Home Sore throat Treatment of sore throat How effective is ciprofloxacin for sore throat in adults?
When antibiotics or antimicrobial drugs almost always prescribed to eliminate the causative agent of the disease and prevent the development of third-party infectious pathologies.
One such drug is ciprofloxacin..
The drug has been used for decades and reviews about it are contradictory, since, despite its effectiveness, it itself can provoke the development of serious diseases and complications.
Therefore, you can take it only as prescribed by a doctor.
- 1 General information about ciprofloxacin
- 2 Efficacy of ciprofloxacin for angina
- 3 How to use for the treatment of sore throat in adults?
- 4 Side effects
- 5 Reviews
- 6 Useful video
General information about ciprofloxacin
Keep in mind! Cifprofloxacin is a universal drug with a broad spectrum of action.
It not only fights the pathogens of sore throat, but also has a bactericidal effect , preventing further proliferation of microbes on the surface of the tissues of the larynx and palatine tonsils.
The product affects microorganisms at the cellular level, disrupting in their DNA the processes of protein synthesis involved in the formation of cells of such bacteria.
In the treatment of sore throat and other diseases caused by gram-positive and gram-negative bacteria, the drug is most effective .
Although some strains of coccal infections are insensitive to this remedy.
In most cases, ciprofloxacin for angina is prescribed in the form of tablets, but in case of serious complications, the medicine is administered as an infusion solution through a dropper.
You should know! The composition of the drug in tablet form includes:
- the main active substance is ciprofloxacin monohydrate hydrochloride;
- polyethylene oxide-4000;
- corn starch;
- titanium dioxide;
- medical polyvinylpyrrolidone;
- Magnesium stearate.
The substances included in the drug often provoke the development of various side effects .
Therefore, they try to prescribe such tablets only in extreme cases when other antibiotics are not effective.
CIPROFLOXACIN
– ciprofloxacin (ciprofloxacin) – ciprofloxacin (hydrochloride form) (ciprofloxacin)
Composition and release form of the drug
Film-coated tablets
white or almost white, oval, scored, biconvex; On a cross section, the kernel is white to slightly yellowish in color.
1 tab. | |
ciprofloxacin hydrochloride | 873.3 mg, |
which corresponds to the content of ciprofloxacin | 750 mg |
Excipients: corn starch - 10.8 mg, pregelatinized corn starch - 90 mg, microcrystalline cellulose - 129.3 mg, crospovidone - 23.1 mg, magnesium stearate - 11.4 mg, lactose monohydrate - 39.9 mg, talc - 22.2 mg.
Film shell auxiliary substances:
hypromellose – 17.34 mg, polyethylene glycol 6000 – 7.32 mg, titanium dioxide – 2.67 mg, polysorbate 80 – 2.67 mg.
5 pieces. – contour cell packaging (1) – cardboard packs. 5 pcs. – contour cell packaging (2) – cardboard packs. 5 pcs. – contour cell packaging (4) – cardboard packs. 10 pcs. – contour cell packaging (1) – cardboard packs. 10 pcs. – contour cell packaging (2) – cardboard packs. 10 pcs. – cans (1) – cardboard packs.
20 pcs. – cans (1) – cardboard packs.
pharmachologic effect
Broad-spectrum antimicrobial agent of the fluoroquinolone group. Has a bactericidal effect. Suppresses DNA gyrase and inhibits bacterial DNA synthesis.
Highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.
Active against Staphylococcus spp. (including strains that produce and do not produce penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.
Ciprofloxacin is active against bacteria that produce β-lactamases.
Ureaplasma urealyticum, Clostridium difficile, and Nocardia asteroides are resistant to ciprofloxacin. The effect against Treponema pallidum has not been sufficiently studied.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract. Bioavailability after oral administration is 70%. Food intake has little effect on the absorption of ciprofloxacin. Plasma protein binding is 20-40%.
Distributed in tissues and body fluids. Penetrates into the cerebrospinal fluid: concentrations of ciprofloxacin with non-inflamed meninges reach 10%, with inflamed meninges - up to 37%.
High concentrations are achieved in bile. Excreted in urine and bile.
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin, incl. diseases of the respiratory tract, abdominal cavity and pelvic organs, bones, joints, skin; septicemia; severe infections of the ENT organs. Treatment of postoperative infections. Prevention and treatment of infections in patients with reduced immunity.
For local use: acute and subacute conjunctivitis, blepharoconjunctivitis, blepharitis, bacterial corneal ulcers, keratitis, keratoconjunctivitis, chronic dacryocystitis, meibomitis. Infectious eye lesions after injury or foreign bodies. Preoperative prophylaxis in ophthalmic surgery.
Dosage
Individual. Orally – 250-750 mg 2 times/day. The duration of treatment is from 7-10 days to 4 weeks.
For intravenous administration, a single dose is 200-400 mg, the frequency of administration is 2 times a day; Duration of treatment is 1-2 weeks, or more if necessary. It can be administered intravenously as a stream, but drip administration over 30 minutes is more preferable.
When applied topically, instill 1-2 drops into the lower conjunctival sac of the affected eye every 1-4 hours. After the condition improves, the intervals between instillations can be increased.
Maximum daily dose
for adults when taken orally it is 1.5 g.
From the digestive system:
nausea, vomiting, diarrhea, abdominal pain, increased activity of liver transaminases, alkaline phosphatase, LDH, bilirubin, pseudomembranous colitis.
From the side of the central nervous system:
headache, dizziness, feeling tired, sleep disorders, nightmares, hallucinations, fainting, visual disturbances.
From the urinary system:
crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, transient increase in serum creatinine.
From the hematopoietic system:
eosinophilia, leukopenia, neutropenia, changes in platelet count.
From the cardiovascular system:
tachycardia, heart rhythm disturbances, arterial hypotension.
Allergic reactions:
skin itching, urticaria, Quincke's edema, Stevens-Johnson syndrome, arthralgia.
Adverse reactions associated with chemotherapy:
candidiasis.
Local reactions:
pain, phlebitis (with intravenous administration). When using eye drops, in some cases, mild soreness and hyperemia of the conjunctiva are possible.
Other:
vasculitis
Drug interactions
With simultaneous use of ciprofloxacin with didanosine, the absorption of ciprofloxacin is reduced due to the formation of ciprofloxacin complexes with aluminum and magnesium buffers contained in didanosine.
When used simultaneously with warfarin, the risk of bleeding increases.
With the simultaneous use of ciprofloxacin and theophylline, it is possible to increase the concentration of theophylline in the blood plasma, increase T1/2 of theophylline, which leads to an increased risk of developing toxic effects associated with theophylline.
Simultaneous use of antacids, as well as drugs containing aluminum, zinc, iron or magnesium ions, can cause a decrease in the absorption of ciprofloxacin, so the interval between the administration of these drugs should be at least 4 hours.
special instructions
In patients with impaired renal function, dosage regimen adjustment is required. Use with caution in elderly patients, with atherosclerosis of cerebral vessels, cerebrovascular accidents, epilepsy, and convulsive syndrome of unknown etiology.
During treatment, patients should receive sufficient fluids.
In case of persistent diarrhea, ciprofloxacin should be discontinued.
With simultaneous intravenous administration of ciprofloxacin and barbiturates, monitoring of heart rate, blood pressure, and ECG is necessary. During treatment, it is necessary to control the concentration of urea, creatinine, and liver transaminases in the blood.
During treatment, a decrease in reactivity is possible (especially when used simultaneously with alcohol).
Ciprofloxacin should not be administered subconjunctivally or directly into the anterior chamber of the eye.
Pregnancy and lactation
Contraindicated during pregnancy and lactation.
Ciprofloxacin penetrates the placental barrier and is excreted in breast milk.
In experimental studies
It has been found to cause arthropathy.
Use in childhood
Contraindicated in children and adolescents under 15 years of age.
For impaired renal function
In patients with impaired renal function, dosage regimen adjustment is required.
The effectiveness of ciprofloxacin for angina
The drug is effective for any form of angina, but most often it is prescribed for purulent angina, accompanied by serious complications.
The tablets, regardless of the stage of the disease, demonstrate a positive effect already on the third day of treatment.
During this period, the surface of the larynx is almost completely cleaned of pathogenic microorganisms.
Important! If this happens faster, then taking ciprofloxacin should be stopped immediately, using less dangerous medications to treat residual signs of tonsillitis and for prevention.
Antibiotics for sore throat in children
Often the disease begins as a viral infection (ARVI, influenza), but then pathogenic bacteria join it and cause purulent inflammation of the tonsils, respiratory tract, nasal passages, and ears. In these cases, the prescription of antibiotics to children from 3 to 15 years of age is mandatory. Moreover, such drugs are needed not so much for the treatment of follicular or lacunar tonsillitis (tonsillitis), but to protect the child from severe damage to the joints, heart, and nervous system.
Arthritis, rheumatism, myocarditis, glomerulonephritis, and meningitis are especially dangerous. To prevent these insidious complications, you can start giving an antibiotic to a child for a sore throat not immediately, but on days 2-9 from the moment the disease develops. In this case, it is necessary to take into account the age of the children:
- For children from 1 to 3 years old, doctors prescribe antibacterial drugs when complications of the respiratory tract, throat or nose appear (purulent processes usually do not develop in them);
- children from 3 to 15 years old - even with mild follicular or lacunar tonsillitis;
- adolescents over 15 years of age if the disease causes complications of the respiratory tract, throat, ears, nose.
What antibiotics should I take for a sore throat? Medical practice shows that children tolerate medications from the penicillin, macrolide, and cephalosporin groups more easily. Tetracyclines and sulfonamide drugs should not be used. Potent drugs from the aminoglycoside group (Gentamicin, Neomycin, Monomycin), Levomycetin can be used only in severe cases when a sore throat does not go away with the help of antibiotics that have fewer side effects.
The drugs of choice are from the penicillin group. Amoxicillin (Amosin, Flemoxin Solutab), an effective remedy against many types of pyogenic bacteria, has proven itself especially well. Amoxiclav is even more in demand - a combination of Amoxicillin with clavulanic acid, which destroys enzymes that increase the resistance of pathogenic flora to antibiotics. This drug can be given to infants from 3 months. Augmentin works similarly.
How to use to treat sore throat in adults?
According to the instructions for use, treatment with this drug is only possible for adults over the age of 18 years.
It is better to take tablets an hour and a half before meals , since once in an empty stomach, such a drug dissolves and is absorbed better.
During treatment, it is advisable to avoid consuming dairy and other calcium-rich foods.
The standard course of treatment is a week , during which you need to take half a tablet three times a day.
If necessary, the course can be extended to ten days.
For purulent sore throat with complications, the course is sometimes extended to one month, and in especially severe cases, the patient is given a drip with a solution of ciprofloxacin for three to four days.
Ciprofloxacin tablets 500 mg, what helps, eye drops instructions
Ciprofloxacin is a broad-spectrum antibacterial drug that is classified as an antimicrobial agent for systemic use. Antibiotic. Release form: hard-coated tablets, eye and ear drops, injections, solution for infusion, intravenous and intramuscular ampoules, suppositories, suspension for children.
What is ciprofloxacin prescribed for, indications for use
Indications, for what, how to take:
- 1. For cystitis
- 2. For sore throat
- 3. For prostatitis
- 4. For the flu
- 5. For colds and ARVI
- 6. For sinusitis
- 7. For pyelonephritis
- 8. For otitis media
- 9. In veterinary medicine – for cats and dogs
- 10. In gynecology
- 11. For urethritis
- 12. For bronchitis
Compound
The active ingredient is ciprofloxacin INN. As well as a number of excipients, such as cellulose, potato starch, magnesium stearate, titanium dioxide, hydrochloride.
Ciprofloxacin analogues
The product has a sufficient number of substitutes, some of them are cheaper.
Analogues: lekhim, tsifran, ofloxacin, ciprolet, levofloxacin, doxycycline, promed, tinidazole, metronidazole, oithromycin, amoxilav, ceftriaxone. Taking synonymous drugs at the same time is not recommended. Brand names may vary between pharmacies. Compatibility with alcohol or whether you can drink it during the treatment period is not recommended.
Ciprofloxacin antibiotic or not?
The drug belongs to the group of broad-spectrum antibiotics. Effective against many grams of positive and negative bacteria. Widely used to treat animals with otitis. The mechanism of action has been widely studied.
Ciprofloxacin instructions for use
The dosage of the drug depends on the type of disease, as well as the weight and age of the patient. For adults with acute viral diseases, it is necessary to calculate the dose up to 500 mg 2 times a day.
In especially severe cases, you can increase the dose to 750 mg.
For older patients, a smaller amount of the drug should be taken to avoid additional stress on the heart muscle.
For children with diseases of the genitourinary system, FPO is indicated at the age of 1 to 12 years. Children who have inflammation of the respiratory system are recommended for use only from 5 years of age. The dosage is calculated depending on the child’s body weight.
Tablets 500 mg how to drink, dosage
The tablets should be taken before meals. For cystitis in women and men, take 500 mg. once a day. In complicated cases, the drug is taken 2 times a day. To prevent invasive infections, take 500 mg. per day.
Eye drops
It is a yellow antibacterial solution that is dropped into the eyes to destroy the DNA of pathogens and bacteria. Able to slow down their reproduction and growth. Accepted by the course.
Ciprofloxacin instructions for use eye drops
It is used for various eye diseases such as conjunctivitis, meibomitis, bacterial inflammation of the cornea, therapy after operations and surgical interventions, in the nose. Patients with circulatory disorders and cancer should take it with caution.
For cystitis
For cystitis, it is taken intravenously or in the form of 250 mg tablets. at a time. You should definitely consult a doctor and not self-medicate.
Is it possible during pregnancy?
The drug is contraindicated during pregnancy and lactation, as in the early stages it can cause negative effects on the fetus. Experimental studies have confirmed this. During lactation, the drug can pass into breast milk.
Ampoules intravenously, intramuscularly
Injections are used in the form of droppers and injections. The duration of treatment is up to 10 days.
For colds, flu, sinusitis
For sinusitis, 1-2 tablets will be prescribed for 7 days, depending on the course of the disease. For flu and colds, 125 mg. in one go.
Reviews about solution, tablets
The drug has a relatively mild effect on the body, regardless of the form of release. It is worth taking the pills in a course so that there is no relapse of the disease. It is mandatory to take probiotics to improve intestinal microflora, tavanik.
Contraindications
The drug is contraindicated in:
- 1. Pregnancy;
- 2. Individual intolerance to the drug;
- 3. The body's sensitivity to antibiotics.
Side effects - allergies, lethargy, depression and irritability, headache, vomiting, diarrhea, constipation, abdominal pain, hearing and vision impairment, white coating on the tongue.
How much it costs and what is better, differences, photos, recipe in Latin can be found on the official website of the manufacturer or Wikipedia, packaging.
Source: https://ProMedicine.ru/otechestvennye-lekarstva/ciprofloksacin-tabletki-po-500-mg-ot-chego-pomogayut-glaznye-kapli-instrukciya.html
Side effects
Note! When taking the drug, side effects may occur in the form of disorders and diseases:
- development of superinfection;
- nausea and vomiting;
- weakness and malaise, drowsiness;
- flatulence and diarrhea;
- stomach pain and headaches;
- severe shortness of breath;
- anorexia;
- development of depression, increased anxiety;
- insomnia;
- increased sensitivity of the visual organs to light;
- sweating;
- swelling of the larynx and face;
- increased level of intracranial pressure;
- hallucinations;
- dermatological allergenic reactions (including the formation of blisters on the skin that burst and bleed);
- visual, smell and hearing impairments;
- loss of taste;
- tachycardia;
- bloody discharge in the urine;
- interruptions in heart rhythm;
- hemolytic anemia.
This is an incomplete list of side effects, and they can develop both with increased sensitivity to the components of the tablets, and for no apparent reason.
Need to know! Ciprofloxacin is taken with the subsequent recording of the patient’s condition by a doctor, and at the first manifestations of such reactions, the drug is discontinued.
What antibiotics are prescribed for sore throat
The choice is determined primarily by the severity of the bacterial disease and the age of the patient. What antibiotics should I take for a sore throat? First-line drugs are penicillins. Medicines are characterized by increased selectivity to pathogenic microorganisms. If the patient is not allergic to penicillins, doctors give priority to them. The disadvantages of these drugs: the drugs are quickly eliminated from the body, and many strains of bacteria develop resistance to them. Doctors give preference to other medications when penicillins do not help.
Second-line drugs are cephalosporins. These drugs cause a lasting therapeutic effect against many bacteria and are used to treat many infections. If the disease is very severe, accompanied by high fever, significant swelling of the throat mucosa, cephalosporins, rather than penicillins, are immediately prescribed. If you are allergic to them, fluoroquinolones are used. Moderate sore throat is often treated with macrolides. It is better not to use tetracyclines due to the risk of severe side effects.
Antibiotics for sore throat in tablets
Antibacterial drugs are often prescribed in this form, which is convenient for outpatient treatment of tonsillitis. The following antibiotics for angina in adults in tablets are highly effective:
- penicillins - Amoxicillin, Amoxiclav, Augmentin, Ampicillin, Oxacillin, Flemoxin Solutab;
- cephalosporins - Cifran, Ceftriaxone, Cephalexin;
- fluoroquinolones – Levofloxacin, Ofloxacin, Ciprofloxacin;
- macrolides – Azithromycin, Z-factor, Sumamed, Zitrolide, Clarithromycin, Erythromycin;
- tetracyclines – Doxycycline, Macropen, etc.
Antibiotics against sore throat in injections
When treating severe forms of the disease, injections of the following drugs are used:
- Ceftriaxone, Cefazolin (cephalosporins);
- Ofloxacin, Pefloxacin (fluoroquinolones);
- Benzylpenicillin, Ampicillin, Ampiox, Oxacillin (penicillins);
- Sumamed, Erythromycin (macrolides).
Local antibiotics for the treatment of sore throat
In complex treatment of the disease, antibacterial agents must be delivered to the throat area to speed up recovery. What antibiotics are taken for local treatment for sore throat, as well as antiseptic drugs? This:
- Bioparox (Fuzafungin) - spray for irrigation of inflamed tonsils (only under the strict supervision of a doctor!);
- Tantum verde (Benzidamine) – antibacterial, anti-inflammatory spray, solution;
- Chlorophyllipt – antimicrobial lozenges, solution based on eucalyptus extract;
- Angal S (Chlorhexidine plus Lidocaine) – a spray that has a bactericidal and anesthetic effect;
- Inhalipt (Norsulfazol, Streptocide, mint and eucalyptus oils) – antimicrobial, anti-inflammatory spray;
- Miramistin - an antiseptic solution for gargling;
- Septolete Neo (Faringosept) - popular lozenges, affordable;
- Stopangin (Hexetidine) – solution, antiseptic spray;
- Orasept is an antiseptic and analgesic spray.
Source sovets.net
Reviews
“ Ciprofloxacin is a kind of drug that either helps or only worsens the condition , and if there are adverse reactions to it, it is better to never use it again.
I have no such side effects from the product, and I use it to treat various diseases.
The last time I took a course of ciprofloxacin tablets was for a sore throat, which went away in five days .”
Angelina Ostrozhskaya, Novouralsk.
“ The doctor prescribed me ciprofloxacin , and at first I was afraid to take it, because I had heard about the negative effects of the drug.
But in my case, throughout the entire treatment, I experienced only severe weakness, I constantly wanted to sleep, and I was ready to endure such a general malaise, expecting a quick positive effect.
I managed to recover in about a week , and immediately after I stopped taking these pills, the state of weakness also went away.”
Georgy Eremeev, Kamensk-Uralsky.
Recommendations for the use of the product in different dosage forms
The instructions for use of the drug Ciprofloxacin indicate that, if indicated, the drug should be used until the symptoms of the deviation completely disappear, and after that - for at least another 3 days.
Use of tablets
Ciprofloxacin tablets should be used orally, after meals. They should be swallowed whole with a small amount of liquid.
The daily dosage and duration of the therapeutic course depend on the disease identified in the patient.
- For infectious pathologies of the urinary tract, a double dose of 250-500 mg of the drug is prescribed. Duration of treatment – 7-10 days;
- for infections of the gastrointestinal tract that developed under the influence of Staphylococcus aureus, a double dose of the drug is prescribed at a dosage of 750 mg. The course of treatment is from 1 to 4 weeks;
- for chronic salmonellosis, it is recommended to take the drug twice a day, 500 mg per day. If necessary, the dosage can be increased to 750 mg. Duration of therapy – up to 4 weeks;
- for severe infections caused by staphylococci, streptococci, chlamydia, a double dose of 750 mg is prescribed. The duration of the therapeutic course is determined individually.
Note! For patients who have impaired renal function, the indicated doses are reduced by exactly half. Elderly people also reduce the dosage.
The most common and quite effective is the tablet form of the drug, which is used at the initial stage of development of the disease.
Solution for infusion, concentrate
Ciprofloxacin solution is administered intravenously into a large vein. This reduces the risk of side effects at the injection site.
The concentrate for infusion is diluted to a volume of 50 ml with infusion solutions (for example, sodium chloride solution).
The amount of solution administered also depends on the disease. For adult patients, the dosage is as follows:
- for infectious processes of the respiratory tract, 400 mg of the drug is administered 2-3 times a day;
- in case of severe infections that threaten human life (peritonitis, pneumonia, infections of bones and joints), the recommended dosage is 400 mg. Frequency of administration – 3 times a day;
- for acute uncomplicated infectious processes of the genitourinary system, 200 to 400 mg of solution is administered twice a day. For complicated infections, 400 mg of the drug is prescribed intravenously 2 to 3 times a day.
When using ear and eye drops, adhere to the following dosages:
- 1 drop in each eye 4 to 8 times a day for injuries. The course of treatment is 1-2 weeks;
- 1 drop 6 times a day for keratitis. Duration of therapy – 2-4 weeks;
- 1-2 drops 4-8 times a day for blepharitis, conjunctivitis. Duration of treatment is 5-14 days.
Note! To treat diseases of the hearing organs, 3-4 drops are instilled into the external auditory canal 2-4 times a day.
Ciprofloxacin injections are used for infections that have become complicated and require more complex treatment