Suprax for sinusitis: for adults and children

Composition and dosage form

The active ingredient of the drug is cefixime, 0.4 g each. Auxiliary components include flavorings, cellulose, silicon dioxide, magnesium stearate.

For children it is sold in the form of granules, from which a suspension is prepared. There are thirty or sixty grams of granules in a bottle. 5 ml of the finished suspension contains 100 mg of antibiotic.

Suprax is sold in 1, 5 or 7 tablets or capsules in a blister , two blisters per package with instructions from the manufacturer. Dispensed with a doctor's prescription.

How does Suprax work and can it help with sinusitis?

The antibiotic works quickly, helps with sinusitis and its forms, improvements occur within 2-3 days from the start of treatment.

Composition and active substance

The active substance in Suprax is cefixime. This cephalosparin is one of the strong treatment options. This substance is resistant to β-lactamases, which protect pathogenic flora.

The dangers of mycetoma of the maxillary sinus can be found out here.

Suprax is available in different release forms, because... can be used in both adults and children. There are several options:

Capsules of 200 and 400 mg: 6 pieces in a blister.
Granules for suspension: 100 mg per 5 ml of white or cream-colored product; after the mass is mixed with water, a suspension with a strawberry aroma is obtained.
Dispersible tablets with a dosage of 400 mg: these options are pale orange in color.

The drug works for sinusitis in the following way: after taking the drug, the active substance in an amount of 40-50% is delivered directly to the lesion, in this case to the maxillary sinuses. There, cefixime begins to actively bind to plasma proteins (we are talking mainly about albumin) and penetrates into the foci of inflammatory processes. The required concentration of the substance is achieved in 4 hours.

The instructions for using Ximelin can be found by clicking on the link.

What forms of disease does it help with?

Can the drug help with different forms of the disease? Most often, an antibiotic is suggested to be taken in the acute phase of the development of pathology. If the treatment is carried out correctly, the result will be noticeable. If you interrupt the course or change the dosage yourself, the acute form may become chronic. Here, too, it is possible to prescribe Suprax, but more often for the treatment of concomitant pathologies that are associated with inflammatory processes in the maxillary sinuses.

Medicinal properties

Suprax contains an antibiotic of semi-synthetic origin from the group of new generation cephalosporins. Shows active action against bacterial agents. The mechanism of this action is associated with a violation of the integrity of the bacterial cell membranes. Resistant to beta-lactamase of a wide range of bacteria.

Suprax is active against streptococci, Klebsiella, salmonella, enterococci, clostridia, enterobacter and a wide range of other infectious pathogens.

Peak blood concentrations are achieved within 4 hours after administration . The half-life is about three hours, excreted in the urine, half unchanged. In case of renal failure, the half-life doubles; in patients with liver disease, the elimination period increases to 6.5 hours.

Composition, properties and release form of Suprax

Suprax is a broad-spectrum antibacterial drug

The active use of the drug Suprax for sinusitis is due to its positive effect on the patient’s condition with this disease. Suprax is a third generation antibiotic cefixime from the group of cephalosporins. It is effective against most gram-positive and gram-negative microorganisms belonging to pathogenic microflora. An important property of this drug is its ability to fight staphylococci, which are the cause of the vast majority of cases of sinusitis.

Staphylococci can live on the skin and mucous membranes of a person, without showing their presence in any way until a malfunction occurs in the body, causing a decrease in immunity. Most often this is banal hypothermia. As a result, a person develops a runny nose, and staphylococci receive an excellent nutrient medium for their rapid reproduction.

A person develops purulent sinusitis, in most cases the treatment of which will require the use of a specific antibiotic.

Suprax copes well with this role, inhibiting the growth of staphylococcal colonies and leading to their death.

The drug is available in the following forms:

Suspension for children with strawberry flavor 60 ml.
Granules for preparing a suspension.
Capsules (6 pieces per package of 200 mg and 6 pieces per package of 400 mg).

The shelf life of the product is 36 months from the date of release. Store the drug in a place protected from sunlight and high temperatures, as far as possible from the access of children. It is especially important to hide the special baby suspension from them. It has a sweet berry taste, so it can be mistaken for food by kids.

An overdose can be dangerous, especially for an imperfect child's body. It manifests itself with increased signs of side effects, requiring urgent gastric lavage and seeking medical help.

Etiology of sinusitis

To determine whether it is effective to treat sinusitis with Suprax, you should compare the spectrum of action of the antibiotic with the possible causative agents of sinusitis.

The main role in the development of sinusitis is played by pathogenic microorganisms, including bacteria:

streptococci;
staphylococci;
Haemophilus influenzae.

Viral diseases can also provoke the development of sinusitis as a complication. This happens when infected with influenza virus, parainfluenza, rhinoviruses, coronaviruses.

Pathogenic fungi, including aspergillus, mucoraceae, and candida, can also cause the development of sinusitis. Factors contributing to the development of sinusitis in humans are the following conditions :

decreased immune response of the body;
the presence of congenital anomalies of the sinuses or acquired curvature of the nasal septum;
neoplasms in the nasal cavities: polyps, cysts, tumors;
respiratory viral infections, allergies;
dental infections, sudden changes in pressure.

Penetration of filling material into the cavity is often observed when the quality of treatment of the teeth of the upper jaw is poor. In this case, the filling material may be sterile, but will still provoke the development of infection. When sinusitis is caused by tumors or foreign bodies, they must be removed.

Cephalosporins are the antibiotics of choice for sinusitis, along with penicillins, macrolides and azalides. In case of intolerance to a drug from one of the groups, the doctor selects an analogue from the other, always taking into account the spectrum of activity.

Composition and pharmacological action

The active substance of the drug is cefixime, a 3rd generation antibiotic. It resists the protective factor of pathogenic microflora, causing the death of bacteria. This element is included in the medication in the form of salt, which is able to overcome the aggressive environment of the stomach in order to decompose in the intestines and then be absorbed into the blood.

The second element of the medication is excipients. Their set differs for different forms of the product.

For diabetics, it is important to consider the inclusion of sucrose.

Clinical picture of the disease

The symptomatic complex of sinusitis consists of general and local symptoms. Local symptoms of sinusitis include the following :

constant nasal congestion;
night snoring and daytime heavy breathing;
flow of mucus from the nasal passages;
lacrimation, lack of smell;
discomfort, pressure in the maxillary sinuses;
pain in the bridge of the nose and in the area of the maxillary sinuses;
headaches in the temporal lobes, worse when moving the head.

At the first symptoms, it is important to consult a doctor and begin diagnosis. Chronic sinusitis is dangerous due to increasingly severe exacerbations. In severe cases, complications are accompanied by purulent bone lesions with penetration of the pathogen into the meninges. This complication is accompanied by additional symptoms of meningitis and dangerously severe conditions, even death in the absence of any treatment.

conclusions

Antibiotics are required to treat sinusitis. One of the modern and strong Suprax.
Suprax is resistant to beta-lactamases, which allows it to more effectively fight bacteria and ensure faster cleansing of sinuses from purulent contents.
There are several forms of release: dosages of 200 mg and 400 mg, they can be used either once a day or twice in half a dose.
There are contraindications for use, and potential risks for the elderly and pregnant women must also be taken into account.

We also recommend that you familiarize yourself with ways to combat headaches due to sinusitis in this material.

The antibiotic Suprax for sinusitis is effective if it is used correctly and used strictly according to medical prescription. The drug will help cope with the active purulent process and will quickly bring relief in the complex treatment of sinusitis.

Efficacy and indications of Suprax

In cases where sinusitis is caused by bacterial agents, antibiotics are the drugs of choice. Suprax for sinusitis, due to its wide spectrum of activity, eliminates the root cause - the bacterial causative agent of the pathology.

It is important to note that in situations where the cause is a fungus or viral infection, Suprax will not be effective. In such cases, antimycotic and antiviral drugs are prescribed.

For this reason, a bacteriological culture from the nasal sinuses is first carried out to determine the microflora. A healthy person has no microflora in the maxillary sinuses - they are sterile. After determining the causative agent, the otolaryngologist or infectious disease specialist will prescribe Suprax or other drugs depending on the specific cause.

Suprax is prescribed for the following pathologies:

upper respiratory tract infections;
infections of the nasopharynx, oropharynx;
acute and chronic infectious pathologies of the urinary tract.

Only the attending physician can recommend Suprax for the treatment of sinusitis or other infectious pathologies. Choosing an antibiotic on your own is dangerous due to severe side effects and a decrease in the body’s overall immune response.

Suprax for sinusitis in adults and children: instructions for use, reviews, does it help?

In the complex therapy of sinusitis, the choice of antibiotic is of great importance.
For greater effectiveness of treatment, it is desirable to identify the pathogen and determine its sensitivity to various groups of antibiotics. The detection of a pathogen reaction to cephalosporins gives reason to choose Suprax. Today, this is one of the effective modern drugs successfully used in the treatment of sinusitis.

Clinical practice shows that Suprax for sinusitis allows you to cope with various forms of the disease in both adults and children.

Composition and pharmacological action

Suprax is a broad-spectrum antibacterial drug with a bactericidal effect (causing death) against gram-positive and gram-negative microflora.

The active component of the drug is cefixime, which belongs to the third generation of the cephalosporin group. Its peculiarity is its resistance to β-lactamases, a protective factor of pathogenic microflora.

The principle of action of the drug is based on the ability of cefixime to inhibit the synthesis of membranes of pathogenic microflora, which leads to its weakening and destruction without damage to human cell membranes.

Release forms

Suprax is a medicine for internal use, available in the following forms:

Capsules – 400 and 200 mg, 6 pieces in a blister made of polymer film and foil. The capsules, which have a purple cap and a white base with code H808, are filled with yellowish-white powder and small granules. Excipients: colloidal silicon dioxide, magnesium stearate, calcium carmellose.
Granules for oral suspension, white to cream, 100 mg/5 ml, available in a dark glass bottle with a capacity of 30.3-35.0 ml. After mixing with water, a strawberry-flavored suspension is formed. Excipients: sodium benzoate, sucrose, xanthan gum, strawberry flavor. There are 2 varieties of this form of the drug: one includes a dosing spoon - 5 or 10 ml, the other includes a 5 ml dosing syringe.
Dispersible tablets, 400 mg: 1, 5, 7 or 10 pcs. The tablets are pale orange in color, scored on both sides, and have an oblong shape. Excipients: microcrystalline cellulose, low-substituted hyprolose, silicon dioxide, povidone, magnesium stearate, strawberry flavor.

Distribution of the drug in the body

The amount of cefixime delivered by blood to its destination (in this case, the maxillary sinuses) is 40–50%.

The active substance actively binds to plasma proteins (mainly albumin) and penetrates into areas of inflammation, reaching the required concentration after 4 hours. Approximately 50% of cefixime is excreted in the urine within 24 hours, 10% is excreted in bile.

The half-life of the drug may be longer in patients with impaired renal function.

Taking the drug in adult patients

For adults and children over 12 years of age who weigh more than 50 kg, Suprax is recommended to be taken in capsule form. One capsule contains 400 mg of active ingredient, taken 1 time per day.

Another dosage option is 2 capsules of 200 mg 2 times a day. An alternative to capsules are Suprax Solutab tablets, 400 mg. The tablet, like the capsule, is washed down with water or dissolved to obtain a suspension.

To maintain the required concentration of cefixime in the body, the medicine should be taken at the same time.

No relationship was found between the bioavailability of the active ingredient and food intake. At the same time, studies have shown that the maximum concentration of the drug in the body is achieved if it is taken with food.

The duration of treatment is on average 5–7 days under the supervision of a doctor.

Taking Suprax by children

For children from six months to 12 years old, Suprax is prescribed in the form of a suspension. Each 5 ml of the finished suspension contains 100 mg of cefixime. The dose is determined at the rate of 8 mg per 1 kg of body weight and is given to the child once a day (or 2 times at the rate of 4 mg of the drug per 1 kg of body weight). The course of treatment averages 5–7 days, the child must be observed by a specialist.

It is important to prepare the suspension correctly: add 40 ml of clean boiled water to the bottle with granules. The suspension must stand for at least 5 minutes to ensure uniform dissolution of the granules. When used directly, the contents of the bottle are shaken and poured into a measuring spoon or taken out with a dosage syringe.

Prescription of Suparks during pregnancy and lactation

No studies have been conducted on the effect of Suprax on fetal development, but the fact that cefixime penetrates the placenta has been established. In this regard, the decision to use the drug in the treatment of a pregnant woman is made exclusively by the doctor. It is important to weigh the pros and cons so that the predicted benefit for the woman significantly outweighs the risk of complications for the fetus.

If therapy is indicated for a nursing mother, then breastfeeding is stopped for the period of treatment.

Contraindications and side effects

There are a number of physiological and pathological conditions in which taking Suprax is unsafe.

Contraindications:

Hypersensitivity to cephalosporins and penicillins.
Age up to six months.
The medicine is prescribed with caution to elderly patients, pregnant women, as well as patients with renal failure and a history of pseudomembranous colitis. If necessary, the dose is reduced by 25–50%. Treatment is carried out in a hospital setting.

Possible negative manifestations

In general, Suprax is well tolerated by most patients; side effects of the drug are rarely recorded - 1 in 10,000 cases. However, it is possible:

From the digestive tract: dry mouth, inflammation of the oral mucosa and tongue, lack of appetite, nausea, vomiting, stool upset, flatulence, jaundice, colitis, candidiasis.
Allergic reactions: skin itching, redness of certain parts of the body, fever.
In the blood there may be a sharp decrease in leukocytes, platelets, neutrophils, as well as anemia.
From the nervous system: headache, dizziness, loss of orientation in space.
Genitourinary disorders: nephritis, urethritis; Women may develop nonspecific vaginitis and candidiasis.

Separately, we note that taking antibiotics for sinusitis, as with other diseases, is often accompanied by a disruption of the normal intestinal microflora, so complex therapy should include probiotics.

Interaction with other medicinal substances

Laboratory studies show:

antacids, including aluminum and magnesium hydroxide, slow down the absorption of the drug;
diuretics, allopurinol and other blockers of tubular secretion slow down the excretion of cefixime by the kidneys, as a result of which its toxic effect on the body increases;
while taking Suprax, which reduces the prothrombin index, the effect of indirect anticoagulants is enhanced;
drinking alcohol during therapy is undesirable, since the liver does not have time to produce a sufficient amount of enzymes to simultaneously neutralize ethyl alcohol and the drug, which contributes to increased intoxication.

Suprax's analogs

Due to the lack of a clear therapeutic effect, the doctor can select an analogue of the drug. These include:

Ixim Lupin.
Cefix.
Ceforal Solutab.
Pantsef.
Cemidexor.

All of these medications contain cefixime trihydrate. The differences lie in the forms of release, doses, and price.

In addition, we can mention drugs such as Cedex and Sumamed. The active substance of the first is ceftibuten, which is also a cephalosporin and a bactericide, so its mechanism of action is not fundamentally different from Suprax.

The active ingredient of Sumamed is azithromycin, which is characterized by a bacteriostatic type of effect on pathogens, that is, it does not destroy them, but stops their reproduction. At the same time, the drug has a prolonged effect (5 - 7 days) and can be prescribed in short courses. The choice should be based on determining the sensitivity of the pathogen to a particular drug.

Where can I buy?

Suprax can be purchased in pharmacies in Russia and the CIS countries. The average cost of Suprax (capsules, 400 mg No. 6) is 770 rubles. Granules for suspension (100 mg / 5 ml 30.3-35 g, 60 ml bottle) will cost an average of 650 rubles per package. Manufacturer – Saudi Arabia, Jordan. The average cost of Suprax Solutab tablets (400 mg No. 7) is 850 rubles. Manufacturer – Italy.

Reviews from doctors and patients

Most reviews from ENT specialists, as well as patients who have undergone treatment for sinusitis, indicate a positive effect of the drug. Difficulty breathing, swelling of the nasal mucosa, and pain are noticeably reduced after just one or two doses. This antibiotic is often prescribed to adults and children.

However, some believe that the drug did not help get rid of sinusitis and its manifestations. An unsatisfactory therapeutic effect may be due to the wrong choice of antibiotic (without taking into account the sensitivity of pathogenic microflora to it). Another possible reason is purchasing a fake.

To avoid buying counterfeits, you should pay attention to the quality of packaging, printing ink, and the presence of instructions. In addition, it makes sense to check the batch of the drug.

Pharmacy workers, in compliance with the articles of responsibility for the distribution of counterfeit drugs, are required to provide all necessary certificates.

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Directions for use and dosage

For sinusitis, adults take Suprax in therapeutic dosages: adults and children over twelve years old can take no more than 0.4 g per day in one or two doses.

The tablet is first dissolved in half a glass of water or drunk whole , followed by water. When using the solution, drink it immediately after preparation. The use of Suprax does not depend on food intake. The tablet can be divided into two doses.

The duration of treatment with Suprax depends on how severe the sinusitis is and whether it is advanced. After all the symptoms of bacterial infection disappear, you need to take Suprax for at least another one or two days.

To prevent complications, the following courses of therapy with Suprax are recommended::

associated upper respiratory tract infections – up to ten days;
lower respiratory tract – up to two weeks;
otitis, sinusitis - from ten to fourteen days.

Treatment of pathologies caused by group A streptococcus should be carried out with Suprax for at least ten days to prevent complications on the urinary system and musculoskeletal system.

Patients with diseases of the urinary system should be prescribed treatment for sinusitis with Suprax with caution; the daily dosage in this case is 0.2 g and taken at a time.

Suspension

For sinusitis in children, Suprax in tablets is allowed from twelve years of age, at a younger age - in the form of a suspension. The amount of medication depends on age and is approximately :

from six months to a year – 2.5-4 ml of the prepared suspension per day;
from 2 to 4 years – 5 ml per day;
from 5 to 11 years – from 6 to 10 ml per day in two doses.

The dosage of Suprax for sinusitis is calculated at 8 mg per kilogram of the child’s body weight. The calculated dosage is taken at one time or divided into two doses. To simplify the calculation, when using Suprax in two doses, you can calculate the dosage of 4 mg per kilogram of body weight before each use. If used twice a day, it is important to maintain an equal time interval between doses of Suprax - twelve hours.

Dosage for adults and antibiotic use

To obtain a sustainable effect, antibiotics must be taken according to certain regimens and taking into account the patient’s weight. For adults it is better in capsule form. It is enough to use 1 capsule with 400 mg of active substance once a day. The option with a 400 mg tablet also works.

Another scheme may be proposed, in which 2 capsules of 200 mg are used twice a day. Be sure to drink it with water. To ensure that the required amount of the active substance is formed in the body, take the drug at the same time. Its highest concentration is obtained if antibiotics are used with food.

How many days to take an antibiotic

How many days should I take the drug? On average, the course of treatment is 5-7 days. You cannot interrupt treatment on your own, because the medicine will not have time to destroy all pathogenic microflora. The disease will enter a chronic stage and resistance to the drug will develop. It is also impossible to increase the dosage, in this case the beneficial intestinal microflora will suffer.

You can find out whether sick leave is given for sinusitis here.

Complex treatment

The drug Suprax treats sinusitis due to its antibacterial activity, but symptomatic drugs may also be present in the combination treatment. They enhance the effect of Suprax, alleviate the patient’s condition and promote a speedy recovery.

Combination treatment includes:

antibiotics that eliminate pathogenic microflora;
probiotics, which add beneficial bacteria and enhance local immunity;
vasoconstrictor and anti-inflammatory drops;
softening drops to restore the nasal mucosa;
rinsing the sinuses with antiseptic solutions and antibiotics.

The latter procedure is unacceptable at home and is performed only by an otolaryngologist. Rinsing allows you to free the sinuses during sinusitis from accumulated purulent masses and secretions, prevent the spread of infection and eliminate inflammation.

Description of the drug

Composition and pharmacological action

Suprax is a broad-spectrum antibacterial drug with a bactericidal effect (causing death) against gram-positive and gram-negative microflora.
The active component of the drug is cefixime, which belongs to the third generation of the cephalosporin group. Its peculiarity is its resistance to β-lactamases, a protective factor of pathogenic microflora. The principle of action of the drug is based on the ability of cefixime to inhibit the synthesis of membranes of pathogenic microflora, which leads to its weakening and destruction without damage to human cell membranes.

Release forms

Suprax is a medicine for internal use, available in the following forms:

Capsules – 400 and 200 mg, 6 pieces in a blister made of polymer film and foil. The capsules, which have a purple cap and a white base with code H808, are filled with yellowish-white powder and small granules. Excipients: colloidal silicon dioxide, magnesium stearate, calcium carmellose.
Granules for oral suspension, white to cream, 100 mg/5 ml, available in a dark glass bottle with a capacity of 30.3-35.0 ml. After mixing with water, a strawberry-flavored suspension is formed. Excipients: sodium benzoate, sucrose, xanthan gum, strawberry flavor. There are 2 varieties of this form of the drug: one includes a dosing spoon - 5 or 10 ml, the other includes a 5 ml dosing syringe.
Dispersible tablets, 400 mg: 1, 5, 7 or 10 pcs. The tablets are pale orange in color, scored on both sides, and have an oblong shape. Excipients: microcrystalline cellulose, low-substituted hyprolose, silicon dioxide, povidone, magnesium stearate, strawberry flavor.

Dosage and food intake

The dosage of the drug for children varies depending on the complexity of the disease, the age and weight of the child. So, for six-month-old children, the dose cannot exceed 2.5 ml per day, and for one-year-old children - 4 ml. At a slightly older age (2-4 years), the dose increases to 5 ml. And at 5-11 years old, the dosage becomes maximum for children - 6-10 ml.

For adults and adolescents (from 12 years old), the dose can be 200 or 400 mg. In this case, the use of capsules is appropriate.

For any age, taking the drug in question can be divided into 2 times. It is important to know that the time between doses should not exceed 12 hours for the desired effect.

The instructions for the drug do not indicate an exact recommendation to take Suprax before or after meals, but only that the functioning of the gastrointestinal tract does not affect the effect of the drug. However, studies have found that when the medicine is taken with food, the rate of entry into the blood increases. But it turned out that taking Suprax before meals is not recommended due to the possible unpleasant effects of the potent substance on the liver. For the same reason, the researchers concluded that giving Suprax to a child after eating would be much safer.

It is very important for complete recovery not only the dosage, but also the duration of use. It is imperative to follow the doctor’s instructions and give Suprax to your child, even if improvements become noticeable. The full course usually does not exceed 14 days, but consists of 7-10.

Children need a strong immune system for good health. Suprax has a minimal effect on the beneficial microflora of the child, but has the greatest impact on the protective barriers of pathogens.

There are a lot of reviews on the Internet that confirm the high effectiveness of the drug in question, and for the best effect you need to take Suprax in a timely and correct manner.

Parents should also know that if a child is allergic to any foods or medications, then before using Suprax it is necessary to undergo special tests that can reveal intolerance to the drug.

Sometimes, with inflammation of the maxillary sinuses, it is necessary to resort to antibiotic therapy. In such a situation, the otolaryngologist prescribes the use of an antibacterial agent with a broad spectrum of action - Suprax. Let's look at the instructions for using this drug.