Antibiotics for sinusitis in tablets: indications for use and side effects

Composition and release form

Unidox Solutab is produced in the form of dispersible tablets. Their active component is doxycycline monohydrate, which each tablet contains 100 mg in terms of doxycycline.

In addition to the active substance, the composition also contains auxiliary components: saccharin, MCC, hypromellose, magnesium stearate, fine hydroxypropyl methylcellulose, lactose monohydrate. These components of the drug ensure rapid disintegration of the tablets and release of the active ingredient . In addition, they serve as tablet fillers, give them a pleasant taste, and ensure uniform mixing of all ingredients during the production process.

Pharmaceutical action

Doxycycline is an antibiotic that has a bacteriostatic effect. It inhibits the synthesis and metabolism of proteins contained in the cell membrane of microbes. In addition, doxycycline can disrupt the connection of RNA with ribosomal membranes. This effect ensures the high effectiveness of the drug in the fight against many gram-positive and gram-negative bacteria.

Unidox Solutab is especially effective against microbes that are in the stage of division and growth. At the same time, it has practically no effect on microorganisms that have entered the dormant stage.

Doxycycline is rapidly absorbed after oral administration from the gastrointestinal tract. The highest level of the drug in the blood is achieved 2 hours after administration. The half-life of the drug is 16-18 hours with a single dose and 22-24 hours with repeated use.

Doxycycline has the ability to penetrate the blood-placental barrier, as well as into breast milk.

Pharmacodynamics and pharmacokinetics of "Doxycycline"

As mentioned earlier, Doxycycline is a broad-spectrum drug and is active against:

  • gram-positive cocci (Staphylococcus aureus);
  • coagulase-trizacelous staphylococci;
  • streptococci (S.pneumoniae, S.pyogenes, S.agalactiae, S.viridans);
  • gram-negative cocci (N.meningitidis, N.gonorrhoeae, B.catarrhalis);
  • rods (Bordetella, Brucella spp., Calymmatobacterium granulomatis, Campylobacter spp., F.tularensis, H.influenzae, H.ducreyi, Legionella, P.multocida, Yersinia spp.);
  • Vibrionaceae strains (V.cholerae, V.parahaemolyticus);
  • microorganisms (Helicobacter pylori, Chlamydia spp., Rickettsia spp., Coxiella spp.);
  • spirochetes (Borrelia burgdorferi, Leptospira interrogans, Treponema pallidum);
  • Mycobacterium spp., Mycoplasma pneumoniae, Ureaplasma urealyticum;
  • protozoa (Plasmodium falciparum, Entamoeba histolytica).

The drug has a bacteriostatic effect, i.e. causes inhibition of the proliferation of microorganisms.

Antibiotic for sinusitis
The drug belongs to the tetracycline series of antibacterial agents and is a semi-synthetic antibiotic. But, in terms of antibacterial activity, Doxycycline is superior to natural tetracyclines. However, it is worth knowing that there is cross-resistance to other tetracyclines, as well as penicillin antibacterial agents.

When Doxycycline is administered orally, it is quite well absorbed from the gastrointestinal tract into the systemic circulation, where its binding to blood proteins is 80 - 90%. 60% of the drug is excreted through the intestines, and 40% through the kidneys in 72 hours.

When taking Doxycycline, photosensitivity may increase, so it is necessary to avoid exposure to the sun and exposure to artificial ultraviolet radiation during therapy and for 4 to 5 days after its completion.

Indications for use

According to the instructions, it is recommended to take Unidox Solutab for diseases of various organs and systems that were caused by bacteria sensitive to doxycycline. These include:

  • sinusitis,
  • tracheitis,
  • pneumonia,
  • bronchitis,
  • tonsillitis,
  • otitis,
  • pharyngitis,
  • lung abscess,
  • cystitis,
  • urethritis,
  • prostatitis,
  • pyelonephritis,
  • urogenital mycoplasmosis,
  • uncomplicated gonorrhea,
  • syphilis,
  • endometritis,
  • cholecystitis,
  • gastroenterocolitis,
  • traveler's diarrhea,
  • chlamydia,
  • infections of the skin and soft tissues,
  • osteomyelitis,
  • peritonitis,
  • sepsis,
  • leptospirosis,
  • eye infections, etc.

Is it justified to use for sinusitis?

Unidox Solutab is often used for sinusitis. It is especially effective for sinusitis caused by Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Proteus mirabilis, as well as atypical pathogens Mycoplasma spp. and Chlamydia spp.

It should be noted that Unidox Solutab is not a first-line drug for the treatment of this disease. However, it is somewhat inferior in effectiveness to drugs from the group of penicillins and macrolides, so it is used when it is impossible to take the latter . This could be due to:

  • allergy and hypersensitivity to macrolides and penicillins,
  • resistance of the strains that cause sinusitis to the action of first-line drugs,
  • suspicion of an atypical infection.

Another important feature of the drug is its excellent permeability to tissues and body fluids, which is very important for sinusitis.

The most correct decision when choosing a suitable remedy for sinusitis is to carry out bacteriological culture to determine the sensitivity of microbes to the drug. If such sensitivity is confirmed to Unidox Solutab, then its use is completely justified.

Features of substance distribution

Doxycycline is a drug that is quickly absorbed into the blood after entering the body. It is not destroyed by stomach acids, so it can be taken regardless of food. However, the instructions recommend taking capsules or tablets with plenty of water.

An important requirement for an antibiotic for sinusitis is the ability to accumulate in large quantities in fluids and tissues. This drug fully meets this requirement. It creates high concentrations in secretions and tissues, which enhances the effect of the drug on pathogenic bacteria.

This tetracycline penetrates well into breast milk and accumulates in bone tissue. This is due to the strict prohibition of Doxycycline during pregnancy, lactation and childhood.

The drug is excreted from the body through the kidneys and gastrointestinal tract. For chronic compensated liver and kidney diseases, it is not necessary to reduce the dose of the substance.

Possible consequences of use

Unidox Solutab is quite well tolerated by patients. But, like any other drug, the drug can cause the development of undesirable effects. During use, the following side effects of Unidox Solutab may be observed:

  • nausea,
  • diarrhea,
  • anorexia,
  • angioedema,
  • staining the tongue black,
  • hives,
  • hemolytic anemia,
  • rash,
  • candidiasis,
  • cholestasis,
  • liver damage,
  • thrombocytopenia,
  • vestibular disorders,
  • slowing down osteogenesis.

How to use

The drug should be taken only as prescribed by a doctor. The duration of the course of treatment and dosage of use are selected individually, taking into account the type of disease, the severity of the pathological process, the patient’s age and the presence of concomitant diseases. On average, the course of treatment ranges from 5 to 10 days. Taking tablets is most often prescribed once a day, in rare cases - 2 times.

The convenience of using Unidox Solutab tablets lies in the possibility of taking them in different ways. The tablets can be swallowed whole with water, chewed or diluted in water before use.

It is important to adhere to the doses recommended by your doctor and take them at regular intervals. To reduce irritation of the mucous membrane of the stomach and esophagus, it is better to take the tablets in a standing position with a sufficient amount of water. It is recommended to take the medication with meals.

Drug interactions

Medicines that contain magnesium, aluminum and calcium significantly reduce the absorption of doxycycline. Therefore, medications should be taken at intervals of at least three hours. In addition, antibiotics from the tetracycline group suppress intestinal microflora. In this regard, the prothrombin index decreases. Indirect anticoagulants should be taken together with Unidox Solutab tablets with caution.

Patients using hormonal contraceptives should consult a gynecologist before starting antibiotic treatment. The problem is that doxycycline significantly reduces the effect of contraceptives. Possible cycle disruption in women. In some cases, the frequency of acyclic bleeding increases.

People with hypertension should not take antibiotics together with retinol. Possible increase in intracranial pressure.

Features of application

The drug can cause photodermatitis, so it is necessary to avoid prolonged exposure to the sun during treatment and for several days after its completion.

During drug therapy, it is possible to develop a superinfection caused by strains of bacteria that are insensitive to it . If this happens, you should immediately stop taking Unidox Solutab tablets and begin appropriate treatment.

When using the drug for a long time, it is necessary to monitor the condition of the kidneys, liver and laboratory blood parameters.

With long-term antibiotic therapy, the development of dysbacteriosis and hypovitaminosis is possible.

In some cases, during treatment or within 2-3 weeks after its completion, diarrhea caused by Clostridium dificile may develop. If the degree of diarrhea is mild, then stopping the drug and taking Colestipol or Cholestyramine is sufficient. In more severe cases, it will be necessary to restore the water-electrolyte balance and take Metronidazole or Vancomycin.

Use in childhood

Doxycycline contained in Unidox Solutab disrupts the development of bones and teeth. In addition, it leads to irreversible changes in tooth color and the development of enamel hypoplasia. Therefore, its use is prohibited in pediatrics. The medication is allowed to be taken only after reaching 8 years of age.

Use during pregnancy and lactation

Unidox Solutab tablets should not be taken during pregnancy. The tetracycline antibiotic Unidox Solutab has the ability to penetrate the blood-placental barrier. This has a negative effect on the development of the fetus, which is manifested by inhibition of osteogenesis . In addition, the use of this medicine also negatively affects a woman’s body due to the increased risk of serious liver damage.

Before prescribing Unidox Solutab, you should make sure that you are not pregnant.

During breastfeeding, taking the medicine is also prohibited. This is because doxycycline passes into breast milk and has a negative effect on the development of bone tissue in the baby. If taking an antibiotic of this group is necessary, then breastfeeding should be stopped for the period of treatment and complete removal of the drug from the body.

If liver or kidney function is impaired

Taking the medicine is prohibited in cases of serious dysfunction of the liver and kidneys. For milder forms of liver dysfunction, a dose reduction is required.

Alcohol and drug

The simultaneous consumption of alcoholic beverages along with the medicine is prohibited. This combination mutually enhances the toxic effect on the liver and can cause the development of toxic hepatitis. In addition, the therapeutic effect of doxycycline is reduced. It is advisable not to drink alcohol earlier than a week after completion of treatment.

Combination with other drugs

When Unidox Solutab is prescribed simultaneously with estrogen-containing contraceptives, the reliability of their contraception decreases and the risk of acyclic bleeding increases.

A break of at least 3 hours is necessary after taking antacids and magnesium-containing laxatives, as they reduce the effectiveness of doxycycline.

When taken simultaneously, it reduces the effectiveness of penicillin and cephalosporin antibiotics.

Unidox Solutab: instructions for use

Unidox Solutab

Unidox Solutab is an effective antibacterial agent. The drug is actively used in the treatment of urological and infectious diseases, diseases of the skin, venereal and ENT organs, and inflammation of the pelvic organs.

Today, this highly effective drug has become an innovative remedy that belongs to a completely new generation of antibiotics: you can take the medicine in three different forms - in the form of tablets, dissolving this tablet in water or in the form of syrup. According to the drug itself, it has a high degree of bioavailability and effectiveness.

During the production process, the product does not use substances such as sodium, gluten and sugar, which allows people suffering from hypertension and diabetes to take the medicine.

This non-standard composition of the drug makes it innovative in the consumer market.

An antibiotic should not be used together with alcohol, as the medication enhances the effect of alcohol on the body, which negatively affects the liver.

The drug belongs to the group of tetracyclines, long-lasting and broad-spectrum. In any pharmacy you can buy Unidox Solutab for 350 rubles. Instructions for use also include a description of the release form of the product: tablets, with the active substance doxycycline monohydrate, auxiliary components.

The tablet has an active effect in the body, destroying entire colonies of harmful bacteria: gram-positive and gram-negative, gonorrheal microorganisms, chlamydia, plasmodium, etc.

The pharmacological effect of the drug lies in its active action on different groups of microorganisms and their strains.

All components of the drug are absorbed very quickly and reach a high concentration after 2 hours if 200 mg of the drug was taken.

The human body may become resistant to the active substance doxycycline and the effectiveness of the drug will decrease.

Therefore, so that pathogen strains cannot develop resistance to the antibiotic and the drug effect does not decrease, the treatment regimen should not be violated and the recommended dosage of the drug should not be exceeded.

The drug is indicated for the treatment of diseases such as:

  • Infectious diseases of the respiratory tract (acute bronchitis, tracheitis, community-acquired and lobar pneumonia, lung abscesses, etc.).
  • Diseases of the ENT organs (tonsillitis, sinusitis, etc.).
  • Diseases of the genitourinary system (urology, venereology, female infectious diseases).
  • Sexually transmitted sexually transmitted diseases (syphilis, chlamydia, gonorrhea, etc.).
  • Infection of the gastrointestinal tract (cholecystitis, cholera, traveler's diarrhea, cholangitis, etc.).
  • Infections of soft tissues and skin, acne.
  • Eye infections.
  • Prostatitis and ureaplasmosis.
  • Other infectious diseases.

There are certain restrictions in taking the drug Unidox Solutab; the instructions for use allow it to be used for the prevention of infectious diseases and postoperative complications, expressed in the form of the development of purulent manifestations.

However, like any other antibiotic, Unidox Solutab also has its contraindications for use:

  • Not recommended for severe forms of kidney and liver diseases.
  • Pregnancy and lactation.
  • For porphyria.
  • Children under 8 years old.
  • If there is an individual intolerance to the components of the drug.

It is highly not recommended to use the medicine if you have a very strong intolerance to tetracyclines, a sensitive body to antibiotics, or if your kidneys or liver are in critical condition.

During pregnancy, the drug is not used in the first and third trimesters, because the antibiotic can disrupt the development of bone tissue in the fetus and harm the formation of teeth.

If during lactation there is still a need to take the drug, then breastfeeding the baby is stopped so that doxycycline does not enter the child’s body along with mother’s milk.

If the recommended dosage of the medication is not followed, side effects may also occur:

  • allergic reactions;
  • gastrointestinal disorders;
  • anemia;
  • liver damage;
  • nausea, vomiting;
  • increased intracranial pressure;
  • headache;
  • candidiasis;
  • increased sensitivity to ultraviolet rays;
  • vestibular disorders.

Unidox Solutab: how to take
If an overdose of the drug occurs, it is necessary to urgently rinse the stomach, induce vomiting, take activated charcoal, and laxatives. In case of severe overdose, hospitalization is required, during which a specialist doctor will carry out the necessary clinical actions.

Reviews from doctors who have used the product to treat gynecological infectious diseases, urology and other diseases are quite positive. Any harmful microorganism is susceptible to the action of an antibiotic in the shortest period of time. Patients note the ease of tolerability of the antibiotic, the convenience of taking the drug (suspension, tablet), and the short course of treatment.

Analogues of the drug belonging to the group of tetracyclines: Doxycycline hydrochloride, Tigacil, Unidox, Tetracycline, Dovicin, Doxylan, Doxibene. Among foreign analogues, doctors recommend using Vibramycin-D and Doxa-M.

When choosing an analogue, you must understand that all similar drugs will not give such a fast and effective effect as the original, so it is much better to still use Unidox Solutab.

Among consumers, there is an opinion that the drug Doxycycline and Unidox Solutab are complete analogues. This is a somewhat erroneous understanding, although these drugs contain one active substance - doxycycline, a broad-spectrum antibiotic.

The advantages of Unidox Solutab over the second medicine are that the first one was created using modern technology, which allows the antibiotic to be absorbed into the blood faster, while the second medicine is slower in action.

If patients take Doxycycline for a long time, this causes destruction and yellowing of tooth enamel.

It is not for nothing that manufacturers call the product “patient-friendly”: all components undergo several stages of purification, which makes it safe and does not cause side effects.

Drug interactions Unidox Solutab:

  • If the patient is taking medications that contain iron, magnesium, calcium, aluminum, or laxatives, Unidox Solutab is taken only after 3 hours.
  • Doses of indirect anticoagulants taken with this drug are subject to adjustment.
  • The medicine reduces the effectiveness of bactericidal antibiotics taken, which also treat the disease.
  • The active substance of the drug, doxycycline, increases the risk of acyclic bleeding if you are taking hormonal contraceptives at the same time as the drug.
  • Simultaneous use of the drug and retinol leads to an increase in intracranial pressure.

Unidox Solutab: how to take the drug for the treatment of prostatitis and other diseases

Tigacil: analogue of Unidox Solutab
The drug is widely used in urology, in particular, for the treatment of prostatitis, since it contains one of the most effective substances - tetracycline.

Unidox Solutab, how to take for prostatitis:

The course of treatment can last from 2 to 3 weeks, but it all depends on what stage of development the disease is in, what your body characteristics are and individual contraindications.

The doctor may change the daily dose of the drug.

Note that a child can also be treated with such an antibiotic, but only at the age of 8 years.

Food does not affect the intake of the drug in any way, which is why it is most often taken with food (food helps the medicine to be absorbed into the blood and plasma more quickly).

The daily dose of the drug is 2 tablets (1 in the morning and 1 in the evening).

The prefix to the main name of the drug “solutab” indicates that this drug can be taken in different forms that are convenient for you. Not all patients can take the drug entirely or even chew it. For many, it is much easier to drink syrup or suspension. That's why manufacturers have proposed such a reasonable solution as 1 tablet, which you can drink as usual or grind it into powder and dissolve in water.

The advantage of this form of tablet is that the composition dissolved in water receives higher biological activity, which means it is absorbed faster in the gastrointestinal tract, quickly enters the bloodstream and tissues of internal organs, where it acts on various types of infections.

Unidox Solutab, how to take it in the treatment of other pathologies:

  • For the treatment of uncomplicated gonorrhea, tablets are prescribed 2 times a day (100 mg each). The course of treatment lasts 1 week. The doctor may also recommend therapy in which you take tablets in 2 doses (300 mg at a time) over 1 day. Chlamydia is treated in the same way.
  • Primary syphilis. The course of treatment is 2 weeks. Take tablets 2 times a day, 100 mg.
  • Secondary syphilis. The course of treatment is 28 days. Take tablets daily, 2 times a day, 100 mg.
  • Uncomplicated urogenital infections. The course of treatment is 7 days. Take tablets daily, 2 times a day, 100 mg.
  • Acne, endometritis. The course of treatment is from 6 to 12 weeks. Dosage: 1 tablet (100 mg)/day. For acne, the drug affects every pimple that has already suppurated and suppresses the entire pathogenic environment.
  • Typhus is treated with a single dose of tablets. Depending on the severity of the disease, 100 mg or 200 mg of medication is prescribed at a time.
  • Prevention of traveler's diarrhea. On the first day of the trip, take 200 mg (1 or 2 times), then 100 mg/day. The course of admission cannot be more than 3 weeks.
  • Prevention of malaria is carried out immediately before travel, 1 or 2 days before the trip. During these days, take 100 mg/day. After returning home, the preventive course can last up to 4 weeks.
  • Prevention of abortion to prevent the development of infectious diseases. Before surgery, 100 mg is administered for 1 hour and 200 mg immediately after surgery.
  • For streptococcus, the course of treatment is at least 10 days.

When a patient comes to the clinic for treatment, examinations and tests are carried out, based on the results of which the doctor prescribes therapy with this antibiotic.

Such a wide range of diseases that can be treated with this remedy makes it popular both among doctors and patients.

Dosage of Unidox Solutab

Dosage of Unidox Solutab
An antibiotic of such a strong effect on the body is always taken on the recommendation of a doctor and strictly according to the dosage regimen he has drawn up. Especially the dosage of Unidox Solutab should not be exceeded so as not to cause side effects.

We also do not forget that this drug can be addictive and its effect on groups and strains of harmful microorganisms may be weakened.

The drug can be taken in two ways: taking a tablet with plenty of water, or you can dissolve 1 tablet in water (about 20 ml) and drink the resulting syrup, the taste of which is quite pleasant, which is why children are recommended to use tablets dissolved in water.

The medication is most effective when taken with food, but is not recommended immediately before bedtime.

The course of treatment, on average, for general and non-severe infectious diseases ranges from 5 to 10 days.

The maximum possible dose that will not cause an overdose and the development of side effects is 300 mg / day or taking 600 mg of the drug for 5 days. This dose size is possible if the patient has a gonococcal infection.

Unidox Solutab, recommended dosage for use:

  • For adults and children over 8 years of age and with a body weight over 50 kg: on the first day, 2 tablets (200 mg) in 1 or 2 doses. Subsequent days of therapy - 1 tablet (100 mg) / day.
  • For children aged 8 to 12 years, with a body weight of less than 50 kg, on day 1 of therapy it is recommended to take 4 mg / day, and on subsequent days of treatment - 2 mg / day per 1 kg of weight.
  • For the treatment of prostatitis, the doctor prescribes 1 tablet/day.
  • For the treatment of other diseases, the doctor develops an individual dosage regimen. On average, the patient takes from 1 to 2 tablets per day.
  • For the prevention of Unidox Solutab, 1 tablet is used for a short period. As a rule, the period of prophylaxis never exceeds 3 weeks.

This drug has some advantages over other antibiotics:

  • You can take the medicine in the form of tablets, solution, or syrup.
  • When treating most infectious diseases, the drug is required to be taken only once a day.
  • Even against the background of possible side effects, the medicine never causes esophagitis, which very often occurs during tetracycline therapy.
  • The components of the drug can accumulate in tissues, where they will actively fight harmful microorganisms for a long period of time.

This broad-spectrum antibiotic also has special instructions for therapy.

Tetracyclines can affect the functions of the liver and kidneys and change the composition of the blood. Therefore, treatment should be carried out under the strict supervision of a doctor.

After prolonged use of the drug, diarrhea may develop. In this case, to stabilize the state of the gastrointestinal tract, light, corrective agents are used - ion exchange resins. In severe situations, fluid replacement, metronidazole or vancomycin are used.

During the therapy period, medications that can inhibit intestinal motility are not used.

According to recent studies, the drug very rarely causes side effects and is becoming increasingly popular both among patients and among doctors, who, with its help, can prescribe the most minimal courses of treatment for various infectious diseases, including their complex and severe forms.

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