Ambroxol 30 mg tablets instructions for use, LF

Indications for use of Ambroxol

Ambroxol, according to the instructions, has the following effect:

• reduces the viscosity of brochial secretions;
• sputum in the bronchi thins;
• villi are activated in the respiratory tract, which allows sputum to leave the bronchi faster.

Ambroxol promotes the production of surfactant, a protective element that is produced in the lungs and protects against tissue damage.

Syrup for oral administration has an anti-inflammatory effect and improves pulmonary metabolic processes. When it is given to children, it helps stimulate their immunity, as the production of interferon increases. Ambroxol enters the lung tissue and has a targeted effect similar to antibiotics.

Indications for use of Ambrocosol are as follows:

• bronchitis of various etymologies;
• tracheitis;
• pneumonia;
• bronchial asthma;
• tracheobronchitis;
• chronic obstructive pulmonary disease;
• bronchiectasis.

In addition, the drug is very helpful in the treatment of cystic fibrosis , a rare congenital syndrome, as well as frontal sinusitis or sinusitis, when the paranasal sinuses become inflamed. It is often prescribed for thick nasal discharge.

Medicine for sinusitis

An otolaryngologist should prescribe an effective medicine for sinusitis after examination and receipt of test results. In addition, the form of the disease and the type of pathogen are important for adequate treatment measures.

Medicines for the treatment of sinusitis:

1. Antibiotics.
2. Sulfonamides.
3. Drugs to reduce and relieve the inflammatory process.
4. Liquids for rinsing the nasal sinuses.
5. Drops and sprays for relieving swelling and draining the maxillary sinuses.
6. Solutions for inhalation.

Let's take a closer look at each group of medications.

Which antibiotic medications are used to treat sinusitis:

1. Gramox.
2. Amoxil.
3. Flemoxin solutab.
4. Hiconcil.
5. Augmentin.
6. Rovamycin.
7. Digital
8. Cephalexin.
9. Vampilox.
10. Macropen.
11. Sporidex.
12. Duracef.
13. Ampiox.
14. Cefotaxime.
15. Ceftriaxone.
16. Vertsef.
17. Cefazolin.

An antibiotic medicine for sinusitis should stop the development of the inflammatory process in the body and stop the growth and reproduction of bacteria or fungi in the sinuses of the nasal cavity. When choosing a medicine for the treatment of sinusitis, it is necessary to study the list of side effects of the medicine and the level of its toxicity.

What sulfa medications to take for sinusitis:

1. Sulfadimethoxine.
2. Biseptol.
3. Etazol.
4. Streptocide.
5. Norsulfazole.
6. Sulfalene.
7. Sulfopyridazine.
8. Sulfadimezin.

This group of drugs is prescribed for severe forms of the disease and a dangerous course of the inflammatory process in combination with an antibiotic. In addition, sulfonamide drugs can be used as replacement therapy in case of intolerance to antibiotics. When choosing which medications to take for sinusitis from a number of sulfonamides, you need to check how compatible they are with the chosen antibiotic and whether the appropriate drug causes allergic reactions.

How to treat sinusitis - anti-inflammatory drugs:

1. Coldy.
2. Flukold.
3. Coldrex.
4. Pharmacitron.
5. Coldact.
6. Loratadine.
7. Fenkarol.
8. Bromhexine.
9. Ambroxol.
10. Sinupret.
11. Sinuforte.
12. Suprastin.
13. Cinnabsin.
14. Gaymorin.
15. Solpadeine.
16. Nimid.
17. Oksalgin.
18. Bronchoclair.
19. Diazolin.
20. Tavegil.

Any of the above remedies is suitable as a cure for chronic sinusitis in complex therapy of the disease in the acute stage. They also perform the following functions:

• enhance the effect of antibiotics;
• reduce swelling of the nasal mucosa;
• relieve headaches;
• reduce inflammation in the sinuses;
• contribute to the dilution of purulent contents.

Medicinal liquids for rinsing the sinuses:

1. Tincture of calendula.
2. Elekasol.
3. Rekutan.
4. Saline solution.
5. Phytodent.
6. Rotokan.
7. Chamomile decoction.
8. Decamethoxin.
9. Manganese solution.
10. Furacilin.
11. St. John's wort decoction.
12. Iodine solution.

Medicine for sinusitis - spray:

1. Isofra.
2. Xylo-Mepha.
3. Sinuforte.
4. Aqualor.
5. Xymelin.
6. Humer.
7. Sanorin.
8. Marimer.
9. Otrivin.
10. Nazaval.

Solutions and medications for inhalation for sinusitis:

1. Herbal anti-inflammatory decoctions:

• chamomile;
• series;
• St. John's wort;
• Oak bark;
• celandine;
• currant leaves.

2. Inhalation solutions with essential oils:

1. Brine.
2. Dioxidin with saline solution in equal proportions.
3. Berodual.
4. Salgim.
5. Berotek.
6. Atrovent.
7. Ventolin Nebula.
8. Gedelix.
9. Tonsilgon N.
10. Cromohexal.
11. Pulmicort.

The use of Ambroxol for the treatment of children

Instructions for the use of Ambroxol in the form of syrup for oral administration provide for its use by children under one year of age, but this should only be done under the supervision of a pediatrician . It is he who must calculate a certain dosage, which depends on the symptoms and weight of the child. Once opened, the syrup is stored at temperatures up to 15 degrees for a month.

Very often this remedy is prescribed to premature babies for preventive purposes. It stimulates the production of surfactant and prevents the development of distress syndrome in such babies.

Medicine Abroxol: instructions for use

Pills

Ambroxol hydrochloride capsules are intended for oral administration. They should be taken with a small amount of liquid. The recommended dose for adult patients and children over the age of twelve is 30 mg (one tablet). Frequency of doses – 2 (if necessary, the drug can be taken 3 times a day).

In case of exacerbation of chronic diseases, the dose of Ambroxol in tablets is doubled (up to 60 mg). The frequency of doses is 2 times a day. Cough tablets are used to treat children over six years of age. The therapeutic dose for children from six to twelve years of age is from 1.2 to 1.6 mg/kg/day in 3 divided doses.

The duration of treatment is determined individually depending on the severity of the disease and the patient’s response to therapy. As a rule, it ranges from 10 to 14 days.

Ambroxol syrup: instructions for use

For all categories of patients over twelve years of age, during the first 2-3 days of the disease, the recommended dose is 10 ml (equivalent to the volume of two teaspoons). Then the treatment is continued, taking the syrup 3 times a day. 5 ml (equivalent to the volume of one teaspoon).

Syrup for children is dosed depending on the age of the child. Thus, children aged five to twelve years are recommended to take 5 ml of syrup (30 mg of active ingredient per day) 2 times a day. If necessary, the frequency of doses is increased to 3 (the daily dose of ambroxol in this case is 45 mg).

Children aged two to six years are prescribed to take 2.5 ml of syrup 3 times a day; children under two years old - 2.5 ml of syrup 2 times a day. This is equivalent to 22.5 and 15 mg of active ingredient per day, respectively. If the patient is indicated for long-term treatment, the dose may be halved.

Dosage regimen of Abroxol for inhalation, as well as solution for injection and infusion

Adult patients are prescribed one or two inhalations per day using 3 ml of inhalation solution; Children over 5 years of age are recommended to take one inhalation per day using 2 ml of solution (equivalent to 15 mg of the active substance).

If the drug is prescribed as an injection solution, the optimal dose for an adult patient is 30 to 60 mg/day. It is divided into three introductions. The maximum single dose is 30 mg.

Typically, the solution is injected into a vein or muscle, although subcutaneous administration is also acceptable. For shock lung syndrome, the dose of ambroxol is 10 mg/kg/day. The drug should be administered 3 or 4 times a day. In cases where it is appropriate, the daily dose is increased to 30 mg/kg. It is administered in 3-4 doses.

Ambroxol analogs

Ambroxol as an active ingredient is present in many drugs. In particular, we will return to Ambrobene in the form of a solution for inhalation and other forms.

As for other drugs that have a similar effect, here is their description:

• Lazolvan - presented in the form of syrup, solution or lozenges. Has similar indications for use. Syrup and solution can be given to children from birth, lozenges - only from 6 years of age;
• Ambrogesal - comes in the form of tablets, solution, syrup and capsules. Syrup and solution can be prescribed to children from birth, tablets only from 6 years of age, and capsules to adults and children from 12 years of age;
• Flavamed - available in the form of tablets or solution. The oral solution is prescribed to children from birth, tablets - from 6 years;
• ACC – the active substance is acetylcysteine. It comes in the form of syrup, solution granules and effervescent tablets. Can be given to children from 2 years old;
• Bronchicum S - this product is in the form of a syrup and has a natural base. It is made from liquid thyme extract. It is prescribed for inflammatory diseases of the upper respiratory tract, which are accompanied by cough and problematic sputum production. Prescribed for adults and children from six months.

Contraindications

• Individual intolerance to certain elements of the drug that cause allergies;
• First trimester of pregnancy (there is a risk of negative effects on the fetus, penetration through the amniotic membrane);
• Impossibility of fructose breakdown due to inferior microflora of the digestive system;
• Ulcer of the duodenum, gastric system (accelerated disruption of cell structure due to a decrease in the protective functions of the organ mucosa);
• Liver failure;
• Inflammation of the kidneys (acute or chronic);
• Development of seizures;
• Problems with carbon metabolism;

Prescribed with caution to pregnant women in the later stages (2-3 trimester) and during lactation. In this case, doctor's recommendations are required.

When prescribing a course of treatment, it is necessary to analyze the therapy for the mother’s body and identify the negative effects on the fetus or baby. The use of any form of Ambroxol suspension is only after examination by a specialist.

Ambrobene: solution for oral administration and inhalation and other forms

Ambrobene is based on ambroxol hydrochloride . It helps stimulate mucus thinning and promotes expectoration. The action begins within a few minutes after application. It is similar to what was described above in relation to Ambroxol.

Absorption of the drug occurs from the gastrointestinal tract. It is predominantly excreted through the kidneys.

Ambrobene, like Ambroxol, has different dosage forms, which are prescribed by a doctor depending on the symptoms, disease and age. So, when prescribing treatment for children, the pediatrician must examine the child. If he suffers from a dry cough, he is prescribed an oral syrup that has a pleasant aroma.

The syrup should be drunk half an hour after eating, and be sure to drink plenty of fluids when taking it. The last time you should take the drug is two hours before bedtime, so that the process of active sputum production does not occur during sleep.

The solution for oral administration should be drunk after meals; it is added in the required dosage to the liquid .

For premature babies there is a special form of Ambrobene - an injection solution, which is prescribed for respiratory failure. It is administered subcutaneously, intravenously or intramuscularly along with a solvent, most often sodium chloride.

The duration of treatment is about 5 days. If during this time the cough does not go away, or even worsens, you should consult a doctor.

Inhalations

Ambrobene is often used in solution form to treat respiratory diseases. The solution is used the same as for internal use. Inhalations are effective in the treatment of bronchial asthma, obstructive bronchitis or bronchiectasis.

Inhalations based on Ambroxol have the following effect:

• the active substance penetrates very quickly into the mucous membranes of the bronchi;
• the risk of side effects is minimized;
• in the complex treatment of a particular disease, the dosage of antibacterial medications can be reduced.

A nebulizer is often used for inhalation, with its help the Ambrobene solution is converted into an aerosol, it is able to penetrate into hard-to-reach parts of the bronchi or lungs. This type of therapy can be performed both in hospital and at home.

Before use, the solution is diluted with saline solution of sodium chloride in a ratio of one to one. It is then warmed to body temperature . The product is inhaled through a mask or through a special breathing tube with a mouthpiece.

If such procedures are prescribed to children under 2 years of age, they should be carried out under the strict supervision of a specialist and only as prescribed. Depending on age or disease, inhalations with ambroxol are carried out 1 or 2 times a day.

Features of application

Ambroxol can be used for inhalation in a nebulizer with a compressor or ultrasonic aerosol supply. Do not use the drug in steam inhalers or any other heated devices.

Before starting the procedure, the liquid should be mixed in equal proportions with a 0.9% sodium chloride solution. The optimal temperature of the drug for inhalation should be 30-35 °C.

1-2 inhalations per day are allowed with an interval of at least 12 hours. The course of treatment is 4-5 days; if necessary, an increase in the duration of therapy should be agreed with the doctor. The volume of the drug solution used per procedure depending on the patient’s age:

• Children under 6 years old – no more than 2 ml.
• Children over 6 years old and adults – 2-3 ml.

Inhalation procedure:

1. Thoroughly rinse and dry all removable parts of the device (nebulizer chamber, air tube, mask or mouthpiece). Assemble the inhaler, plug it in and make sure it is working.
2. Using a sterile syringe, pipette or measuring cup, measure the required amount of a pre-prepared solution of Ambroxol in 0.9% sodium chloride. Pour the drug into the nebulizer chamber, close the lid and check the tightness of all connections.
3. Turn on the air supply. Inhale the resulting aerosol using a suitable size mask or mouthpiece placed on the top valve of the nebulizer chamber. To avoid the development of side effects (spasms, increased intensity of cough), breathe as usual, trying not to take too deep a breath.

During the procedure, the child must be in the arms of an adult. It is necessary to monitor his condition and respiratory rate. The duration of inhalation in children should not exceed 2-3 minutes.

1. Dispose of any remaining medication from the nebulizer chamber, rinse thoroughly with running water and soap, and air-dry all removable parts of the device.

Side effects

Ambroxol, Ambrobene and other drugs that have a similar effect may have side effects . Some of them occur frequently, others less frequently, and some in isolated cases.

Let's look at them in detail:

• immune system – hypersensitivity and anaphylactic reactions such as urticaria, rash, itching, angioedema or anaphylactic shock may not develop very often;
• nervous system – often there is a violation of taste;
• Gastrointestinal organs - often the use of the drug results in nausea, less often - the appearance of dry mucous membranes of the throat and mouth, dyspepsia, abdominal pain, vomiting or diarrhea.

Side effects

Ambroxol is usually well tolerated. But in some cases of taking the drug, side effects are possible:

• allergic reactions (allergic dermatitis, urticaria, skin rash, anaphylactic shock and, sometimes, angioedema);
• dysuria, diarrhea, constipation;
• headache, rhinorrhea;
• exanthema, dry mouth and respiratory tract.

Long-term use of Ambroxol in high doses is not recommended, as this can cause unwanted side effects such as nausea, vomiting, gastralgia, and deterioration of intestinal function. Rapid intravenous administration in some cases contributes to the appearance of chills, hyperthermia, shortness of breath, decreased blood pressure, intense headaches, adynamia, and a feeling of numbness.

Overdose symptoms

As for overdose with ambroxol-based drugs, signs of intoxication have not been identified in clinical studies. Sometimes diarrhea and nervous agitation may occur. Thus, the drug is generally well tolerated at a dosage of up to 25 mg/kg per day.

If the overdose was severe, it may manifest itself in the following symptoms:

• blood pressure decreases;
• nausea;
• vomit;
• salivation increases.

Treatment of overdose in severe forms consists of intensive care. The patient's stomach is washed and vomiting is induced; this should be done in the first hours after using the product.

Use with other drugs and other instructions

If ambroxol-based drugs are taken together with other cough remedies due to suppression of the cough reflex, this can cause stagnation of secretions . In this case, you need to be extremely careful in choosing certain drugs for complex therapy.

Also remember that if you take ambroxol along with the antibiotics doxycycline, cefuroxime, erythromycin or amoxicillin, their concentration in bronchial secretions or sputum increases.

In addition, ambroxol should not be given to children under 2 years of age without first consulting a doctor. In rare cases, the use of the product in one form or another may trigger the development of skin reactions such as Lyell's or Stevens-Johnson syndrome. If this occurs, discontinue the drug and consult a doctor.

are prescribed even to small children in the form of oral solutions, inhalations or syrups . However, it is very important to consult a doctor before using this remedy.

Ambroxol Hcl CAS 18683-91-5 Ambroxol Hydrochloride CAS 23828-92-4

Ambroxol Hcl CAS 18683-91-5 Ambroxol Hydrochloride CAS 23828-92-4

Keywords: Ambroxol Hcl, ambroxol hydrochloride, ambroxol powder API, raw materials

Applications of ambroxol base and ambroxol Hcl: Cough and phlegm

Description and use: Ambroxol hydrochloride or ambroxol Hcl is a bronchosecretory drug. This is a secret active substance that will treat diseases associated with sticky or excessive mucus. Ambroxol hydrochloride is the active ingredient of Ambroxol hydrochloride and ambroxol Hcl is a mucoactive drug. It has several properties such as secretolytic and secretory actions that restore the physiological mechanisms of airway clearance. It plays an important role in the body's natural defense mechanisms. Ambroxol hydrochloride and ambroxol Hcl are often administered as the active ingredient in cough syrups or some oral solutions. Ambroxol hydrochloride and ambroxol Hcl help clear mucus, facilitate expectoration and relieve productive coughs. This will help patients breathe freely and deeply. Ambroxol hydrochloride tablets or pills, dry powder sachets are also available at most pharmacies. Ambroxol also causes a sore throat. The local anesthetic effect allows ambroxol hydrochloride and ambroxol Hcl to treat sore throat. In addition, Ambroxol Hcl is a potent inhibitor of neuronal Na + channels.

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Ambroxol Hcl CAS 18683-91-5 Ambroxol hydrochloride is a clinically proven systemically active mucolytic agent. When administered orally, the onset of action occurs within approximately 30 minutes. The destruction of acidic mucopolysaccharide fibers makes sputum thinner and less viscous and therefore easier to clear when coughing. Although the volume of sputum eventually decreases, the viscosity of Ambroxol Hcl CAS 18683-91-5 Ambroxol Hydrochloride remains low as long as treatment is maintained.

Indications for ambroxol Hcl, ambroxol hydrochloride:

Ambroxol Hcl, ambroxol hydrochloride Raw materials, API indicates almost all forms of tracheobronchitis, emphysema with bronchitis, pneumoconiosis, chronic inflammatory lung diseases, bronchiectasis, bronchitis with bronchospasm, asthma. During acute exacerbations of bronchitis, Ambroxol Hcl, ambroxol hydrochloride raw material, API should be taken along with an appropriate antibiotic.

Side Effects of Ambroxol Hcl, Ambroxol Hydrochloride Raw Materials, API:

Gastrointestinal side effects may occasionally occur, but they are usually mild.

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Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API is a medicine indicated for the relief of chest congestion associated with conditions such as bronchitis, pneumonia and bronchospasm. Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API is part of a class of drugs called mucolytics and functions by thinning breast mucus in affected individuals. Although Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API is not currently sold in the United States, it is widely available in most other countries in the world.

As a professional Chinese Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API supplier and manufacturer in China, FENGCHEN GROUP CO., LTD has been supplying and exporting Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API from China to China for almost 10 years.

Metabolism:

Studies in human liver microsomes have shown that CYP3A4 is the predominant isoform for ambroxol metabolism. Otherwise, Ambroxol Hcl, ambroxol hydrochloride, API is metabolized in the liver primarily by conjugation.

Remedy:

Approximately thirty percent of Ambroxol Hcl, Ambroxol whey material, API will be removed using the first pass effect. The terminal half-life is approximately 600 minutes.

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General description and applications:

Ambroxol Hcl, ambroxol hydrochloride Raw Material, API is a metabolite of bromhexine. It is an expectorant improver and mucolytic agent used in the treatment of acute and chronic diseases characterized by the production of excess or thick mucus. Ambroxol Hcl, Ambroxol Hydrochloride Raw Material, API works to reduce the viscosity of mucus by changing its structure. It is chemically described as trans-4 - ((2-amino-3,5-dibromobenzyl) amino) cyclohexanol. Ambroxol Hcl, ambroxol hydrochloride Raw Materials, API - white to yellowish crystalline powder; slightly soluble in water, ethanol; soluble in dimethylformamide, methanol; insoluble in chloroform and benzene; melting point 240 ° C; administered orally.

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Indexes of ambroxol hydrochloride or ambroxol Hcl:

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