.
2. Osteoporosis.
3. Excessive sensitivity and irritation of the skin.
4. Dryness.
5. Increased glucose levels.

Overdose

Locally. Apply a thin layer of ointment to the affected skin surface no more than 3-4 times a day. The course of treatment is 1-3 weeks. The dose of the drug used for 1 week should not exceed 30-60 g. If itching in the anus, before applying the drug, wash the affected area with warm water and soap, then with water and dry the skin surface with a towel or napkin.

• Skin treatment with 1% ointment is carried out twice or thrice a day. A thin layer of the drug is applied only to the affected areas. The duration of use is determined by the doctor (based on the effectiveness of treatment and the nature of the disease). Typically treatment is carried out within 6-14 days.
• Eye ointment in the form of a strip 1-2 cm long is placed behind the lower eyelid. This treatment is prescribed 2-3 times a day for 7-14 days.

Use in a higher dose may intensify the local reaction to the ointment, but upon withdrawal, such symptoms pass quickly enough.

Precautionary measures

Medical reviews of the Hydrocortisone suspension are very ambiguous, but the drug is effective if the rules are followed. For example, you should not stop treatment suddenly. Doses are reduced gradually; sudden cessation is fraught with withdrawal syndrome. General malaise, joint pain and fever appear. The syndromes are characteristic of adrenal insufficiency, so it is important that the doctor makes the correct diagnosis.

In what situations should precautions be taken?

1. The drug can be prescribed to children only for health reasons. If it is possible to avoid the use of a suspension, then use an ointment. The dose is reduced to a minimum, and the course of treatment is shortened.
2. The patient's condition must be monitored in case of latent tuberculosis.
3. If the drug is used during pregnancy, children are monitored for a very long time. This is necessary to detect adrenal insufficiency in time.
4. After cessation of treatment, relative adrenal insufficiency may develop. It may persist for several weeks or even months. If the condition worsens, then the medication is resumed. At the same time, mineralocorticoid therapy is carried out.
5. During therapy, glucose levels, blood pressure and blood clotting are monitored.
6. Large doses of hormones reduce the synthesis of antibodies, which means vaccination cannot be carried out during and after treatment.
7. It is necessary to follow a protein diet. All foods containing sodium are excluded from the menu during treatment, but potassium foods, on the contrary, are preferred.
8. Injections can be given at home or in a hospital, but proper sanitation must be observed. Antiseptics and aseptics must be used to prevent infection from getting into the injection site.

Generics

“Hydrocortisone” is not the only medicine in its category; there are many analogues that are suitable for indications and method of use.

Among them:

1. "Dexamethasone."
2. "Polcortolon."
3. "Prednisolone."
4. "Diprospan".
5. "Solu-medrol."
6. "Cortisone".
7. "Hydrocortisone Acetate".
8. "Solu-Corter."

The price for Hydrocortisone suspension is often higher than for other drugs, but they have completely different contraindications. Before use, you should consult your doctor.