How are Ingaron nasal drops used?

Release form and manufacturer

Ingaron is produced by Russia. This is a white, loose powder that must be diluted with water for injection. Available in bottles of 100,000 and 500,000 IU, 1 or 5 bottles in a cardboard package. Water for injection and pipette included.

Storage conditions

Store at a temperature of 2–8 degrees out of the reach of children. The prepared solution can be stored for 10 days in the refrigerator. Freezing ampoules with powder and the finished solution is prohibited. Do not use the drug after the expiration date!

In what form is the drug "Ingaron" produced? Reviews from experts say that this product is produced in the form of a lyophilisate, which is intended for preparing a solution for subcutaneous and intravenous administration.

The medication is white, hygroscopic, loose or porous mass.

This drug is also available in the form of nasal drops.

What components are included in the Ingaron product? Nasal drops (reviews, the price of this medicine are presented below), as well as a solution intended for intramuscular and/or subcutaneous administration, contain an active ingredient such as interferon gamma (an auxiliary component is mannitol).

The medicine goes on sale in bottles placed in cardboard packaging.

Ingredients of the drug

What does the instructions for use say about the drug "Ingaron"? The abstract indicates that this medicine is available in powder form, packaged in individual glass containers. This product requires preliminary preparation before use.

The substance that affects the patient’s body is antibodies to interferon gamma. They have quantities of 100 and 500 thousand IU per package. In a pack you can find one or five ampoules. The dosage that is suitable in an individual case is determined only by a specialist after taking into account all the indications.

pharmachologic effect

The drug is well tolerated and combines well with other drugs for the treatment of flu and colds. However, undesirable effects may occur if a person simultaneously takes antithymocyte globulin, strontium-89 chloride, theophylline, and drugs for the treatment of cancer. In any case, you need to inform your doctor about all the medications you are taking at the time of treatment.

How does the drug "Ingaron" work? Instructions for use, reviews from experts report that this is an antiviral drug, the active component of which is interferon gamma.

Human interferon gamma (recombinant) consists of amino acid residues. It is the most important pro-inflammatory cytokine, the producers of which are natural killer cells.

Human interferon gamma is able to activate the work of these cells, as well as their cytotoxicity and microbicidal activity. Thus, it causes the death of parasites.

After using this drug, the replication of viral RNA and DNA is blocked, as well as the synthesis of viral proteins and the assembly of mature viral particles. It also has a cytotoxic effect on virus-infected cells.

Currently, there is no information about drug interactions between the intranasal solution and the solution for subcutaneous and intramuscular administration. However, the patient should be sure to inform his doctor about the medications he is currently using.

About interferons

Interferons are the first factors that protect cells from damage that the body produces after contact with viruses. Today, 3 types of these substances are known; their difference is that they are recognized by special receptors on the surface of cells. Alpha or type 1 interferons are represented by several types, type 3 has 3 types, and type 2 exists in nature in the singular, it is also called immune or gamma interferon. For the human body, type 2 interferon (gamma) is of great value; scientists have found that it is the connecting bridge between innate and acquired immunity during life. This means that this interferon begins to act earlier than others at the first stage of the immune reaction, killing the foreign agent, and at the second stage it activates special cells (killer cells), providing anticancer, antiviral, and antiparasitic effects. The state of the entire human immune system depends on its quantity.

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Interferon gamma and drugs created on its basis (for example, Ingaron) are able to activate all parts of the body’s immune defense and directly kill viruses themselves.

These drugs are created to help people with weakened immunity for some reason in the fight against viral infection. Interferon gamma (Ingaron) was obtained thanks to the development of genetic engineering. Currently, it is available in different forms (injection, nasal) and can be used for preventive and therapeutic purposes, showing its effectiveness at any stage of the disease, but it will be maximum if its use is started at the first signs of infection.

Indications

1. Treatment and prevention of respiratory viral infection.
2. Prevention and treatment of seasonal influenza as part of complex therapy.
3. Prevention and comprehensive treatment of swine flu (H1N1) and H5N1 influenza. Ingaron is the only patented highly effective remedy to combat the avian influenza virus.

The Influenza Institute recommends the use of Ingaron nasal drops for prevention when visiting public transport, schools, theaters and cinemas, work offices and other places with large crowds of people, as well as during trips to areas unfavorable for morbidity.

The use of Ingaron during an outbreak, regardless of the pathogen, will help prevent the development of the disease and speed up the recovery process.

The official instructions for use indicate that Ingaron in the form of nasal drops is contraindicated in the following situations:

1. In case of individual intolerance to mannitol or interferon-gamma;
2. During pregnancy and breastfeeding;
3. In the presence of autoimmune diseases;
4. Children under 7 years of age.

Before using the drug, carefully read the instructions for use. Women of childbearing age should not plan pregnancy while taking Ingaron; it is recommended to use contraception. If pregnancy occurs, you need to stop the drug and consult a doctor.

Do you know why the medicine “Ingaron” is needed? Reviews from doctors report the following indications for this drug:

• prevention of various infectious complications in people with chronic granulomatous disease;
• treatment of chronic viral hepatitis C, as well as AIDS/HIV infection, pulmonary tuberculosis and chronic viral hepatitis B (in combination with other medications);
• treatment of herpes virus infection (including genital) and herpes zoster (as monotherapy);
• treatment of cancer in combination with other drugs, including in combination with chemotherapy (as an immunomodulator);
• treatment of chronic prostatitis in combination with other medications;
• complex treatment of urogenital chlamydia;
• treatment of human papillomavirus (anogenital warts) and prevention of recurrence of the disease;
• colds (for prevention and treatment).

  

What human conditions prohibit the use of intramuscular and subcutaneous solutions, as well as Ingaron drops? Reviews from experts report the following prohibitions:

• gestation period;
• diabetes;
• autoimmune diseases;
• individual intolerance of the patient to interferon gamma, as well as any other component of the drug.

In what situations is the medication not used in children?

The drug must not be used without a doctor's prescription. Such use can negatively affect the child’s condition and his immune system. The medication is not used for patients with diabetes. It is also not recommended for use if you have hypersensitivity or the possibility of developing an allergic reaction to interferon.

What else does the instructions for use say about the drug Ingaron? Nasal drops are not used for children under seven years of age. The abstract says that at present there is no reliable information about the consequences of such treatment.

Mode of application

Before starting treatment, you should consult your doctor and read the instructions, be careful when diluting, storing and using the drug.

1. Open the ampoule with the powder (the contents of the 100,000 IU ampoule are calculated for 5 ml of water for injection).
2. Add the contents from the ampoule with injection water to it.
3. Close the bottle with a stopper.
4. Shake the contents until completely dissolved.
5. Place into the nose with the pipette supplied with the drug by the manufacturer.

If symptoms of flu or cold appear, apply 2 drops into the nose 5 times a day for a week. First, you need to rinse your nose and blow your nose well; after instillation, massage the wings of the nose thoroughly for 1–2 minutes so that the drug spreads evenly and does not leak out into the throat.

If a person has become hypothermic or has interacted with a sick person, then as a preventive measure for flu and colds, you need to drop 2-3 drops into the nose in the morning half an hour before meals for 10 days. If there is a repeated need for prophylaxis, the drug can be used again and again. For a single contact with a sick person, a single use of Ingaron in the amount of 3 drops is sufficient for prevention.

It is forbidden to use the drug more than a single or daily dose; increased dosages increase the risk of side effects.

If an appointment was missed, you need to resume the course of treatment as soon as possible. Continue as usual. Taking a double dose is prohibited.

Instructions

For respiratory viral diseases, the most appropriate dosage form is Ingaron in nasal drops; its instructions for use contain detailed information that must be studied before using the product. The drug is effective any day from the start of administration, because it acts on the entire cascade of development of the body’s immune response - from a direct effect on the virus itself by suppressing the synthesis of its proteins and nucleic acids to activating protective factors in the blood and blocking affected cells in tissues. Ingaron is produced domestically in bottles containing 100 thousand IU powder, used in the following cases:

• as part of a complex of therapeutic measures and for the prevention of viral infections of the respiratory tract;
• for the purpose of prevention and as part of complex therapy for seasonal colds and flu;
• for preventive and therapeutic purposes against swine (H1N1) and avian influenza H5N1.

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To obtain a nasal solution, the powder from the bottle is diluted with physiological solution and distilled water in an amount of 5 ml. For prevention, Ingaron is used during outbreaks of influenza or ARVI in work or children's groups, after contact with sick family members, after hypothermia during the cold season. To do this, just drop 2-3 drops of the product into your nose in the morning half an hour before breakfast, apply every other day for 10 days, and if necessary, you can repeat it a week later. For therapeutic purposes, the drug is instilled 2 drops into each nostril 5 times a day (approximately every 3-4 hours) for 5 days (maximum week). Every time after instillation, you need to press your nostrils to the nasal septum and massage with light movements for a couple of minutes. The prepared solution can be stored in the refrigerator for no more than 10 days.

How to use the intranasal drug "Ingaron" (nasal drops)?

The price and reviews of the medication are listed below.

This drug should only be prescribed by an experienced specialist. The medication is administered subcutaneously or intramuscularly. The contents of one bottle are dissolved in 2 ml of injection water. The dosage of the drug is determined individually. As a rule, it depends on the indications.

• Therapy of chronic viral hepatitis B, chronic viral hepatitis C, as well as pulmonary tuberculosis and HIV/AIDS infections - the average daily dosage for adults is 500 00 IU. The medication is administered once a day, every day or every other day. The duration of treatment for such diseases is 1-3 months. If necessary, therapy is repeated after 30-60 days.

  

• Prevention of infectious complications in people with chronic granulomatous disease - the average daily dosage for adults is 500,000 IU. The medication is administered once a day, every day or every other day. The duration of treatment for such a disease is 5-15 injections. If necessary, therapy is repeated after 2 weeks.
• Treatment of cancer - the average daily dosage for adults is 500,000 IU. The medication is administered once a day every other day.
• Treatment of herpes virus infection, including genital, as well as urogenital chlamydia and herpes zoster - the average daily dosage for adults is 500,000 IU. The medication is administered subcutaneously once a day, every other day. The duration of treatment for such diseases is 5 injections.
• Chronic prostatitis - daily dosage is 100,000 IU. The medication is administered subcutaneously once a day, every other day. The duration of treatment for such diseases is 10 injections.
• Treatment of anogenital warts - daily dosage is 100,000 IU. The medication is administered subcutaneously once a day, one day after cryodestruction. Duration of treatment – ​​5 injections.

Reviews from experts say that the intranasal drug "Ingaron" is prescribed when the first signs of ARVI and influenza appear. The medication is dripped into each nostril 5 times a day after preliminary cleansing of the nasal passages (2 drops). This treatment should last for a week.

How to use the intranasal drug “Ingaron” (drops) for prevention? Reviews from doctors report that to prevent ARVI and influenza, as well as in case of contact with an infected person and hypothermia, the medication should be used in the amount of 2-3 drops in each nostril 30 minutes before meals. It is advisable to carry out such preventive measures every other day for 10 days.

If there was only one contact with a person infected with ARVI or influenza, then to prevent the development of the disease, it is enough to drip the drug once in the amount of 3 drops.

For greater effectiveness (so that the medication is evenly distributed in the nasal cavity), after instilling the medicine, it is necessary to massage the wings of the nose.

Analogs

How much does it cost and what can replace a drug like Ingaron? We will present the price, reviews and analogues of this medication right now.

If the mentioned product is not available in the pharmacy, it can be replaced with one of the listed products: “Laifferon”, “Alfarona”, “Avonex”, “Genferon”, “Viferon”, “Interferon”.

As for the price, the drug "Ingaron" is quite high. The cost of this medicine depends on the volume and quantity in one package. Lyophilisate for intranasal use, as well as for subcutaneous and intramuscular administration, 500,000 IU can be purchased for 1080-1200 rubles (one bottle).

If you need several injections, then bottles of 5 pieces (100,000 IU each) are sold for 1,700-1,800 rubles.

As for the intranasal product, its price is slightly lower and amounts to 700-800 rubles per bottle.

Analogues are those medications that can replace Ingaron. Ingaron has no structural analogues of the active substance (interferon-gamma), but interferon inducers, umifenovirs and drugs containing interferon-alpha are widely used as antiviral agents, along with interferon-gamma:

• Grippferon (nasal drops);
• Viferon:
• Human leukocyte interleukin (solution dripped into the nose);
• Amiksin:
• Cycloferon;
• Alfaron (nasal drops);
• Anaferon, etc.

General characteristics of the medicine

The drug Ingaron, as evidenced by the instructions for use, is produced in Russia by the domestic pharmacological company Pharmaklon.

This drug has been produced for a long time, but it has become especially popular since 2009. This is due to the fact that a swine flu pandemic occurred in the country.

Ingaron is produced in the form of a loose white powder intended for dilution with water. One bottle of Ingaron contains 100,000 or 500,000 IU. The packaging of the drug contains 1 or 5 similar bottles. In addition, the release of each package is accompanied by the inclusion of water for injection and a pipette.

Before you start using the medicine, you must read the information contained in the instructions for use. In particular, this applies to the storage conditions of the drug. It must be stored out of the reach of small children. The temperature should be from 2 to 8°C. The prepared solution can be stored in the refrigerator for no more than 10 days. Freezing the drug is prohibited.

If this drug is unavailable for various reasons, treatment can be carried out using its analogues. Among the drugs that can replace Ingaron are Viferon, nasal drops Grippferon, Amiksin, Anaferon, Cycloferon.

All of the listed analogues and some other drugs that can be found on pharmacy shelves are not complete substitutes for interferon gamma, the basis of Ingaron. These are interferon inducer drugs, drugs containing alpha interferons and umiferons.

The use of the drug Ingaron is perfectly combined with the use of other medications intended for therapeutic effects in cases of flu and colds. Each body is individual and has different reactions to drugs, so sometimes side effects may occur. In particular, this may be due to the intake of antithymocyte globulin, strontium-89 chloride, theophylline and some drugs intended for the treatment of cancer. Therefore, when a doctor prescribes Ingaron, the patient must notify his attending physician about all medications currently taken.

Numerous reviews from patients who have experienced the effects of Ingaron indicate that the drug is indeed an effective remedy in the fight against infection. Ingaron can be used not only as a treatment, but also for prevention during colds.

Price and analogues of the medicine

There are quite a lot of reviews about the drug "Ingaron". Most of them are positive. Patients report that this antiviral medication is very effective. It perfectly helps with herpetic rashes, as well as with other more serious diseases.

Along with the solution for intramuscular or subcutaneous administration, the intranasal form is very popular among patients.

Just a few days of active treatment with this drug can get rid of all signs of flu and colds. It should also be noted that many people often use this solution for preventive purposes. Instilling it into the nose helps prevent infection with colds, especially if a healthy person has had direct contact with a sick person.

The cost of the drug varies depending on the region of the country and pharmacy.

• The average price for 1 bottle of 100,000 IU is 300 rubles.
• The average price for 5 bottles of 100,000 IU is 1,600 rubles.
• The average price for 1 bottle is 500,000 IU – 1,000 rubles.
• The average price for 5 bottles of 500,000 IU is 4,700 rubles.

Adverse reactions

Do adverse reactions occur after using the drug "Ingaron"? Reviews from doctors report that after intramuscular or subcutaneous administration, patients may experience redness of the skin and mild pain at the injection site.

It should also be noted that there are reviews of overdose with this drug. When using Ingaron in a dose exceeding 1,000,000 IU, people experience joint pain, headaches, weakness, and increased body temperature.

If the listed flu-like symptoms are mild, they do not require special treatment. If the patient’s condition noticeably worsens, then you should take a Paracetamol tablet.

As for the intranasal use of the drug, it never causes unwanted reactions.