Ascoril or Ambrobene, which is better for a child?

Taking this Indian-made pharmaceutical product is associated with the need to thin sputum, relax the bronchial muscles and increase expectoration. The drug combines active components that enhance the overall treatment result. In the case of tablets, Ascoril contains bromhexine hydrochloride , guaifenesin and salbutamol . If it's syrup, it also includes menthol .

Ascoril has contraindications:

• Allergy to active or excipients.
• Diseases of the heart and blood vessels (among them hypertension).
• Some endocrine diseases, insulin-dependent form of diabetes mellitus).
• Glaucoma.
• Diseases of the digestive system, liver and kidneys.
• During pregnancy and breastfeeding. Resuming feeding is allowed only two days after taking the last dose of the medicine.

Ascoril: pros and cons

Ascoril is a combination drug, as it contains several active ingredients - salbutamol sulfate, bromhexine hydrochloride and guaifenesin. It is produced both in the form of syrup (100 and 200 ml) and in the form of tablets (20 pcs., 50 pcs.). Country of origin: India.

The drug can be used to treat children, but should not be taken during pregnancy or breastfeeding.

• cardiovascular diseases (for example, arrhythmia or coronary insufficiency);
• hyperthyroidism (hyperfunction of the thyroid gland);
• liver damage;
• peptic ulcers;
• individual intolerance to components.

Prescribe with caution to patients with diabetes mellitus, glaucoma, arterial hypertension, and renal impairment.

It is necessary to monitor the simultaneous use of Ascoril with MAO inhibitors, digoxin, diuretics, antitussives (codeine-containing drugs), antibiotics, antidepressants, adrenaline, and corticosteroids.

The use of Ascoril may be accompanied by a significant number of side effects: these include allergic reactions, digestive disorders, headaches, dizziness, heart rhythm disturbances, convulsions and breathing disorders (increased cough).

Cost: from 250 rub. (106 UAH).

Active ingredients of drugs

Ascoril in one tablet contains the main active ingredients:

1. Salbutamol – 2 mg.
2. Bromhexine – 8 mg.
3. Guaifenesin – 100 mg.

The dosage of the main components in 10 ml of syrup is:

1. Salbutamol – 2 mg.
2. Bromhexine – 4 mg.
3. Guaifenesin – 100 mg.

Additional ingredients: talc, corn starch, silicon dioxide and others.

The main active ingredient in Ambrobene is ambroxol. Additional components: magnesium stearate, silicon dioxide, lactose and others.

So, what is more effective than Ascoril or Lazolvan?

Salbutamol sulfate in Ascoril stimulates β-receptors, eliminating bronchospasm; Bromhexine hydrochloride thins mucus, and guaifenazine stimulates its secretion. The combined composition shows high effectiveness in the treatment of bronchopulmonary diseases.

However, it should be remembered that it is for this reason that Ascoril often causes allergic reactions in a child, and is also poorly compatible with other medications. Therefore, its use is not recommended for the treatment of children under one year of age, and children under the age of 6 years are allowed only under the supervision of the attending physician.

The rate of absorption when taken orally is the same (about 30 minutes). Bioavailability differs: 50% for Ascoril and about 80% for Lazolvan.

Mucolytics are most often used for wet coughs, but the manufacturers of Ascoril and Lazolvan claim a therapeutic effect for dry coughs.

Both drugs penetrate the blood-brain barrier. But if Ascoril is not recommended for use during pregnancy or breastfeeding, then the use of Lazolvan is allowed. Despite the absence of proven harm to the child, it is still better to use Lazolvan from the second trimester.

Both Ascoril and Lazolvan can be used for diabetes, but only under medical supervision.

Briefly about the main thing, video about syrups

The compatibility of Ascoril with other drugs is quite low: it is contraindicated in patients with depression (using MAO inhibitors), acute heart failure (associated with taking digoxin and diuretics) or with various types of autoimmune disorders (for which corticosteroids are prescribed).

Lazolvan shows great indifference to drugs from other groups. It is also known that this drug enhances the effects of antibiotics. Therefore, their dosage must be reduced (especially for a child or an elderly person).

Important! Do not self-medicate: only a doctor can recommend the correct dosage of drugs and their combination.

The effect on driving ability has not been studied for either of the two drugs. Therefore, preference should be given to products with known effects.

Ascoril and Ambrobene

Cough is a natural reaction to irritation of the mucous membrane due to inflammation, allergies or mechanical stress.
Therefore, the methods of getting rid of it may be different. The cough can be dry or wet. Dry - unproductive, does not help in the separation of sputum. It needs to either be calmed down or made productive. With a wet cough, phlegm is removed from the bronchi.

To help patients who suffer from a cough reflex, the drugs Ascoril and Ambrobene come to the rescue. What is the difference between cough tablets and in what situations can they be used? You should find out from your doctor.

Description of Askoril

Ascoril is a drug with an expectorant and sputum-thinning effect. Prescribed to relieve cough with difficulty clearing mucus. The base contains salbutamol, bromhexine and guaifenesin. Available in the form of syrup and tablets. Manufacturer: Glenmark Pharmaceuticals Ltd., India.

Features of the action of different components in the composition:

salbutamol - eliminates spasm, relaxing the fibers of the bronchi, stimulates receptors, causing dilation of the arteries, improves the patency of the respiratory system;

Bromhexine – provides mucus release;

guaifenesin - reduces the viscosity of mucus, thinning it;

menthol – additionally contained in the syrup, has an antiseptic effect.

The remedy is used for acute and chronic diseases of the respiratory system, when it is necessary to remove difficult to separate sputum. Prescribed in complex treatment.

Research and effectiveness

Using the drug Ascoril, you can shorten the treatment period and obtain several therapeutic effects at the same time. It affects all parts of the pathological process of bronchopulmonary diseases. Ascoril can be prescribed independently, which reduces the treatment load and the cost of the course of therapy. No serious side effects were observed from its use.

Ascoril is effective in the treatment of ARVI, bronchitis, pneumonia, COPD, asthma. During therapy, patients experience improvement in bronchial patency. The product in the form of a syrup containing menthol helps relieve spasms and stimulates bronchial secretion.

Source: Fedoseev G.B. "Clinical aspects of the use of Ascoril in a pulmonology clinic." New St. Petersburg Medical Gazette. 2002.

Contraindications

Ascoril is not prescribed for hypersensitivity to the active ingredients.

There are other contraindications for use:

some diseases of the cardiovascular system - heart rhythm disturbances, aortic stenosis, hypertension, myocarditis;

endocrine pathologies - increased activity of the thyroid gland, decompensated diabetes;

stable increase in intraocular pressure;

gastrointestinal diseases - ulcers during exacerbation, liver failure, bleeding;

severe failure of kidney function.

Ascoril is used with caution for heart disease, as there is a risk of collapse. For gastric ulcers, the drug can be used only in the remission phase.

During pregnancy, treatment with Ascoril is not recommended. During lactation, you need to stop breastfeeding and resume it only 2 days after the end of treatment.

Side effects

When treated with Ascoril, disorders of various organs and systems may be observed:

digestion - dyspepsia, nausea, bloating, exacerbation of ulcers;

heart and blood vessels - tachycardia, palpitations, drop in blood pressure;

nervous system – insomnia, tremor, headache, convulsions, excitability;

allergic manifestations - itching, redness of the skin, runny nose, shortness of breath.

Severe allergic manifestations may also occur. This is Quincke's edema, anaphylactic shock, bronchospasm. Often the urine turns pink.

Dosage

Tablets and syrup are best taken after meals. The drug is not prescribed for up to a year. For adults, tablets are indicated 1 to 3 times, from 6 years - ½ tablet 2 times. Until 6 years of age, only syrup is used to avoid overdose.

The syrup is indicated for adults: 10 ml 3 times, up to 6 years – 5 ml 3 times, from 6 to 12 years – 5-10 ml 3 times. It is not recommended to take the medicine with dairy products, as this reduces the effectiveness of the drug. The standard course of use of Ascoril is 5-7 days.

Who is it suitable for?

Ascoril is prescribed in monotherapy or in combination with other drugs for the treatment of bronchopulmonary diseases, which are accompanied by difficult sputum discharge.

Indications for the use of tablets and syrup:

whooping cough, tuberculosis, pneumoconiosis;

emphysema, obstructive bronchitis;

cystic fibrosis or cystic fibrosis.

Ascoril is recommended to be taken for occupational diseases when dust inhalation occurs.

Contraindications and side effects

Unfortunately, both drugs have a list of contraindications and features for use. They differ in quantity and “quality,” which becomes the fundamental principle when prescribing.

Lazolvan is contraindicated in the following cases:

1. Individual intolerance to any of the components of the drug.
2. First trimester of pregnancy.
3. Breastfeeding period.
4. Children under 6 years of age for any product except syrup and solution for injection.

Purely as prescribed by a doctor and with extreme caution, it is prescribed to pregnant women (in the second half) in the presence of serious pathologies of the kidneys and liver. The specialist evaluates the desired clinical effect and possible complications.

The list of prohibitions for Askoril is much wider, but some points “intersect” with Lazolvan:

• individual intolerance (general indicator);
• problems with the cardiovascular system - rhythm disturbances, myocardial pathologies;
• hypertension 2 and 3 degrees;
• eye pathologies (in particular glaucoma);
• erosive and ulcerative diseases of the gastrointestinal tract;
• serious problems with the kidneys and liver (common with the previous drug, the only difference being that Ascoril is completely contraindicated, and Lazolvan is partially contraindicated);
• hormonal imbalances (in adolescents with significant disruptions, with endocrine pathologies, in women with pathological menopause);
• diabetes mellitus – syrup is not allowed at all, tablets are allowed only after consultation with a doctor;
• Absolutely no for expectant and nursing mothers;
• children under one year of age - syrup, up to 6 years - tablets.

There are significantly more contraindications, but in terms of side effects, Lazolvan takes the lead.

When taking it, the following are possible:

1. Changes in taste, sensitivity of the oral mucosa, dryness.
2. Pain in the epigastrium, accompanied by nausea, sometimes to the point of vomiting.
3. Allergic manifestations in the form of redness of the skin with itching, rash like urticaria.
4. In rare cases, anaphylactic shock and Quincke's edema may develop.

While taking Ascoril, mild tremors of the limbs (very rare), discomfort in the projection of the stomach with mild nausea, and a rash on the skin are noted. In case of overdose, bronchospasm and tachycardia are possible.

Description of Lazolvan

The main difference between Lazolvan and Askoril is the composition. It contains only one active ingredient - ambroxol hydrochloride. This is a mucolytic agent that thins and removes mucus, thereby improving breathing. Available in the form of tablets and solution for inhalation. Manufacturer: Boehringer Ingelheim, Germany/Italy.

Research shows that ambroxol increases secretion in the respiratory tract, thins viscous mucus, facilitating its elimination. Long-term use of the drug reduces the number of relapses in obstructive disease. Also reduces the course of antibiotic treatment.

Which drug is better

Ascoril is best taken in the complex treatment of severe diseases of the respiratory system: emphysema, tuberculosis, catracheobronchitis, pneumoconiosis. Not prescribed for infants and pregnant women. Lazolvan works well in the treatment of cough with difficult sputum discharge. It is prescribed for respiratory failure of various origins.

Lazolvan is cheaper, but it is ineffective for some diseases. Before using the medicine, you should definitely consult your doctor to choose the most effective and safe cough medicine.

source

Causes/treatments/types of cough, and which doctor should I contact?

When choosing between lozalvan or codelac broncho, you first need to find out the causes and type of cough.

It is divided into :

1. Dry cough. With this type, there is no phlegm, it is difficult and dry to breathe. There is a constant feeling of dryness in the mouth, while the throat burns and prevents drinking normally. Bronchial mucus, which washes the membrane, is not produced.
2. Moist cough. It is considered a less unpleasant form. Sputum is released, and bronchial mucus begins to be coughed up. A wet cough is the first step to recovery after severe respiratory illness.

Causes:

• Colds and viral diseases due to hypothermia.
• Severe respiratory tract diseases due to caught infections.
• Occurs after long walks in inappropriate clothing during the winter season.

Who should I contact?

• An ENT specialist or therapist will help you cope and prescribe the necessary, safe medications.

Do not self-medicate. Do not delay the treatment process, because a normal cough can develop into a serious illness. Remember this and do not risk your health.

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Ascoril or Lazolvan - which is better?

The solution to the problem of relieving coughs during colds and bronchitis is relevant for adults and children: the sooner sputum containing a significant amount of pathogens leaves the respiratory tract, the faster recovery will occur. Ascoril or Lazolvan will help cope with cough by facilitating the release of phlegm from the lungs by diluting it.

What is the difference?

First of all, the drugs differ in completely different composition, while the purpose of administration remains the same: to relieve cough by improving sputum discharge.

The composition of these cough remedies varies both qualitatively and quantitatively:

• Ascoril contains 3 active ingredients aimed at improving sputum discharge: salbutamol, bromhexine, guaifenzine
  . Available in India in 2 forms: tablets and syrup. The content of active ingredients in both syrup and tablets is the same.
• Lazolvan is represented by one active component - ambroxol
  . Initially, this is a German drug, but depending on the form of release, it is produced in factories in different European countries. It has a more extensive list of produced forms: in our pharmacies it is available in tablets, children’s syrup, long-acting capsules (L. “Max”), nasal spray, solution for nebulizer and oral administration. Indicated for bronchitis, pneumonia, COPD and asthma, bronchiectasis.

Features of application

Difference in dosing regimen (regardless of food intake)

Ambroxol can only act if you consume large amounts of liquid. The substance breaks the molecular bonds in mucopolysaccharides of sputum, thereby liquefying it, but this reaction occurs with a sufficient amount of water. Lazolvan in any form of release is washed down with plenty of liquid: juice, mineral and drinking water, compote.

German syrup with ambroxol does not contain sucrose (unlike its Indian counterpart) and lactose, so it can be used in children with diabetes and lactase deficiency.

How to use

The drug Ascoril is prescribed orally, regardless of food intake. Tablets are prescribed to adults and children over 12 years of age, and syrup is prescribed to children under 6 years of age.

Most often, Ambrobene is prescribed in tablet form. The dosage of the medication directly depends on the age category. The drug must be taken at the same time throughout the course of treatment. The dose of the drug is calculated by a medical specialist. The course of therapy usually lasts up to 5 days. Children under 24 months should take the drug under the supervision of a specialist.

Is it possible to combine?

Adult patients can use Ascoril and Lazolvan together, since they belong to the same group and do not contradict each other’s actions. When treating a cough with two remedies, a significant increase in the amount of sputum should be expected. The drugs should not be taken with antitussives.

What's best for children?

Treatment of cough in young children requires special attention. To the question whether it is possible to give Lazolvan and Ascoril to a child at the same time, the answer is negative. The child's respiratory tract is characterized by an underdeveloped cough reflex. If you give both drugs at once, the amount of sputum will increase significantly, which is fraught with dangerous consequences.

Ambroxol-based products are contraindicated for children under 6 years of age. During this age period, you can treat with Ascoril. Cough syrup is used in young children.

Lazolvan or Ascoril can be given to a child over 6 years old in syrup and tablet form, following the recommended dosages (see table above). If a young patient has a tendency to obstruction, as well as a history of asthmatic attacks, an Indian remedy is more suitable.

What to choose?

The list of expectorants presented is wide, so it can be difficult to settle on one remedy. Decide whether Ascoril or Lazolvan is better based on the nature of the cough.

If you have difficulty breathing, Lazolvan is more suitable. In one independent study, ambroxol showed a 25% improvement in airflow and reduced forced expiration compared to bromhexine. For adults, extended-release capsules (“Max”) would be a more convenient medicine. If you are prone to narrowing of the bronchi, have a scanty amount of sputum that does not cough up, you can opt for Ascoril.

For infectious diseases of the respiratory tract and treatment with antibiotics from the group of amoxicillins and cephalosporins, it is advisable to use the drug with ambroxol, as it increases the concentration of the antibiotic in the bronchial secretions.

There is no difference in the cost of the syrups, the tablets also do not differ significantly in cost, however, a large package of tablets of 50 pieces of the Indian drug will cost 2 times more.

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