ACC or Sinekod: comparison and which medication is better?

Treatment of acute and chronic respiratory diseases is symptomatic, and in case of increased viscosity of secretions, Fluditec or Ascoril are prescribed, which better help the discharge of mucus. Cough is the most common debilitating symptom, but is not a separate disease. Treatment should be directed against the virus, bacteria or immune system reaction that causes inflammation and mucus buildup in the airways. Mucus produced in excess can impair breathing, although it is a protective mechanism. The goal of treatment is to optimize the cough—to quickly clear sputum.

Mechanisms of action of Ascoril

Ascoril is a combination drug that allows you to quickly improve breathing in diseases of the respiratory tract with viscous sputum. The effect of the substances is addressed primarily to bronchial asthma with spasm and difficulty breathing.

The composition includes three products:

1. Ambroxol, which thins and softens mucus, makes it easier to cough up. That is why the drug is used only for wet coughs with the formation of viscous secretions.
2. Levosalbutamol is used in the treatment of asthma and chronic obstructive pulmonary diseases, it relaxes the muscles on the walls of the airways, making breathing easier.
3. Guaifenesin is an anxiolytic that increases mucus production and affects the adhesiveness of respiratory tract secretions.

Ambroxol belongs to the class of expectorants or mucolytics. Levosalbutamol is a beta-agonist that relaxes the muscles in the walls of the airways, helping patients with reversible obstructive diseases.

It is recommended to take for the following serious diseases:

• bronchial asthma;
• Chronical bronchitis.

The drug is not recommended for use for colds, ARVI, which are not complicated by bronchitis or pneumonia.

Mechanisms of action of Fluditec

This expectorant and anti-inflammatory syrup is based on the substance carbocisteine ​​with multiple effects.

• headache;
• sleep disturbance;
• vomiting and diarrhea;
• increased heart rate.

Compared to Ascoril, Fluditek has fewer contraindications; the instructions provide for long-term dosage regimens:

• up to 30 days for chronic bronchitis and asthma;
• courses for 4 days with a break of up to 8 days.

Fluditec is not combined with other cough suppressants, its effect is reduced, but it independently copes with a lingering cough, alleviating the patient’s condition.

The advantage of the drug is that it relieves coughs that occur in chronic conditions:

• postnasal drip with adenoids;
• chronic sinusitis with the release of purulent contents of the sinuses.

These conditions provoke a lingering cough that occurs at night and is difficult to diagnose. The course of treatment with Ascoril does not exceed 5-7 days, and therefore it is prescribed for the rapid relief of complex conditions associated with the formation of viscous mucus and stagnation. The only restriction is the inability to take the substance in tablets for children under 6 years of age. The advantage of the syrup formula is menthol, which contains essential oils. Thanks to this, the product has a calming, antispasmodic and antiseptic effect. Since the drug stimulates the production of cell surfactant, it should be used in the acute phase of the disease. Ascoril improves the passage of antibiotics into the lung tissue, therefore it is useful for inflammation.

Hospital-based research is being conducted on the effectiveness of the drugs, focusing on the effectiveness and safety of over-the-counter cough syrups.

Ascoril was compared with another expectorant in a study in Mumbai. Patients with various respiratory diseases were divided into two groups according to the drugs.

Efficiency was assessed using three indicators:

• cough;
• sputum;
• dyspnea.

The course of treatment lasted up to approximately 14 days, and doctors also assessed the tolerability of therapy. The improvement and reduction of symptoms was immediate and faster than in the other expectorant group. In terms of effectiveness, 96% of doctors highly rated Ascoril. An increase in lung volume function was recorded.

In 2005, Russian scientists evaluated the effectiveness of Fluditec on 58 children aged 3-8 years with infectious rhinitis and adenoiditis.

The patients were divided into two groups:

• Fluditec was given first;
• the second was prescribed nasal irrigation with antibacterial agents and inhalations.

Scientists not only examined children regularly, but also conducted a cytological study of nasal mucus. Approximately 70% of study participants had cough and breathing problems due to the accumulation of nasal secretions. In the Fluditec group, sputum discharge improved already on the third day of treatment, and on the fourth day its quantity began to decrease. The cough in almost 90% of children decreased and disappeared after a week of therapy. In the group with nasal rinsing, changes began only on the sixth day, and after a week, nasal secretions began to decrease.

The existing large selection of expectorants and mucolytic drugs often puts the patient in a dilemma: which drug should be taken to relieve cough.

Similar in mechanism of action and indications, each drug differs in the specificity of action and has its own characteristics.

Fluditek

Belongs to the group of synthetic mucolytic agents. The main active ingredient is carbocysteine.

It is produced in the form of a medicine (syrup) for use in adults and children, differing in the concentration of the active substance. Among the auxiliary components, it contains dyes that provide the orange color of the mixture for children's use, and green for adult patients.

The pharmaceutical industry produces another analogue, with carbocysteine ​​salt as the active ingredient - Fluifort.

Mechanism of action

The therapeutic effects provided are due to the special mechanism of interaction of carbocisteine ​​with the bronchial epithelium.

When taken orally:

1. Helps increase the secretion of bronchial glands.
2. Makes sputum less viscous, diluting it due to the destruction of the sulfhydryl bonds of the latter.
3. It influences enzymes produced by bronchial goblet cells and participates in the regulation of their number.
4. Promotes changes in the rheological properties of mucus.
5. Restores the structure of the bronchial epithelium, regulates its production of immunoglobulin A.

The effectiveness of the product lasts for 8 hours from the moment of administration.

Indications

It is used as a symptomatic and auxiliary treatment for diseases accompanied by the separation of thick sputum, mucus, and as an expectorant. Indicated for:

• Inflammatory processes of all parts of the respiratory tract - laryngitis, tracheitis, bronchitis, regardless of the cause of the disease.
• Pneumonia of various etiologies.
• Bronchial asthma.
• Sinusitis.
• Inflammatory diseases of the middle ear, eustachitis.
• As a means for preparing and conducting instrumental methods for examining the bronchi, ENT organs, and x-ray diagnostics.

Fluditec is an effective remedy that can be prescribed for any pathological process accompanied by a cough with thick, difficult to separate sputum in infants and adults.

Contraindications

The use of the drug is not indicated:

• During pregnancy, especially the first three months, while breastfeeding. If there is a need to take Fluditec during lactation, it is recommended to stop breastfeeding.
• For acute gastric and duodenal ulcers.
• The drug should not be taken against the background of acute severe pathological changes in the kidneys or liver.
• Use is contraindicated if you are allergic to components that are components of the medicine.

Use in later stages of pregnancy is possible only after weighing all possible risks and as prescribed by a doctor.

Adverse reactions

When taking Fluditec, adverse reactions manifest themselves mainly in the form of:

• Allergies - possible rash, Quincke's edema.
• Disturbances from the stomach and intestines - in the form of vomiting, nausea, diarrhea, gastric pain syndrome, possible development of bleeding from the gastrointestinal tract.
• Weakness, dizziness, and headache are rarely observed.

Due to the fact that the drug contains sucrose, special attention is required when prescribing it to patients suffering from diabetes mellitus and impaired glucose tolerance.

Recommendations for admission

If the recommended doses are followed, it is well tolerated.

Due to the possibility of overdose and the development of undesirable reactions, the prescribed single and daily doses of the drug should not be exceeded, especially when prescribing the drug to young children.

Synchronous use of the drug with antibacterial drugs increases the effectiveness of Fluditec.

Ascoril

A combined three-component drug that belongs to the group of expectorants. Contains salbutamol, bromhexine, guaifenesin.

Produced in tablet form for adults, syrup for children.

Mechanism of action

The effectiveness of the drug is due to the summation of the effects of the three active components included in its composition:

1. Salbutamol is a bronchodilator that improves blood supply to the bronchial tree, prevents the occurrence of bronchospasm, and affects the diameter of the lumen of the coronary vessels.
2. Bromhexine - has a stimulating effect on the ciliated epithelium of the bronchi, makes thick sputum less viscous, and facilitates its release.
3. Thanks to Guaifenesin, the viscous secretion is liquefied and removed through stimulation of a special bronchial apparatus.

Salbutamol and Bromhexine differ in their ability to overcome the placental barrier.

Indications

Prescribed for lung diseases accompanied by an unproductive dry cough or difficult to expectorate sputum.

Contraindications

What distinguishes Ascoril from Fluditec is a wider list of conditions when it cannot be used. Contraindications for use:

• Allergic reactions.
• Severe heart diseases, manifested by functional failure, heart defects.
• Signs of kidney and liver failure.
• Diseases with manifestations of thyrotoxicosis, diabetes.
• Peptic ulcer disease.

Taking the drug is strictly prohibited for children under one year of age, during pregnancy or breastfeeding.

Side effects

Violation of the dosage regimen may lead to undesirable reactions:

• Symptoms of dyspepsia: nausea, vomiting, diarrhea.
• State of excitement, sleep disturbances.
• Cardiac arrhythmias.
• Manifestations of allergic reactions.
• Bronchospastic conditions.

The drug should not be taken with alkaline drinks.

ACC

Another effective means of combating cough, accompanied by difficulty in sputum discharge. The main active substance is acetylcysteine, which has a mucolytic effect.

It is produced in granular form for the production of syrup, in soluble tablets, and in powder for preparing a solution.

Features of the mechanism of action

In addition to mucolytic, it has antioxidant effects due to its ability to bind to free radicals. This mechanism determines the protective effect of ACC on the mucous membrane of the bronchial tree against the background of inflammation.

Indications

Prescribed to relieve cough with thick sputum. The range of pathological conditions for which ACC is prescribed is the same as that of Fluditec or Ascoril.

Contraindications

The list of conditions for which the drug is contraindicated does not differ from drugs from the mucolytic group.

Not used during pregnancy and lactation.

Features of application

When taking ACC, the following important factors should be considered:

1. It is not recommended to take the drug immediately before bedtime. The best time is at least 2 hours before a night's rest.
2. The use of ACC by patients suffering from bronchial asthma should be monitored by the attending physician.
3. When using it, it is important to dissolve the powder or tablet in a glass container, avoiding contact with metal objects that are easily oxidized.
4. Not prescribed for children under two years of age.
5. When taken simultaneously with cephalosporin antibiotics, tetracyclines, penicillins, it can reduce the activity of the latter. Therefore, you should increase the interval between taking antibacterial agents and ACC for at least two hours.
6. It is not recommended to use simultaneously with drugs that suppress the cough reflex due to the possibility of bronchial obstruction with sputum.

Comparison of the safety of Fluditec and Codelac bronchi

The safety of a drug includes many factors.

At the same time, in Codelac the bronchi is higher than in Fluditec. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Codelac bronchus, as well as Fluditec, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Codelac bronchi has fewer risks when used than Fluditec.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Codelac Bronchi and Fluditec.

Ambroxol

Available under various names: Ambrokosol or Ambrobene, or Lazolvan.

Mucolytic and expectorant agents, which contain the active ingredient ambroxol.

According to the mechanism of action, indications, contraindications, it is identical to the drugs already discussed above. Various release forms allow the drug to be used in patients of all age groups.

It is not recommended to take during pregnancy or lactation.

What to choose?

A question that often arises is a matter of choice: Should Ascoril or Fluditec be taken to treat a cough, Lazolvan or Fluifort. Let's try to systematize the information received about the drugs and answer the question of which one to give preference to - Fluditec or Ascoril and which is better:

• These medications are used to relieve cough with phlegm, helping to thin it out and make it easier to cough up.
• They have similar indications and contraindications.
• Ascoril is a combination drug representing “three in one”. A fairly effective remedy, but with limitations in use.
• Lazolvan, Ambroxol, Ambrobene are analogues.

In matters of choice, there are aspects that need to be taken into account before starting treatment:

1. For each of the indicated drugs there is a list of indications, contraindications, interaction features, and restrictions. Among them, it is impossible to choose the “best-acting” medicine. It is impossible to say unequivocally which drug, Fluditek or Ascoril, or Lazolvan is better and more effective.
2. Before taking the product, you must carefully read the instructions.
3. During administration, strictly adhere to the recommendations for doses, duration, and frequency of administration.
4. Although these drugs are available for sale without a prescription, you should not decide on your own which one to choose.

Before using the medicine, you should consult your doctor.

A wet cough with sputum is preferable to a dry cough, but it still causes a lot of discomfort. To combat this symptom, Fluditec is often prescribed. It belongs to mucolytic drugs with an expectorant effect and is available in a single dosage form of syrup. Due to the tendency to allergic reactions, Fluditek is not suitable for everyone - analogues of the drug exist, but not every drug produces the same powerful therapeutic effect.

What can replace Fluditec?

The described mucolytic is based on one active ingredient - carbocisteine. This substance has a dual effect:

• increased activity of epithelial cilia, due to which viscous sputum is more quickly evacuated from the lungs and bronchi;
• thinning mucus and reducing its production.

Drugs similar in composition are:

• Broncathar;
• Mucosol;
• Bronchobos;
• Mucodin;
• Langes;
• Mucopront;
• Carbocysteine;
• Mukolik.

Fluifort is also considered very close in this regard; it is based on carbocisteine ​​lysine salt monohydrate. Therefore, the question of which is better - Fluifort or Fluditek is inappropriate; these drugs are almost completely identical to each other.

Regarding the mechanism of action and effectiveness, there are the following popular analogues of Fluditec:

• Erespal;
• Lazolvan;
• Ascoril;
• Mukonex;
• ACC;
• Ambrobene;
• Bromhexine;
• Ambroxol;
• Ingamist;
• Bronchoval;
• Pectolvan C;
• Solvin;
• Ambrolitin;
• Cofacin;
• Medox;
• Erdomed;
• Flavamed;
• Acysteine;
• Lazolex.

Most of them are almost identical to each other, so we will consider only some well-proven medications.

Which is better - Erespal or Fluditek?

The first drug indicated is based on fenspiride hydrochloride. This compound reduces the production of secretions by the bronchi, effectively thins mucus and promotes its rapid elimination, and prevents the development of obstruction.

A special feature of Erespal is its anti-inflammatory and antispasmodic activity. Therefore, this medicine is considered more effective and preferable, especially for infectious diseases caused by coccal bacteria.

Fluditek or Lazolvan – which is better?

Lazolvan contains ambroxol hydrochloride, a substance that increases the activity of the bronchi. This effect of the drug helps speed up the evacuation of sputum and relieve coughing attacks.

At the same time, Lazolvan produces a soft, cumulative effect. Regular use of the medicine for 1.5-2 months allows you to avoid relapses of chronic lung pathologies and reduce the duration of antibiotic therapy.

It is difficult to compare the two agents under consideration, since they have different mechanisms of action. Fluditec reduces mucus production, while Lazolvan, on the contrary, stimulates it. Thus, when choosing from these drugs, you need to pay attention to the nature, intensity and productivity of the cough.

When figuring out which is better – Ambrobene or Fluditec, you can come to identical conclusions. Ambrobene also consists of ambroxol hydrochloride, and in the same concentration as in Lazolvan.

What will help better - Ascoril or Fluditek?

Ascoril is a combination medication containing guaifenesin, salbutamol sulfate, bromhexine hydrochloride. This combination causes a triple effect of the drug:

• mucolytic;
• bronchodilator;
• expectorant.

Of course, Ascoril is considered a more effective medicine than Fluditec, since it can be used to treat both wet and dry non-productive cough.

Which works better - Fluditec or ACC?

The mucolytic in the form of effervescent tablets ACC is based on acetylcysteine, which has the only function of liquefying sputum and changing its rheological properties. However, the drug effectively promotes the evacuation of secretions from the bronchi and can even be used as a prophylaxis.

In terms of effectiveness, Fluditec and ACC are approximately the same, but the latter medication is slightly better tolerated.

Ascoril is a combination drug that is used in the treatment of coughs and colds. It exhibits bronchodilating, mucolytic, expectorant activity.

Thanks to the content of salbutamol, bromhexine, guaifenesin and menthol, the syrup effectively and quickly relieves dysfunction of the bronchopulmonary system.

Causes/treatments/types of cough, and which doctor should I contact?

When choosing between lozalvan or codelac broncho, you first need to find out the causes and type of cough.

It is divided into :

1. Dry cough. With this type, there is no phlegm, it is difficult and dry to breathe. There is a constant feeling of dryness in the mouth, while the throat burns and prevents drinking normally. Bronchial mucus, which washes the membrane, is not produced.
2. Moist cough. It is considered a less unpleasant form. Sputum is released, and bronchial mucus begins to be coughed up. A wet cough is the first step to recovery after severe respiratory illness.

Causes:

• Colds and viral diseases due to hypothermia.
• Severe respiratory tract diseases due to caught infections.
• Occurs after long walks in inappropriate clothing during the winter season.

Who should I contact?

• An ENT specialist or therapist will help you cope and prescribe the necessary, safe medications.

Do not self-medicate. Do not delay the treatment process, because a normal cough can develop into a serious illness. Remember this and do not risk your health.

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pharmachologic effect

The mechanism of action of the drug is due to the combined composition. Thus, salbutamol is a selective stimulator of β2-adrenergic receptors, which helps to expand the lumen of the bronchi.

At the dose used in Ascoril (20 mg per 100 ml), it does not affect cardiac activity. Bromhexine hydrochloride reduces the viscosity of pulmonary secretions and promotes their discharge.

Guaifenesin stimulates the process of relaxation and cleansing of exudate from the bronchi, facilitating expectoration. Menthol eliminates symptoms of irritation and inflammation of the mucous membranes of the respiratory tract.

Indications for use and dosage

The instructions for use state that ascoril is indicated as part of secretolytic therapy for respiratory diseases accompanied by bronchospasm and the formation of viscous sputum, which is difficult to separate.

Such ailments include tracheobronchitis, bronchial asthma, pulmonary emphysema, cystic fibrosis, pulmonary tuberculosis, which is accompanied by the formation of sputum and attacks of suffocation, pleurisy, pleuropneumonia, bronchopneumonia, pneumoconiosis, whooping cough (with a clogging paroxysmal cough, sometimes turning into vomiting).

Ascoril is not an antibiotic, however, due to the salbutamol content, the drug should be taken as directed and under the supervision of a doctor, especially in pediatric practice.

For adolescents over 12 years of age and adult patients, the daily dose is 30 ml of syrup, divided into 3 doses.

For children from 6 to 12 years old, it is recommended that 15-30 ml of the drug be divided into 3 doses.

A more accurate dose is calculated by the doctor taking into account the child’s weight. Children from 2 to 6 years old – 1 tsp. 3 times a day.

The tablets are used in the treatment of children from 6 years of age and adults: over 12 years of age, a tablet is recommended 3 times a day, from 6 to 12 - 1 tablet. twice a day.

The duration of therapy is set by the attending physician, who will take into account the severity of the disease and its symptoms.

Comparison of addiction between Fluditec and Codelac bronchi

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “o syndrome” in Fluditec is quite similar to the similar values ​​in Codelac bronchus. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Fluditec has a fairly low incidence of “syndrome”, just like Codelac bronchus.

Contraindications and side effects

Ascoril is not used if there is a history of hypersensitivity to salbutamol and sympathomimetics, bromhexine and other main and auxiliary components of the drug.

It is also prohibited for patients with arrhythmia, severe cardiovascular pathologies, hyperthyroidism, liver dysfunction, gastric ulcer and/or duodenal ulcer, pregnant women and women during lactation to take the syrup.

According to reviews, when taking Ascoril, side effects may develop from:

• immune system in the form of rashes, skin itching, anaphylactic reactions, erythema multiforme, Stevens-Johnson syndrome, facial edema;
• Gastrointestinal organs: dyspeptic disorders, nausea, vomiting, diarrhea, pain in the epigastric region, exacerbation of gastric ulcer, unpleasant taste in the mouth;
• nervous system: tremor, myalgia, migraine, hyperactivity, insomnia, dizziness;
• cardiovascular system: tachycardia, heart rhythm disturbances, decrease/increase in blood pressure, myocardial ischemia;
• respiratory system: shortness of breath, increased coughing, paradoxical bronchospasm;
• convulsions, increased body temperature, constriction of the pupils, hypokalemia.

List of analogues cheaper than Ascoril

Ascoril is available in two dosage forms:

1. syrup, fl. 100 ml - 350 rub;
2. tablets No. 20 - 375 rub.

Analogs of Ascoril, regardless of price, should provide the closest possible therapeutic effect. In any case, the doctor is required to select a similar drug.

Most often, it is recommended to replace the original Ascoril with medications such as:

• Erespal, syrup 2 mg/ml 150 ml – 250 rubles, tab. No. 30 – 425 rub;
• Ambroxol, sir. 100 ml (domestic manufacturer) – 120 rubles, tab. No. 20 – 50 rub.;
• Stoptussin, syrup - 250 rubles, tab. No. 20 – 199;
• Lazolvan, sir. 15 mg/ml, 100 ml – 210 rubles, tab. No. 20 – 165;
• Doctor Mom, sir. 150 ml – 165 rubles;
• Ambrobene, sir. 15 mg/ml 100 ml – 148 rub.

Cheaper structural analogues of Ascoril, which have an identical composition, include: “Kashnol” syrup (170 rubles), “Joset” syrup (185 rubles). These drugs are made in India, and their cost is significantly lower than the original.

What substitutes are suitable for children

In pediatric practice, Ascoril is used exclusively as prescribed by a doctor, since in rare cases, paradoxical bronchospasm may develop as a side effect of the syrup.

The drug is prescribed to a younger group of patients with complicated bronchopulmonary diseases.

For a productive (wet) cough, the pediatrician, as a cheaper analogue of Ascoril for children, can prescribe “Ambrobene” (148 rubles) in the form of syrup, if the child does not have a history of allergic reactions, otherwise a solution for preparing a suspension is recommended.

In addition, the Russian "Ambroxol" (120 rubles), the Greek "Lazolvan" (210 rubles), the German "Prospan" (417 rubles), and the French "Fluditek" (378 rubles) are often prescribed. These drugs stimulate the thinning of mucus and facilitate its removal.

For dry, unproductive cough, medications that inhibit the cough center in the brain are indicated.

These include prescription syrup "Bronholitin" (121 rubles) as well as over-the-counter ones - "Stoptussin" (161 rubles) "Sinekod" (251 rubles)

To eliminate the spasmodic cough characteristic of whooping cough, Erespal is recommended (250 rubles).

Of the structural substitutes, the syrups used are “Joset” and “Kashnol” (170 and 185 rubles, respectively).

Sinekod

The active ingredient is butamirate . Available in the form of syrup, drops, dragees. The drug has an antitussive effect. Good for dry cough. Makes breathing easier and has a positive effect on spirometric indicators.

After administration, the active substance is quickly absorbed from the gastrointestinal tract. Reaches maximum levels 1.5 hours after administration . Does not accumulate in the body. Excreted through the urinary system.

Indications for use are:

1. Dry cough.
2. Cough caused by smoking.
3. Whooping cough.
4. Bronchitis.
5. Tracheitis.

Contraindications are:

• Allergic reaction to the components of the product.
• First trimester of pregnancy.
• Pulmonary hemorrhage.
• Children under 3 years of age (syrup).
• Children up to 2 months (drops).
• Children under 6 years of age (dragées).

Ascoril or Lazolvan - which is better?

Lazolvan is a cheap analogue of ascoril, which has a different composition from the original product. Its main component is ambroxol hydrochloride, due to which the drug is prescribed as an expectorant and mucolytic agent.

The medicine also has a large number of release forms: syrup, solution for inhalation, lozenges, tablets, capsules, aimed at different age groups of patients. Ascoril is available only in the form of syrup and tablets.

Lazolvan is better suited for the treatment of bronchopulmonary diseases accompanied by cough with an uncomplicated course. Ascoril, unlike its analogue, thanks to its combined composition, is effectively used in the treatment of severe forms of such pathologies.

However, it also has a wider list of possible side effects and contraindications.

If necessary, simultaneous administration of Ascoril and Lazolvan is allowed for a faster onset of the therapeutic effect, but only as prescribed by the attending physician.

Which drug to choose

A table will help you compare Ascoril and Fluditec, which describes the main properties of the medications. A side-by-side comparison shows which drug is more suitable for the treatment of an individual patient.

Askoril or Erespal

Erespal - similar in effectiveness to the original Ascoril. However, unlike it, it is a single drug containing fenspiride hydrochloride.

In this regard, erespal has significantly fewer contraindications for use and side effects occur less frequently, and it is much easier to tolerate by children.

The mechanism of action of the drugs is different. Thus, erespal exhibits an anti-inflammatory effect, prevents the formation of viscous secretions and blocks H1-histamine receptors, relaxing the smooth muscle tissue of the bronchi.

Ascoril stimulates the discharge of sputum. In this regard, it is more appropriate to prescribe Erespal for a prolonged cough with the formation of viscous sputum against the background of elevated body temperature, and Ascoril for a feeling of suffocation after coughing attacks.

Advantages of erespal:

• cheaper than the original;
• fewer contraindications and side effects;
• additional anti-inflammatory effect;
• more pleasant syrup taste.

Flaws:

• less effective for paroxysmal cough;
• course of treatment for at least 10 days (Ascoril, as a rule, is recommended to be taken for 5-7 days).

Conclusion

Thus, both drugs are effective for coughs and it is impossible to say which one is better. Stoptussin is recommended to be used to eliminate dry cough, and Lazolvan to improve sputum discharge. Both medications are well suited for children and pregnant women in the 2nd-3rd trimester. They have a minimal number of contraindications and side effects. It is not worth using the remedies at the same time, as this will not improve the situation, but rather the opposite. If a cough occurs, it is recommended to consult a doctor , since only he will be able to determine the type of cough and prescribe the most effective drug.

Medicine and healthComment

Ascoril or Fluditec

Fluditec is the most similar substitute for ascoril, which has a different composition. The main component of the syrup is carbocisteine, which activates sialic transferase, which determines the complex effect of the drug:

• dilution of viscous sputum;
• an increase in the number of sialomucins, which inhibits the reproduction of pathogenic viruses;
• improving the structure and restoration of the mucous membranes of the respiratory organs;
• a decrease in the number of epithelial goblet cells, due to which secretion production is suppressed.

Just like Ascoril, Fluditec is not prescribed at the early stage of bronchitis or ARVI.

The drug is indicated for pneumonia, cystic fibrosis, bronchiectasis, that is, for a productive cough with heavy sputum discharge.

Fluditec additionally dilutes the contents of the paranasal sinuses, so it is prescribed in the complex treatment of sinusitis and sinusitis.

The advantage of Fluditec is also a smaller list of side effects and contraindications. The syrup can be taken for a long time, as prescribed in the instructions: for chronic bronchitis and bronchial asthma, up to 30 days.

Ascoril accumulates when taken for a long time and can provoke the development of dizziness, nausea, and vomiting.

The course of treatment should not exceed 7 days, so the syrup is prescribed to relieve symptoms caused by the formation and stagnation of a viscous secretion.

Due to the menthol content, ascoril exhibits calming, antispasmodic, and antiseptic activity. It should be taken in case of acute illness.

Ascoril or Ambrobene

The main component of ambrobene is ambroxol hydrochloride. Since the composition of the drugs is completely different, such a replacement is possible only on the recommendation of the attending physician.

Also, thanks to the combination of medicinal substances, the original medicine has a much wider range of indications than Ambrobene.

When using Ascoril, bronchodilator spasms are suppressed, especially at night. In addition, the capacity of the lungs increases, making breathing easier and the removal of viscous secretions.

Ambrobene stimulates the production of serous cells, which increases the amount of sputum. It becomes less viscous and comes off easier.

The advantages of ambrobene are lower cost, fewer contraindications and rare development of side effects.

Disadvantages include the lack of bronchodilator action, a narrower list of indications and a weak therapeutic effect.

Comparison of the effectiveness of Fluditec and Codelac bronchus

Codelac bronchi is more effective than Fluditec - this means that the ability of the drug substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Codelac bronchi is more pronounced, then with Fluditec it is impossible to achieve this effect even in large doses.

Also, the speed of therapy is an indicator of the speed of the therapeutic action; Codelac Bronchi and Fluditec are also different, as is bioavailability - the amount of a drug reaching the site of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Ascoril or Joset - which is better?

Joset is an inexpensive structural analogue of ascoril. The main components of the syrups are identical, as are their dosages, the only difference is in the auxiliary components.

The list of indications, possible side effects, and established contraindications is also similar.

Like the original Ascoril, Joset is used in pediatric practice from the age of 2, strictly under the supervision of a doctor. The duration of therapy is determined by the established diagnosis.

However, unlike askoril, a similar joset is produced only in the form of a 100 ml syrup. That is, for an adult patient, one bottle for a course of treatment is not enough, so therapy can cost even more than the cost of Ascoril.

Analogues of the drug

The drug "Sinekod" has several synonyms, that is, products with the same composition, only from a different manufacturer. These are the drugs “Omnitus”, “Panatus”, “Codelac Neo”. All of them are available in tablets and syrup.

Unlike narcotic antitussives, Sinekod can be taken for a long time. But in some cases, its analogs are still used, for example, “Codterpin” or “Codelac”. But they have more contraindications and are sold only with a doctor's prescription.

But there are also other cough suppressants that are safer and over-the-counter. If for some reason it is impossible for a patient to take Sinekod, the doctor may prescribe him another drug with a bronchodilator effect. The following have a similar effect:

• "Ascoril".
• "Stoptussin."
• Fluditek.
• "Erespal."
• "Bronholitin."

All of them help reduce the frequency of coughing, relieve inflammation, dilate the bronchi and facilitate the patient’s breathing. Some of them also have an antihistamine effect.

Askoril or Prospan - which is better?

Prospan is a herbal preparation containing dry extract of ivy leaves. It is produced in several forms: syrup, solution, drops, lozenges, soluble tablets.

The drug exhibits mucolytic, secretolytic, antispasmodic activity, as well as a mild bronchodilator effect.

Ascoril, unlike prospan, contains synthetic components, making it more effective. The list of indications for this syrup is much wider than that of a similar prospan.

However, there is a longer list of side effects and contraindications.

In addition, it is recommended for children to take it only under the supervision of a physician.

Benefits of oversleeping:

• herbal composition (extract obtained from ivy leaves);
• a short list of side effects and contraindications;
• used in pediatric practice from 1 year.

Flaws:

• high cost compared to ascoril;
• narrow spectrum of action;
• weak bronchodilator effect;
• practically ineffective for bronchospasms.

Ascoril and Prospan can be taken simultaneously to enhance the therapeutic effect.

When choosing an analogue, it should be remembered that an inadequate replacement may cause a decrease in the expected therapeutic effect or its absence.

Such experiments lead to additional expenses, the development of complications, and chronic disease. Only a correct diagnosis and appropriate treatment is the key to a speedy recovery.

Ambrobene lazolvan doctor mom gerbion sinecode ascoril joset drugs for the treatment of cough in children

Feb 18, 2018Yulia Astafieva

Cough in diseases of the upper respiratory tract

When a person gets a cold, the virus penetrates the mucous membrane of the nose, pharynx, and larynx, begins to multiply there and causes inflammation.

What does the body do?

Trying to free himself from him.

https://www.youtube.com/watch?v=ytcopyrighten-GB

The production of mucus increases, the corresponding receptors are irritated, and what do we see and hear?

Runny nose and cough. And if the larynx is involved in the process, then there is also hoarseness. With laryngitis, the cough is dry, with pharyngitis it can be different.

In children, coughing often occurs because snot flows down the back wall of the throat, irritating its receptors.

Are cough medications needed here? No! Here you need nasal drops and all sorts of different “suckers” for the throat, which we have already talked about.

It's clear?

Go ahead.

It is for diseases of the lower respiratory tract that the great variety of cough medications that are presented in the pharmacy are used.

Before talking about them, a short excursion into the anatomy and physiology of the above.

Normally, the cells of the mucous membrane of the trachea and bronchi secrete a very certain amount of secretion. It contains proteins and enzymes, including immunoglobulin A and lysozyme, which provide local protection against viruses and bacteria.

The mucous membrane of the trachea and bronchi has so-called cilia, thanks to which the mucus constantly moves upward to the oral cavity, and its excess, along with foreign particles and microbes, is removed. We don’t notice any of this, it happens so quickly and naturally.

But with inflammation of the trachea and bronchi, much more mucus is released. In addition, its composition is changing. It becomes thick. Eyelashes can no longer cope with either its quantity or its viscosity. The sputum stagnates and clots form. Bacteria begin to multiply in them. The lumen of the bronchus narrows.

Of course, the body is trying to cleanse itself of all this nasty stuff. Excess sputum irritates the receptors of the bronchial mucosa, causing a cough.

This means that the respiratory tract needs to be “helped” in this process: to thin the mucus, improve the functioning of the cilia, and reduce the production of mucus.

But there are situations when a dry cough strikes, which simply exhausts the patient and does not allow him to sleep. Then doctors recommend drugs that suppress cough.

https://www.youtube.com/watch?v=ytcreatorsen-GB

In children, antitussive drugs are used, for example, for whooping cough, since the cause of cough in this case is irritation of the cough center, which is located in the medulla oblongata.