Ventolin Nebula solution for inhalation 2.5 mg/2.5 ml No. 20

Treatment of bronchial asthma and other respiratory diseases that are accompanied by bronchospasms requires a responsible approach. A drug that can relieve airway obstruction must act not only effectively, but also quickly. Ventolin for inhalation has these properties.

The drug is characterized by an anti-asthmatic effect, removing the reactivity of bronchial smooth muscles. Ventolin is a modern medicine, but it should not be used without a prescription from a specialist. The dosage, frequency of use and duration of treatment with the drug are determined by the attending physician.

Instructions for use of Ventolin

Ventolin inhalation solution should not be swallowed or administered as an injection.
It is used using a nebulizer - a small inhaler that delivers the drug into the respiratory tract using an endotracheal tube. When working with a nebulizer, a special mask is used. The room for the procedure must be well ventilated. Ventolin spray is administered through the mouth during inhalation, the amount of medication is controlled by a dispenser. One injection of the drug is considered one dose and contains 100 mcg of the active substance - Salbutamol. Before using the aerosol, you need to make sure that the dosing device works: remove the cap, shake the can slightly, and perform a test spray into the air.

Composition and release form

The drug is sold in the form of an inhalation solution, aerosol, tablets and syrup. Its active substance is salbutamol sulfate, one of the selective beta-adrenergic receptor agonists. The aerosol is produced in metal cans with a metering valve and a spray nozzle. The solution is produced in nebulas - polyethylene ampoules welded together in the form of a strip. Study the characteristics of different forms of release of the drug:

Pharmacological properties

The drug stimulates beta-adrenergic receptors of the bronchi, which causes expansion of different parts of the bronchial tree, relieving bronchospasm. It reduces airway resistance, increases mucus secretion, mucociliary clearance, and dilates the coronary arteries. Most of the substance remains in the oropharynx, only 10-12% reaches the distal respiratory sections. The effect of the drug occurs within 5 minutes from the moment of use and lasts about 5 hours. The active substance is metabolized by the liver into phenolic sulfate and disposed of in the urine.

Indications for use

The medicine is prescribed for short-term (4-6 hours) dilation of the bronchi and relief of asthma attacks due to airway obstruction. As a prophylactic agent, a bronchodilator is taken shortly before contact with allergenic substances, before physical activity. As a component of complex therapy, the medication is prescribed for:

• bronchial asthma;
• obstructive chronic pulmonary disease with reversible bronchial obstruction.

Prohibitions

"Ventolin Nebula", instructions, reviews and recommendations for use of which are now becoming known to us, has a number of prohibitions. And in this regard, buyers remain satisfied. The drug itself does not pose any danger; there simply have not been enough studies done to confirm the complete safety of the drug.

Children under one and a half years should not take it. In addition, numerous reviews state that Ventolin should not be used by people with hypersensitivity, individual intolerance to some of the components included in the drug, as well as patients with an increased risk of fatal allergic reactions.

This concludes the list of prohibitions

Generally speaking, pregnant and lactating women should take Ventolin, reviews of which are often encouraging, with caution. In principle, as you can already see, this drug is almost not prohibited for children

And this fact undoubtedly pleases patients and their parents.

Contraindications

The main contraindication to the use of this drug for the treatment of bronchial asthma is a person’s sensitivity to the components that make up the drug. Pregnant women with a risk of premature birth or miscarriage are not recommended to use this medicine.
Also, the drug is not prescribed to children under two years of age. Treatment of bronchial asthma using this drug should be approached with extreme caution if the patient has the following diseases:

• myocarditis;
• heart defects;
• glaucoma;
• epilepsy;
• aortic stenosis;
• liver failure and kidney problems;
• arterial hypertension.

The instructions for this drug indicate that in some cases, pregnant women and mothers who are breastfeeding have the opportunity to be treated with this drug. This possibility is allowed only in cases where the effect on the patient’s health significantly exceeds the risk that may arise for the child when using this drug for treatment.

This warning is mainly due to the fact that studies have shown that when taking this medicine in nebulas, its components can have a negative effect on the pregnant fetus. As a result, the child may have a risk of pathology in the form of a cleft palate and congenital deformities of the limbs.

However, as of now, experts have not been able to identify the existence of a cause-and-effect relationship between taking this pharmacological agent and pathologies that occur in the fetus. In the studies, the subjects took completely different medications. There is also no information about the effect of salbutamol, which acts as the main compound in Ventolin, on a newborn. However, to avoid risk, doctors do not prescribe this drug to pregnant women or mothers who are breastfeeding.

Ventolin for inhalation dosage instructions

The instructions for the drug Ventolin in the form of nebulas for inhalation indicate that it can be used for treatment in diluted form. The attending physician determines the method of administration of the medicine, as well as the dosage. When making these important decisions, he takes into account the age of the patient, as well as his state of health.

Solution

For adult patients and children over 12 years of age, this drug in nebulas is prescribed in the following dosages:

• in a diluted form. 1 ml of Ventolin must be mixed with a physical solution. The output should be 2-2.5 ml of the finished product. Then it should be placed in a nebulizer, and then inhaled. The procedure should last until the formation of aerosol stops;
• in its purest form. The drug is placed in the nebulizer in an amount of 2 ml. Then inhalation is carried out. Usually the duration of the procedure does not exceed 5 minutes;
• For young patients aged 2 to 12 years, this drug is prescribed in diluted form. The drug in an amount of 0.5 ml is diluted in physical solution in order to obtain a ready-to-use product with a volume of 2-2.5 ml. A nebulizer is used for inhalation. Sometimes, as prescribed by a doctor in cases of severe development of bronchial asthma, the dose of the drug can be increased to 1 ml;
• the number of procedures is prescribed by the doctor. After 20 minutes, repeated inhalations can be carried out, but their total number should not exceed 4 times within 24 hours.

Aerosol

For children over 12 years of age and adults, the medicine is prescribed in the following dosages:

• for acute attacks of bronchospasm, the patient takes 100-200 mg of medication or 1-2 injections;
• as a preventive measure against attacks of acute bronchospasm that occur as a result of the entry into the body of a substance that is an allergen, and during physical stress, the patient should take the medicine in a dosage of 200 mg or 2 injections;
• For therapy aimed at supporting the patient’s condition, which is prescribed by the attending physician for a long period, as one of the measures, the patient is prescribed 100 mg of medication or 1 injection.

Children from 2 to 12 years old

• in the presence of acute attacks of bronchospasm, the medicine is taken in the amount of 100 mg or 1 injection;
• in order to prevent bronchospasm attacks, 100 mg of medication or one injection is taken 15 minutes before exposure to provoking factors on the body;
• in a dosage of 100 mg or one injection, the medicine is taken to support the patient’s condition. It is impossible to exceed the intake of the drug 4 times during the day.

General instructions

"Ventolin" is intended for spraying only. An increased need for beta-2 adrenergic receptor agonists may indicate signs of worsening asthma. In this situation, the treatment regimen should be re-evaluated while simultaneously considering the advisability of prescribing combined treatment with glucocorticosteroids. Since an overdose of Ventolin (the instructions confirm this information) poses a risk of developing serious side effects, the frequency of use and dose can be increased only on the recommendation of a specialist. For patients who have difficulty synchronizing inhalation while using a pressurized aerosol can, a spacer may be used. The instructions for children under 5 years of age included with Ventolin Nebula recommend administering the medication using a pediatric spacer device with a face mask.

How does the drug interact with other medications?

The simultaneous use of Ventalin with non-selective adrenergic blockers, for example, with Propranolol, is not recommended.

The use of Ventolin in combination with anticholinergic drugs increases intraocular pressure.

The hypokalemic effect of the drug is enhanced by the use of diuretics and glucocorticosteroids.

It is important to consider that the positive effect is achieved by strictly following the instructions for using Ventolin for inhalation. Reviews about the drug are mostly laudatory; most people who have used the drug note its good tolerability and effectiveness in the treatment of bronchodilator conditions. This inhalation product is not intended for self-medication due to its systemic effect on the body and the risk of side effects.

Olga Rogozhkina,

Instructions for use

Ventolin is used exclusively for inhalation, during which the medicine is inhaled through the mouth. For young children, the medication is administered using a special device (called a spacer), which has a face mask. When the inhaler is used for the first time or the last use of the medicine was more than five days ago, it is recommended to remove the cap, shake the can and spray the medicine into the air 2 times.

For inhalation you need:

1. Remove the cap.
2. Check all parts of the can and mouthpiece to ensure there are no foreign objects.
3. Shake the inhaler (this will mix the contents evenly).
4. Holding the balloon vertically with the bottom up, invite the child to exhale as much as possible.
5. Place the mouthpiece in the small patient's mouth and tell the child to cover it with his lips, but not touch it with his teeth.
6. While taking a deep breath, press on the top of the can so that one dose of the medicine enters the respiratory tract.
7. Tell your child to hold his breath.
8. Remove the mouthpiece from your mouth.
9. If another dose is required, repeat all steps after 30 seconds.
10. Close the tip with a cap.

Description of the drug

The medicine is produced by British. It is available from pharmacies with a prescription.

The drug is a clear solution for oral or inhalation use, which can be completely transparent or pale yellow in color. Ventolin nebula in the photo:

It is widely used to treat a large number of respiratory diseases, as it is one of the selective β-2-adrenergic receptor antagonists.

In other words

It acts directly on a special group of nerve endings (receptors) of the bronchial muscles and helps to relax it, expand the lumen of the airways and increase the volume of inhaled air.

If the recommended doses indicated in the annotation are observed, it has almost no negative effect on the β-1-adrenergic receptors of the heart muscle.

Ventolin is also used for coughs, especially for dry coughs, since it can stimulate the functioning of the bronchial glands and activate the removal of phlegm.

Therefore, a cough is often observed after Ventolin, since the increased amount of mucus irritates the receptors, as a result of which it begins to be removed from the bronchi.

At the same time, many patients are concerned with the question “Is Ventolin hormonal or not?” People's fears are justified, but unfounded, since it is not one of the products containing any hormones.

The instructions recommend using the product as a solution for inhalation therapy. After the procedure, no more than 10–20% of the injected volume reaches the bronchi and lungs, while the remainder of the fine aerosol particles settles on the surface of the mucous membranes of the oral and nasal cavities.

After which it is swallowed, absorbed into the systemic bloodstream, transformed in the liver and excreted by the kidneys, as well as in small amounts with feces.

The particles that penetrate into the lower parts of the respiratory organs and exert their pharmacological effect there are absorbed into the bloodstream unchanged, destroyed in the liver and excreted by the kidneys. The positive effect appears literally after 5 minutes and lasts up to 6 hours.

How to take it correctly

The use of the medication for intravenous or intramuscular administration is strictly prohibited; in addition, it cannot be taken orally. Before use, you should carefully study the instructions and consult your doctor.

The solution is used for inhalation using a special device - a nebulizer or other devices that generate steam. Treatment should be carried out under the supervision of medical staff. For a therapy session not exceeding 10 minutes, it is not necessary to dilute the Ventolin solution; it can be used unchanged. If one session takes more than 10 minutes, the substance is diluted with 0.9% sodium chloride.

One strip is separated from the pack, the rest are returned to the storage location, in accordance with the rules specified in the instructions. The contents of the ampoule are placed in a nebulizer capsule. After this, the installation is used strictly according to the established rules. The steam released is considered harmful to the visual organs, so you must ensure that the mask is pressed tightly to your mouth.

If the solution needs to be mixed with another composition, both substances are poured into the installation capsule and shaken thoroughly. After the procedure, the residues must be removed and the capsule must be rinsed thoroughly. In case of acute lesions of the pulmonary system, the use of Ventolin is carried out under the supervision of medical personnel. It is also advisable to prescribe oxygen therapy to prevent the development of hypoxia.

You can also buy analogues of the medication in pharmacies. Among them: Nebutamol, Ventolin Nebula, Salbutamol-Neo, Onbrez Breezhaler and other drugs.

Rules for inhalation with Ventolin

Characteristics of the solution

The main active ingredient of this medication is salbutamol; in pharmacies you can find a solution intended for inhalation with a concentration of 0.1%. This medicine is used to relieve asthma, prevent complications and provide symptomatic therapy for common diseases of the respiratory system. These include chronic obstructive pulmonary disease and bronchial asthma.

Standard dosages of Ventolin

In all cases, before using the drug in adults and children, medical consultation is required. In order for a parent to be able to correctly organize inhalations for a child at home, certain knowledge is needed. For short-term therapy in adults, dilution of the solution is not required. The 1% solution contained in the package is completely ready for use. Each vial, or nebula, contains 2 milliliters (2.5 milligrams) of solution

Adults are advised to use the undiluted drug with caution, observing the reaction of their body.

Dosage for long-term use of Ventolin

If one session lasts longer than a quarter of an hour or the therapy drags on for a long time, it is customary to dilute Ventolin by adding other liquids to it. For this purpose, a pharmaceutical saline solution with a concentration of 0.9% is best suited. Initially, a dosage of up to 2.5 milligrams is traditionally used (this volume also includes at least 1 milliliter of saline), the procedure is carried out no more than 4 times a day, the pause between inhalations should be at least 6 hours. This treatment works well for laryngitis, bronchitis and cough of various etiologies. If this treatment turns out to be ineffective, the dose can be increased to 5 milligrams. As practice shows, under the supervision of doctors in a hospital setting, an increase in the daily dose to 40 milligrams can be prescribed - this happens in case of severe diseases of the respiratory system.

Children's dose of Ventolin

When it comes to treating young children, the dosage of any drug should be determined by a doctor. The pediatrician handles this task. Experts often advise starting inhalations for children with half the contents of one nebula with the addition of 1 milliliter of saline solution. If a parent does not know how to dilute Ventolin for inhalation for a child, it is better to consult a doctor for advice.

Ventolin for children under 2 years of age

When treating a child under 2 years of age, the drug is used exclusively in diluted form. You can take half a milliliter of Ventolin solution and add enough saline to get 2.5 milliliters of liquid. If the child has serious breathing problems, then under the supervision of a doctor, increase the dose to 1 milliliter. How many procedures a particular child needs is up to the attending physician to decide. A break of at least 20 minutes is required between inhalations. It is known that medicine does not have reliable knowledge about the effectiveness of Ventolin for children under one and a half years old.

How to inhale with Ventolin?

Generally accepted rules state that the steam procedure should be carried out an hour and a half after eating. First, remove the nebula from the bag and shake the liquid. According to the instructions, you need to open the bottle, add saline solution if necessary, and install it in the working part of the nebulizer. After activating the device, perform inhalation. Relief from pathologies of the bronchi and lungs is achieved by inhaling vapors through the mouth. In this case, a special mask is used. The most effective in this case will be a mouthpiece called an endotracheal tube. To obtain a therapeutic effect, you should not inhale the vapor deeply; you can breathe normally.

Ventolin for inhalation: an effective bronchodilator drug suitable for children

Contraindications for use and side effects

There are not so many absolute contraindications for use, as stated in the instructions. These include:

• intolerance to any of the components of the drug,
• children up to 18 months,
• pregnancy with threat of miscarriage or premature birth.

But there are quite a lot of situations when Ventolin needs to be used with caution . This:

• cardiac ischemia,
• myocarditis,
• Congenital heart defect,
• tachyarrhythmia,
• aortic stenosis,
• thyrotoxicosis,
• glaucoma,
• diabetes mellitus in the stage of decompensation,
• arterial hypertension,
• renal and liver failure
• epilepsy,
• children under 2 years of age,
• period of pregnancy and breastfeeding

If we talk about childhood, pregnancy and during breastfeeding, the drug can be prescribed by a doctor in cases where the risk of harm is less than the benefits of its use. But only a doctor can determine this. Ventolin can also have side effects . The most common are the following:

• trembling of skeletal muscles,
• muscle spasm,
• headache and dizziness,
• tachycardia,
• irritation of the mucous membrane of the larynx and mouth,
• various allergic reactions, including paradoxical bronchospasm,
• addiction with long-term use and some others.

other side effects may occur , such as vomiting, agitation, nausea, low blood pressure, and in rare cases, hallucinations may occur. To prevent all this from happening, please read the instructions carefully before using the drug. You should also study the instructions for using the nebulizer. And you should not use Ventolin without a doctor’s prescription.

Instructions. Method and dosage for adults

The instructions for use of Ventolin recommend inhaling its vapors through a nebulizer or taking it orally according to the regimen developed by the doctor.

For asthma, the medicine is taken according to a special step-by-step program. The effectiveness of therapy is constantly monitored by performing specific pulmonary function tests and assessing the patient’s clinical condition.

If the patient is forced to take the medication more often than prescribed, and there is a need to review the prescribed course.

Thus, the reasons for urgently contacting a doctor are:

1. reducing the duration of relief after an inhalation therapy session;
2. decrease in the severity of the therapeutic effect after administration of the recommended dose.

Attention! It is unacceptable to increase the dosage or frequency of taking the medicine without permission!

Adults are advised to administer the contents of one ampoule 4 times a day. If necessary, the therapeutic dose can be increased to 5 mg per manipulation.

It is extremely rare for severe obstruction to increase the daily dose to 40 mg. But the use of such large dosages is carried out exclusively in a hospital setting under the supervision of doctors.

Inhalation therapy sessions are carried out as follows:

1

Ventilate the room well and leave the window open. Prepare the inhaler and open the nebula package, shake it. 2

Holding the bottom of the ampoule with one hand and the top with the other, turn it and open it. 3 Pour all its contents into the device chamber. 4

Completely assemble the apparatus, put on the face mask or install the mouthpiece. It is better for adults to use a special mouthpiece attachment, as this ensures maximum penetration of the active ingredients to the destination. For children and elderly people who are not able to fully control the breathing process, a face mask is more suitable.

5

The duration of the procedure is determined separately by the doctor. In the absence of special instructions, it is carried out until the formation of aerosol stops, which is approximately 10 minutes. 6 Clean the components of the device from any remaining liquid.

The manipulation should be performed no earlier than an hour after eating or smoking. After it, you should not eat, talk, go outside or smoke for an hour and a half.

Also, the medication can be taken orally, one or two pieces three times a day. Sometimes the dose is increased to 8 milligrams with four doses.

How to dilute Ventolin for a nebulizer: instructions

It is often practiced to administer an undiluted solution. However, if long procedures (more than 10 minutes) are required, it may be necessary to prepare a diluted solution.

The contents of the ampoule must be properly diluted with saline solution. The doctor determines the ratio of saline solution and Ventolin for each patient personally.

Traditionally, the solution is prepared by introducing Ventolin into the nebulizer in the prescribed amount and bringing the volume of liquid in the device chamber to 2–2.5 ml. Sometimes only 0.5 ml is used, which should be diluted with a large volume of saline solution.

If the doctor prescribes the administration of an undiluted solution, then how to do the procedure should be clarified with him. Perhaps the patient will be prescribed 4 ampoules in one session.

Pharmacodynamics and pharmacokinetics

The drug is used to prevent bronchospasms

.
It is a bronchodilator
, or more precisely,
a selective beta-2-adrenergic agonist
.
It increases the vital capacity of the lungs and mucociliary clearance
, activates the work
of the ciliated epithelium
, improves mucus secretion, dilates
the coronary arteries
, reduces potassium content, acts as a
hyperglycemic
and
lipolytic agent
, affects
glycogenolysis
and insulin secretion, and increases the risk of occurrence.

The medicine acts quite quickly, almost 5 minutes after application (maximum - after 30-90 minutes). The duration of the effect is about 5 hours.

10-20% of salbutamol after use ends up in the lower respiratory tract. They are absorbed into the lung tissue and blood, but are not broken down. The remaining amount of the active substance is retained in the inhaler or in the oropharynx, after which it is swallowed and actively broken down when passing through the liver and converted into phenolic sulfate

.

The degree of binding to plasma proteins is approximately 10%.

Salbutamol entering the blood is broken down within 72 hours in the liver and is excreted mainly in the urine in the form of phenolic sulfate

or in an unchanged state. A small part is excreted in the feces.

Additionally

Severe asthma requires constant medical monitoring due to the possibility of death. Patients with severe asthma have persistent symptoms and frequent exacerbations with limited physical ability and a peak expiratory flow (PEF) value less than 60% of normal and a variability greater than 30%, and the value does not return to normal after use of a bronchodilator. Such patients require high doses of inhaled (more than 1 mg/day beclomethasone dipropionate) or oral corticosteroids

Patients receiving treatment with Ventolin respiratory solution at home should be warned that if the usual relief has become weaker or the duration of action of the drug has become shorter, they should in no case independently increase the dose or frequency of administration of the drug without consulting with their doctor. Ventolin respiratory the solution should be used with caution in patients who have already taken high doses of other sympathomimetics. Isolated cases of acute angle-closure glaucoma have been reported in patients receiving a combination of Ventolin respiratory solution and ipatropium bromide using a nebulizer. Given this fact, caution should be exercised when using salbutamol and anticholinergics via nebulizer simultaneously. Patients should receive appropriate instructions for proper use. Like other beta-adrenergic agonists, Ventolin respiratory solution may cause reversible metabolic changes, such as an increase in blood glucose concentrations

Patients with diabetes may develop decompensation, and in some cases, the development of ketoacidosis. Concomitant use of glucocorticosteroids may enhance this effect. Very rarely, the occurrence of lactic acidosis associated with the use of Ventolin respiratory solution in patients with exacerbation of bronchial asthma has been reported. Increased lactate levels lead to shortness of breath and compensatory hyperventilation, which may be misinterpreted as symptoms of improperly treated asthma. This may lead to inappropriate intensification of treatment with rapidly acting beta-agonists, so monitoring for increased serum lactate and therefore metabolic acidosis is recommended. Inhaled drugs may cause paradoxical bronchospasm. Paradoxical bronchospasm must be immediately relieved using another alternative dosage form or another fast-acting inhaled bronchodilator. You should immediately stop using the drug Ventolin respiratory solution, assess the patient's condition, conduct the necessary examination and prescribe alternative treatment.

Beneficial features

The drug Ventolin has a bronchodilator effect on the body, allowing a person to breathe more freely and absorb a large volume of air. It should be used only in consultation with a doctor.

The use of Ventolin solution using a special device - a nebulizer, allows you to quickly deliver active substances to the affected organs. Through it, the intake is safe and the risk of developing unpleasant consequences is reduced, since the steam enters directly into the respiratory organs.

During an attack, it is better to go through the procedure slowly (using a nebulizer). This is due to the patient’s inability to take deep breaths and hold their breath at this moment. All this affects the beneficial properties that a person receives when taking the medication in the form of an aerosol. The method of application using a nebulizer will provide quick and complete relief from suffocation, stopping the attack.

Can it be given to children?

Ventolin is used in pediatric practice, but it is very important that at the time of treatment the child is at least 2 years old, although there are cases when the medicine begins to be prescribed from 18 months. It's all about the effect of salbutamol on the nervous and cardiovascular systems of children

So, after inhalation, a child may become irritable and nervous, but there will be no apparent reason for this. Tachycardia is also common after taking salbutamol.

If at 2 years old a child endures this with virtually no consequences, then at a younger age it can have negative consequences for the cardiovascular and nervous systems. So, with age, stuttering, nervous tics or heart problems may begin. Ventolin should not be prescribed to children if they suffer from cardiovascular diseases, since its active ingredient salbutamol can worsen the course of the disease. The drug is prescribed for a short period of time – usually three days. At the same time, pediatricians recommend inhalations before 6 pm so that the child falls asleep well and soundly and does not have problems sleeping.

Side effects

Inhalations with Ventolin cause the following undesirable effects:

• from the immune system - allergies (urticaria, Quincke's edema),
• from the digestive system - irritation of the oral mucosa and upper respiratory tract,
• from the nervous system - migraine, tremor of extremities,
• from the heart and blood vessels - hypotension, tachycardia, collapse,
• from the respiratory system - paradoxical bronchospasm with worsening wheezing (develops immediately after using the drug),
• from the muscular system - muscle cramps.

The use of the drug during pregnancy may be justified if the potential benefit to the expectant mother outweighs the possible risk to the fetus. Experts note an increased risk of developing congenital anomalies in children (for example, cleft palate and limb defects) born to women who took salbutamol-based drugs during pregnancy.

Ventolin's medicinal substances easily penetrate into mother's milk, so the use of the drug during lactation is possible with the permission of a doctor. There is no evidence that salbutamol could harm a nursing baby.