Is it possible to replace ceftriaxone with suprax?

Suprax and Ceftriaxone: which is better?

Suprax and Ceftriaxone are drugs of the same cephalosporin group. They are used for otitis media and bronchitis. Despite the similar mechanism of action, these drugs have many differences in dosage, contraindications, and release form. All this must be taken into account when taking it in order to avoid the occurrence of negative reactions from the body.

Suprax and Ceftriaxone are used for otitis media and bronchitis.

Characteristics of Suprax

Suprax is the first third-generation cephalosporin antibiotic. Made on the basis of cefixime. When the drug gets inside, it inhibits the substances that make up the cell wall of bacteria, which leads to their death. The product is also resistant to beta-lactamases - these are enzymes in bacteria that make them resistant to the antibiotic.

This remedy inhibits the action of streptococci, E. coli, Proteus, Salmonella, Shigella, and gonococci. At the same time, staphylococci and listeria are resistant to the action of the drug.

The product is available in the form of tablets, capsules and granules for the preparation of a suspension, a ready-made suspension for children. Prescribed in the following cases:

The dosage depends on the patient’s age and the severity of the pathology: no more than 400 mg of the drug per day for adults, for children – 3-9 mg per kilogram of weight. Treatment with the drug cannot last more than 10 days.

Contraindications for use:

• allergy to cephalosporin drugs;
• children under 6 months, adults over 60 years old;
• pregnancy (can be prescribed if the benefit to the mother outweighs the harm to the fetus, only under the supervision of a doctor);
• kidney diseases.

Adverse reactions of Suprax include abdominal pain and general malaise.

Suprax inhibits the action of streptococci, E. coli, Proteus, Salmonella, Shigella, and gonococci.

Characteristics of Cefixime

The antibiotic has the following characteristics:

1. Dosage form and composition. The drug is available in the form of oval-shaped and white tablets. Each contains 200 or 400 mg of cefixime, cellulose powder, calcium stearate, sodium starch glycolate. Tablets are packaged in blisters of 10 pcs. The antibiotic can also be supplied in powder form, from which a suspension is prepared for oral administration. 5 ml of the finished drug contains 100 mg of cefixime.
2. Mechanism of action. Cefixime inhibits the production of protein compounds used by bacteria to build cell walls. The antibiotic is not destroyed by enzymes secreted by resistant pathogenic microorganisms. Gram-negative pathogens are sensitive to the drug (Pasterella, Citrobacter, Klebsiella, Proteus, Shigella, Serration, Haemophilus influenzae). The active substance has high activity against streptococci and gonococci.
3. Absorption, distribution and excretion. When taken orally, half of the administered dose is absorbed. Therapeutic concentrations of cefixime in the blood are detected within an hour. 60% of the active substance interacts with plasma proteins. Cefixime is excreted unchanged from the body in urine and feces.
4. Scope of use. The list of indications for the use of Cefixime includes the following pathological conditions:
   infectious lesions of the upper respiratory tract and ENT organs (inflammation of the middle ear and maxillary sinuses, tonsillitis, pharyngitis);
5. uncomplicated gonorrhea;
6. infections of the genitourinary system (cystitis, urethritis, prostatitis, pyelonephritis, inflammation of the uterus and appendages).
7. Contraindications. Tablets and suspension are not prescribed for individual intolerance to cephalosporin antibiotics.
8. Mode of application. Take orally during meals. The daily dose is calculated taking into account the type of infection and the age of the patient.
9. Side effects. When taking the drug, the following undesirable consequences may occur:
   digestive disorders (decreased appetite, constant thirst, loose stools, stomach pain, changes in the activity of liver enzymes, increased levels of bilirubin in the blood, ulceration of the mucous membranes of the large intestine, stomatitis, esophageal candidiasis);
10. dysfunction of the hematopoietic system (decrease in the number of platelets, leukocytes and granulocytes, anemia);
11. neurological disorders (headache, dizziness, insomnia);
12. interstitial nephritis;
13. allergic manifestations (itchy skin rashes, hyperemia, increased body temperature, swelling of the face and larynx, urticaria).

Cefixime is used for infectious lesions of the upper respiratory tract and ENT organs (inflammation of the middle ear and maxillary sinuses, tonsillitis, pharyngitis).

Characteristics of Ceftriaxone

This is an antibiotic that belongs to the group of 3rd generation cephalosporins; the active ingredient is ceftriaxone. The drug is available in powder form for intravenous or intramuscular administration. You can take an antibiotic to combat a wide range of bacteria - aerobic, anaerobic. The bioavailability of the drug is 100%, after administration it is well distributed throughout the tissues and enters the cerebrospinal fluid.

After administration, it can penetrate through the placenta into the fetus’s body, and through milk into the child’s body.

The maximum concentration of the substance when administered intramuscularly is observed within 3 hours, when administered intravenously - almost immediately. More than 40% of the antibiotic is excreted in the urine, the rest in feces.

Indications for use:

• infectious diseases of the respiratory tract, ENT organs;
• infected burns;
• sepsis;
• gonorrhea;
• typhoid fever.

Contraindications for Ceftriaxone include:

• sensitivity to components;
• children up to 1 month;
• pregnancy, lactation period;
• liver or kidney failure.

The dosage of the medicine is prescribed individually, taking into account the disease and the severity of the pathology. Adults are prescribed about 2 g of the drug per day; the dosage for children under 12 years of age depends on the child’s body weight.

Ceftriaxone is indicated for use in infectious diseases of the respiratory tract, ENT organs, and infected burns.

What is the difference between Cefixime and Ceftriaxone?

The difference between the drugs is as follows:

1. Main components. Cefixime contains cefixime trihydrate, Ceftriaxone is represented by ceftriaxone.
2. Release forms. Cefixime is available in the form of powder and tablets, and Ceftriaxone has an injection form.
3. Solutions that are used to dilute powder. An injection into a muscle causes pain, so anesthetics are added to the solutions. Cefixime is compatible with lidocaine, and Ceftriaxone is compatible with novocaine.
4. The likelihood of adverse reactions. Cefixime causes more negative reactions in the body.

Comparison of Suprax and Ceftriaxone

These two drugs belong to one third group of antibacterial drugs. Despite the different main active ingredients, they have similar indications for use: pneumonia, infectious and bacterial diseases of the ENT organs, and the genitourinary system.

Similarities between drugs:

• belonging to third generation antibacterial drugs;
• Contraindications – cannot be taken while breastfeeding, if you have allergies, or problems with the kidneys or liver.

The following side effects are also typical for these antibiotics:

• convulsions;
• vomit;
• allergic reaction in the form of itching;
• temperature increase;
• problems in the gastrointestinal tract;
• dizziness and weakness;
• headache;
• drowsiness.

But most often, such symptoms are observed when the dosage is incorrectly selected or the recommendations of a specialist are violated. Having noticed such negative reactions, it is important to visit a doctor to adjust the dosage or choose a different medicine.

What to choose - Zinnat or Ceftriaxone

It is better to choose Zinnat than Ceftriaxone for the following diseases:

• boil, carbuncle, abscess (ulcer) on the skin, in the nasal passage, pustular rash with proven sensitivity of the pathogen (after bacterial culture);
• sore throat, pharyngitis, chronic tonsillitis;
• mild pneumonia with no risk of complications;
• acute bronchitis or exacerbation of chronic (except for viral and fungal origin), tracheitis, tracheobronchitis;
• inflammation of the periungual fold;
• sinusitis, sinusitis, rhinosinusitis;
• acute non-purulent otitis media;
• urinary tract infection with low risk of complications;
• medical abortion performed to prevent infection;
• chronic pyelonephritis with good urine outflow;
• prostatitis;
• cystitis;
• inflammation of the salivary glands.

Ceftriaxone is more effective than Zinnat for infections:

• bones, joints;
• meninges;
• Lyme disease (tick-borne borreliosis);
• in the blood (sepsis);
• lungs – severe pneumonia, especially nosocomial, complicated course;
• abdominal organs - gall bladder, pancreas, peritoneum;
• wound after injury and surgery;
• in patients with weakened immunity;
• kidneys and urinary tract – moderate to severe;
• in children under 3 months.

And here is more information about which is better - Cefotaxime or Ceftriaxone.

Suprax is weaker than Ceftriaxone; it is taken in capsules and suspensions for infections of the respiratory, urinary tract, and ENT organs with a mild and uncomplicated course. Ceftriaxone is a stronger drug with a wide spectrum of antibacterial effect; it is prescribed for moderate and severe bacterial infection, and is administered only by injection. The choice of the best drug is up to the doctor.

Suprax or Ceftriaxone: which is better?

Both of these drugs have an almost identical effect, but Ceftriaxone acts faster because the drug is administered intravenously or intramuscularly. However, for some pathologies, depending on the type of bacteria, Suprax may be more effective. Depending on the patient’s medical history, complaints, and test results, only a doctor can prescribe treatment.

It is also recommended to supplement therapy with probiotics to avoid disruption of the gastrointestinal microflora.

Reviews from doctors and patients

Olga, 38 years old, therapist

For treating children, I choose Suprax, and Ceftriaxone is suitable for children who tolerate injections well. Both medications help fight infection, do not cause side effects, and are inexpensive.

Evgeniy, 41 years old, pediatrician

I regularly prescribe Suprax to young patients. It is cheap, has a high level of bioavailability, and does not lead to side effects if the prescribed treatment regimen is followed. Additionally, it is recommended to take probiotics or lactobacilli to maintain intestinal microflora.

Anna, 23 years old, Moscow

I was sick with meningitis, and in the hospital they injected me with the drug Ceftriaxone along with Lidocaine so that it wouldn’t hurt. But it quickly became better: the fever went away and my overall health improved. A couple of weeks later, my son fell ill, but the doctor prescribed Suprax for the child. It caused diarrhea, so I had to take probiotics.

Evgeniy, 31 years old, Moscow

A week ago there was a strong wind: the nose was stuffy, a cough appeared, and the temperature rose. It turned out to be a sore throat. Ceftriaxone was prescribed. After 2 days there was relief.

Suprax

This is a 3rd generation antibiotic belonging to the group of cephalosporins . The active substance is cefixime . Available in the form of capsules and powder for suspension.

Has bactericidal and antibacterial effects. Upon penetration, it inhibits the synthesis of the bacterial cell membrane.

Bioavailability is 40-50% regardless of food intake. However, when taking the drug with food, the maximum concentration in the blood is observed slightly faster. When taking the drug, both in capsule and suspension form, the maximum concentration is observed after 4 hours.

About 50% of the substance is excreted in the urine, and 10% in the bile. The half-life is 24 hours. If you have kidney problems, this time increases.

Indications are the following diseases:

• Sinusitis, pharyngitis, sinusitis, tonsillitis.
• Otitis.
• Urinary tract infections.
• Bronchitis.
• Uncomplicated gonorrhea.

An absolute contraindication is for use by people with high sensitivity to antibiotics of the cephalosporin and penicillin groups.

Relative contraindications are:

1. Elderly age.
2. Kidney failure.
3. History of colitis.
4. Children under 6 months.

Use is not recommended for pregnant women. It is allowed only if the benefit of taking the drug is higher than the potential harm to the fetus. If a nursing woman needs to take the drug, breastfeeding should be stopped at this time.

For adults and children over 12 years of age, whose weight is more than 50 kg, the daily dose is 400 mg . Can be taken once or 2 times a day, 200 mg . Duration of treatment is 7-10 days .

Suprax or Klacid

The active ingredient of Klacid is clarithromycin, that is, the drug belongs to macrolide antibiotics. It is prescribed if the patient has confirmed atypical sensitivity to cephalosporin and penicillin antibiotics.

Klacid has a wider spectrum of action, so it is prescribed for severe bacterial infections that occur with complications.

It is contraindicated in renal failure, porphyrin disease, liver pathologies, and allergies to macrolides. In view of this, Suprax is considered a safer drug.

• lower cost of the drug;
• wide spectrum of action;

The disadvantages of the drug include a wider list of side effects and contraindications. When taking Klacid, anaphylactic reactions are recorded much more often, so this medicine is prescribed to children with great caution.

Ceftriaxone

An antibiotic belonging to the group of 3rd generation cephalosporins . The active substance is ceftriaxone. Available in powder form for the preparation of an injection solution for intramuscular and intravenous administration. The substance is a white or yellowish microcrystalline powder.

Destroys aerobic, anaerobic, gram-positive and gram-negative bacteria. Bioavailability 100%. It is well distributed in all tissues and fluids of the body, including the cerebrospinal fluid. High concentrations are observed in bile. The substance can penetrate the placenta and also into breast milk. With intramuscular administration, the maximum concentration is observed after 2-3 hours, with intravenous administration - at the end of the infusion. About 40-60% is excreted in urine, and the rest in bile and feces.

• Infections of the abdominal cavity, respiratory tract and ENT organs.
• Infected burns and wounds.
• Infections of the maxillofacial area.
• Sepsis.
• Bacterial meningitis.
• Syphilis.
• Tick-borne borreliosis.
• Uncomplicated gonorrhea.
• Salmonellosis.
• Typhoid fever.

1. Hypersensitivity to components.
2. Children up to 2 weeks.
3. Prematurity.
4. Liver and kidney failure.
5. Pregnancy and breastfeeding.

The dosage is prescribed individually. Administer 1-2 g over 24 hours or 0.5-1 g over 12 hours intravenously or intramuscularly. The maximum daily dose for adults is 4 g , and for children 2 g .

Analogues of the drug

Despite all its advantages, Ceftriaxone may not be suitable for therapy in some cases. This is not only because the medication is very strong and can cause some unwanted side effects, but also because it is available exclusively in powder form for the preparation of an injection solution.

This seriously impedes the use of the medicine, for example, in pediatric practice. Therefore, if a situation arises when it is necessary to find similar medications in which the active ingredient has the same effect as Ceftriaxone, but is devoid of its adverse reactions. Drugs that can replace Ceftriaxone - analogs, are not completely identical to it, but their properties allow them to provide the necessary therapy to patients.

Amikacin

It is difficult to say whether Amikacin is a complete analogue, but the fact that it is a stronger antibiotic can be said with complete certainty. Being a medicine from a completely different group - aminoglycosides - it is used only in the case of very severe infectious diseases, which all standard medicines clearly cannot cope with. The group of aminoglycosides has a fairly impressive list of side effects, and therefore a doctor will never prescribe this drug for a mild illness, and certainly should not be used for a common cold.

Table of current prices for the drug Amikacin

in online pharmacies. Data was last updated on 09/10/2020 00:05.

Amoxiclav

Amoxiclav is not an ordinary drug. The main active ingredient in it is the long-known amoxicillin. However, unlike simple amoxicillin, to which absolutely all bacteria are already accustomed, Amoxiclav combines this substance with another - clavulanic acid. This acid itself does not kill microbes, but it should not be perceived as a useless component. It fights bacterial resistance to penicillin antibiotics by binding an enzyme that breaks down the main part of the molecule of such antibiotics - the beta-lactam ring.

Therefore, Amoxiclav, on the one hand, can be used as a remedy against resistant microorganisms (after all, cephalosporin antibiotics also have a beta-lactam ring and can also be inactivated by such microbes). But, on the other hand, the active substance there is much weaker. Therefore, such a replacement should be made only with the permission of the doctor and only after receiving information about the advisability of such a replacement.

However, the undoubted advantage of Amoxiclav, in addition to its security, is that it is produced in the form of capsules, which greatly facilitates its use.

Next, we will look at analogues of Ceftriaxone in injections and suspension.

Table of current prices for the drug Amoxiclav

in online pharmacies. Data was last updated on 09/10/2020 00:05.

Rocephin

This medication is a structural analogue or, in other words, a synonym for Ceftriaxone, which is produced by domestic manufacturers. Rocephin is produced by a Swiss company and what distinguishes it from the domestic version, in addition to the country of production, is also the 2% lidocaine for dilution attached to the ampoule with the powder itself.

In addition, Rocephin is a very highly purified drug, which further reduces the likelihood of unwanted side effects during use. However, its cost is quite high compared to other products - 450-600 rubles for 1 bottle of antibiotic.

Table of current prices for the drug Rocephin

in online pharmacies. Data was last updated on 09/10/2020 00:05.

Suprax

Suprax is the trade name of a drug containing cefixime. This is a 3rd generation cephalosporin antibiotic. Since Ceftriaxone and Suprax both belong not only to the same series of antibiotics, but even to the same generation, they can be considered almost complete substitutes for each other. However, Suprax has a slightly narrower spectrum of action, so before making a clear decision about which is better - Suprax or Ceftriaxone - you need to clarify how effective Suprax will be for a specific bacterial infection.

The clear advantage of this drug is that it is available in many different forms, from capsules to granules, from which a suspension can be prepared. This makes it indispensable for children's practice. This also allows the patient to take the medicine with convenience, which is impossible for Ceftriaxone, which must only be injected.

Table of current prices for the drug Suprax

in online pharmacies. Data was last updated on 09/10/2020 00:05.

Cefazolin

Just like Ceftriaxone, it is available only in ampoules for injections. It belongs to the 1st generation cephalosporins, and therefore is somewhat different in action from this medication, first of all, in its narrower spectrum of action. But, at the same time, it has a much smaller list of side effects. Therefore, if serious adverse reactions develop, the doctor may replace Ceftriaxone with it.

Table of current prices for the drug Cefazolin

in online pharmacies. Data was last updated on 09/10/2020 00:05.

Cefepime

A newer drug from the group of 4th generation cephalosporins. It fights a large number of microorganisms, but has a higher price. Also requires only injection administration.

Table of current prices for the drug Cefepime

in online pharmacies. Data was last updated on 09/10/2020 00:05.

What to choose?

These drugs are similar in many ways, but they also have many differences. The main difference is that they have different active ingredients. Due to this, the mechanism of action is slightly different.

The release forms also differ. Ceftriaxone can only be used as an injection. In turn, Suprax is available in the form of capsules and suspensions, which is convenient for children.

Ceftriaxone has a wider spectrum of action, which allows it to cure many more diseases.

The main difference is the price category. Ceftriaxone can be purchased at a price of 30-40 rubles per ampoule . The price for Suprax starts from 600 rubles , depending on the form of release.

Both drugs have almost identical side effects, including:

• Increased temperature, fever.
• Allergic reaction (itching, rash).
• disorders of the gastrointestinal tract.
• Weakness, dizziness.
• Diarrhea.
• Migraine.
• Drowsiness.

This usually occurs when the drug is taken incorrectly or in an overdose.

Also similar is that the drugs belong to the same pharmacological group. Also, both drugs are prohibited during pregnancy, breastfeeding, and liver and kidney problems.

The advantages of Suprax are:

1. Availability of forms convenient for use by children.
2. Effectively destroys streptococci.
3. It is effective in the treatment of COPD.
4. It is enough to apply once a day.
5. A dissolvable tablet form is available for people who have trouble swallowing.

• Wide spectrum of action.
• Affordable price.
• Possibility of prescribing to children starting from 2 weeks after birth.
• Penetrates into all tissues and liquids.
• Well tolerated by patients.

Both antibiotics have almost the same medicinal qualities . Many doctors believe that Ceftriaxone works faster and more effectively. However, there are diseases for which Suprax helps better.

Thus, it is impossible to say unambiguously which drug is more effective. Antibacterial drugs are always prescribed by a doctor, based on the clinical picture of the disease and the pathogen. It is not recommended to self-medicate, as taking antibiotics without medical supervision can lead to an overdose and the development of side effects.

Dosage regimen

Intravenously, intramuscularly. Adults and children over 12 years old - 1-2 g once a day or 0.5-1 g every 12 hours, the daily dose should not exceed 4 g. For newborns (up to 2 weeks) - 20-50 mg/kg/day. For infants and children under 12 years of age, the daily dose is 20-80 mg/kg. In children weighing 50 kg and above, adult doses are used. A dose of more than 50 mg/kg body weight should be administered as an intravenous infusion over 30 minutes. The duration of the course depends on the nature and severity of the disease. For gonorrhea - intramuscularly once, 250 mg. To prevent postoperative complications - once, 1-2 g (depending on the degree of danger of infection) 30-90 minutes before the start of surgery. During operations on the colon and rectum, additional administration of a drug from the group of 5-nitroimidazoles is recommended. For bacterial meningitis in infants and young children - 100 mg/kg (but not more than 4 g) 1 time per day. The duration of treatment depends on the pathogen and can range from 4 days for Neisseria meningitidis to 10-14 days for susceptible strains of Enterobacteriaceae. Children with skin and soft tissue infections - a daily dose of 50-75 mg/kg once a day or 25-37.5 mg/kg every 12 hours, not more than 2 g/day. For severe infections of other localization - 25-37.5 mg/kg every 12 hours, no more than 2 g/day. For otitis media - intramuscularly, once, 50 mg/kg, no more than 1 g. For patients with chronic renal failure, dose adjustment is required only when CC is below 10 ml/min. In this case, the daily dose should not exceed 2 g.

Rules for the preparation and administration of solutions

Only freshly prepared solutions should be used. For intramuscular administration, 0.25 or 0.5 g of the drug is dissolved in 2 ml, and 1 g in 3.5 ml of a 1% lidocaine solution. It is recommended to inject no more than 1 g into one buttock. For intravenous injection, 0.25 or 0.5 g is dissolved in 5 ml, and 1 g in 10 ml of water for injection. Administer intravenously slowly (2-4 minutes). For intravenous infusion, dissolve 2 g in 40 ml of a Ca2+-free solution (0.9% NaCl solution, 5-10% dextrose solution, 5% levulose solution). Doses of 50 mg/kg or more should be administered intravenously over 30 minutes.

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