Sprays and drops with a vasoconstrictor effect are very popular among the population. They help restore normal nasal breathing and relieve swelling of the mucous surface. One of the newest drugs from this group is Lazolvan Rino. The instructions describe in detail the composition, mechanism of action and recommendations for prescribing the medication. Let us consider in more detail the features of its use, the possibility of its use during pregnancy, contraindications and analogues.
Description of the product
A huge number of special medications are currently being produced to combat runny nose and nasal congestion. On the positive side, drops and sprays based on xylometazoline, oxymetazoline and naphazoline have proven themselves. The newest drugs with a vasoconstrictor effect include Lazolvan Rino. The price of the Italian-made drug is slightly higher than its domestic counterparts and ranges from 240-330 rubles.
"Lazolvan Rino" has a long-term therapeutic effect. Normal nasal breathing persists for 8-10 hours after use. It is not recommended to use the medication without a specialist’s prescription due to the presence of numerous contraindications.
pharmachologic effect
Tramazolin is an alpha-adrenergic agonist . The medication has a vasoconstrictive, anti-congestive effect.
The active substance helps to narrow the lumen of blood vessels, which reduces the severity of swelling when applied to the mucous membranes of the nose. The medication makes nasal breathing easier for a long time and restores the patency of the nasal passages during a runny nose . The effect develops 5 minutes after applying the spray and lasts 8-10 hours.
Compound
The drug contains the newest active ingredient from the group of alpha-adrenergic agonists - tramazoline hydrochloride. The component has a pronounced vasoconstrictor effect. It is used in the treatment of pathologies of the nasal cavity to reduce swelling of the mucous surface by stimulating adrenergic receptors.
Excipients: benzalkonium chloride, levomenthol, racemic camphor, calcium chloride dehydrate, glycerol, magnesium chloride hexahydrate, eucalyptol, purified water, sodium bicarbonate and sodium hydroxide.
The manufacturer reports that the drug has not been studied in humans. The effect of the active ingredient has been studied in animals. During the tests, it was found that tramazolin is absorbed by 50-80% after use. The maximum concentration of the component was found in the liver, and traces of metabolites were recorded in all organs.
Indications for use
Constriction of blood vessels in the nasal cavity is the main task of the drug Lazolvan Rino. The spray, according to reviews, effectively eliminates a runny nose and restores nasal breathing. Similar symptoms are usually encountered with viral and bacterial infections and colds. However, without the advice of a doctor who can draw up a treatment regimen, it is not recommended to use the medicine for the nose.
The instructions for using Lazolvan Rino spray allow it to be used in the following cases:
- difficulty breathing through the nose due to an acute respiratory viral disease;
- rhinitis of bacterial etiology;
- chronic rhinitis;
- sinusitis (sinusitis, ethmoiditis, frontal sinusitis);
- otitis media;
- rhinitis of allergic origin.
The use of a vasoconstrictor drug based on tramazoline for otitis is justified by the fact that the active component facilitates the outflow of mucous secretions from the nasal sinuses and thereby reduces the pressure in the auditory (Eustachian) tube.
Can it be prescribed to pregnant women?
Women during pregnancy often encounter such an unpleasant phenomenon as a hormonal runny nose. This is due to an increase in the level of female hormones and increased blood flow. Against this background, swelling of the nasal mucosa occurs and, as a result, normal breathing becomes difficult. This condition is dangerous for both the expectant mother and the fetus.
Is it possible to use drops with a vasoconstrictor effect to alleviate the condition? In some cases, the doctor can choose the appropriate remedy. In this case, the dosage must be adjusted. However, not all drugs in this category are suitable for pregnant women.
"Lazolvan Rino" is used quite often during pregnancy. This is one of the few remedies that does not harm the developing fetus and does not affect the course of pregnancy itself. However, in the first trimester, the manufacturer recommends refraining from using the vasoconstrictor drug.
Starting from the second trimester, when the formation of the main systems and organs of the fetus has already occurred, you can safely use Lazolvan Rino spray to treat a runny nose. During pregnancy, the attending physician usually recommends reducing the daily dosage of the drug.
Lazolvan Rino during pregnancy and lactation
Quite a long experience of prescribing the medication to pregnant women has not revealed a negative effect on the course of pregnancy and fetal development. There is no data on the absolute safety of using the spray during lactation.
The manufacturer does not recommend the use of the drug in the first trimester of pregnancy. When breastfeeding and during late pregnancy (2/3 of pregnancy), the medication can be prescribed according to the decision of the treating doctor.
Mode of application
Thanks to the presence of a special nozzle with a dispenser, using the spray is quite simple. First of all, you need to remove the protective cap and press the dispenser several times, releasing the medicine into the air. This is necessary for the appearance of a full-fledged aerosol cloud. You will also need to clean the nasal passages for better penetration of the active ingredients.
After all the preparatory manipulations, you should insert the tip of the bottle into one nasal passage and press the sprayer (1-2 times). After removing the tip, take a deep breath through your nose. Then repeat the action with the other nasal passage.
The Italian pharmaceutical spray is characterized by patient reviews as an effective medicine that, if the dosage and doctor’s recommendations are followed, helps to quickly cope with viral and bacterial diseases of the nasal sinuses, eliminating swelling of the mucous membrane.
Lazolvan Rino, instructions for use (Method and dosage)
In pediatric practice (from 6 years old) and adults, the spray is prescribed according to the standard regimen: 1 injection into each nasal passage (no more than 4 injections can be performed per day). Uncontrolled use of the medication is unacceptable. The medicine can be used for no more than 5-7 days.
Instructions for use of Lazolvan Rino also include rules for using a special dosing device:
- Remove the protective cap from the bottle.
- Make several injections into the air until a stable aerosol cloud forms. The device is now ready for full use.
- Clean the nasal passages and insert the tip into the nose, then spray. Repeat for the second nasal passage. Inhale normally through your nose after removing the special tip.
- Place the protective cap on the bottle.
- The tip must be cleaned after each use.
How long can I use the drug?
Experts strongly advise avoiding long-term use of vasoconstrictor drugs for the nasal cavity. As is known, they can cause addiction due to the fact that the receptors cease to independently maintain blood vessels in tone, shifting this “task” to the active components of the drug. Spray, or, as some patients say, Lazolvan Rino drops, is also not recommended for use for longer than 7 days.
In addition to the addictive effect, the drug, with prolonged use, significantly worsens the condition of the mucous membrane, causing increased dryness and a tingling sensation. Nosebleeds occur very often.
During the day, the procedure for injecting the medication can be repeated no more than 4 times. The spray begins to act within a few minutes, bringing relief and restoring freedom of nasal breathing for about 8 hours.
"Lazolvan Rino" for children
Children suffer from nasal congestion much more often than adults. Therefore, vasoconstrictor drops and sprays are usually present in the first aid kit of every home where there is a child. In addition to the fact that such drugs will help the baby breathe freely through the nose, they will also significantly reduce the amount of secretion released. Is it possible to use Lazolvan Rino for these purposes? The instructions warn about the age limit regarding the use of this medication.
For the treatment of children, the medicine is used only if the child is already 6 years old. It should be taken into account that adjustments to the daily dose and treatment regimen may be necessary. Therefore, it is imperative to consult an ENT specialist or pediatrician before starting treatment with Lazolvan Rino. For younger children, drops based on phenylephrine should be used.
special instructions
If there is no positive dynamics in the first week of treatment, it is recommended to consult a doctor to consider stopping therapy or continuing treatment. Long-term uncontrolled use of vasoconstrictor nasal agents can provoke the development of atrophy of the nasal mucosa, the formation of a chronic inflammatory process, or cause nasal congestion. Tramazolin solution should not come into contact with the eyes.
Special studies on the possible effect of the drug on a person’s ability to operate complex machines, mechanisms and drive vehicles have not been conducted. Considering that the manufacturer has announced such undesirable reactions as dizziness, drowsiness, hallucinations, fatigue, sedation , it is recommended to refrain from driving during treatment with Lazolvan Rino.
Contraindications
Despite the local use of a vasoconstrictor spray, you need to familiarize yourself with the list of contraindications before starting therapy. This will help prevent side effects. "Lazolvan Rino" has the following contraindications for use:
- hypersensitivity to benzalkonium hydrochloride and tramazoline;
- angle-closure glaucoma;
- atrophic rhinitis (use of the medication is fraught with irreversible damage to the mucous membrane);
- surgical interventions performed through the nasal cavity;
- first trimester of pregnancy;
- age up to 6 years.
There is also a list of relative contraindications, in which the use of the drug is allowed only as prescribed by a doctor and under his strict supervision. The spray is used with restrictions for arterial hypertension, pathologies of the cardiovascular system, pheochromocytoma, porphyria, prostate hypertrophy. During therapy with MAO inhibitors or taking tricyclic antidepressants, the instructions recommend discussing the possibility of using Lazolvan Rino with your doctor.
Overdose
The first signs of an overdose are a rapid heartbeat and a rise in blood pressure, followed by reflex bradycardia , shock, and a possible decrease in overall body temperature. Similar to other alpha-sympathomimetics, the clinical symptoms of poisoning are unclear, because phases of depression and stimulation of the central nervous system and cardiovascular system successively replace each other.
In children convulsions , coma , respiratory depression , and the development of bradycardia . Signs of a stimulating effect on the functioning of the central nervous system are hallucinations, agitation, anxiety and the development of convulsive syndrome. When the nervous system is depressed, lethargy, a decrease in overall body temperature, and increased drowsiness are noted.
Side effects
By observing the dosage and not exceeding the recommended duration of treatment with the medication, it is almost impossible to develop any side effects. Symptoms such as dizziness, headache, increased blood pressure, and a feeling of anxiety usually indicate that the dose of tramazolin has been significantly exceeded.
If the patient has serious problems with the digestive system, nausea may occur after using Lazolvan Rino.
Reviews from patients indicate that sometimes allergic reactions occur: itching and burning in the nasal cavity, dry mucous membranes, rashes. More rare side effects include insomnia, hallucinations, tachycardia, respiratory depression, and drowsiness. If you use the spray for more than 7 days, periodic nosebleeds appear.
It is necessary to stop using the medication if there is no improvement within a few days after starting therapy. If longer treatment with the product is required, it is recommended to take a break for at least a few days after 7 days of using the spray.
"Lazolvan Rino": analogues
If necessary, you can select other vasoconstrictor drugs for the nose. Medicines such as Otrivin, Grippostad-Rino, Farmazolin, Nazol, Polidexa will be no less effective. For the youngest patients, Nazivin and Vibrocil drops are suitable.
Adrianol drops contain a complex of powerful active ingredients - phenylephrine and tramazoline. They can be used as a structural substitute for the drug Lazolvan Rino. The price of the analogue is 130-150 rubles. Please note that this medication contains ethanol.
Lazorin nasal spray also contains tramazoline hydrochloride as an active substance and has a pronounced vasoconstrictor effect for rhinitis and sinusitis.
